Where will new antibiotics come from?

Lecture 1

Novel Inhibitors of Bacterial Cytokinesis Identified by a Cell-based Antibiotic Screening Assay

Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing

Animation showing the assembly process for polyketide synthase-derived natural products

Lecture 2

Antibacterial drug discovery through bacteriophage genomics

Regulatory issues for phage-based clinical products

A bacteriolytic agent that detects and kills Bacillus anthracis

Stalin’s forgotten cure

Lecture 3

Concurrent Growth Rate and Transcript Analyses Reveal Essential Gene Stringency in Escherichia coli

Lecture 4

A genome-wide strategy for the identification of essential genes in Staphylococcus aureus

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

Paired termini stabilize antisense RNAs and enhance conditional gene silencing in Escherichia coli

Regulatory RNAs in Bacteria

Lecture 5

Discovery of a new peptide natural product by Streptomyces coelicolor genome mining

A genomics-guided approach to discovering and expressing cryptic biosynthetic gene clusters

Recent developments towards the heterologous expression of natural product biosynthetic pathways

Enzymatic total synthesis of enterocin polyketides

Epigenetic remodeling of the fungal secondary metabolome

Lecture 6

Integrated antifungal drug discovery in C. albicans

An antisense-based functional genomics approach for the identification of genes critical for the growth of C. albicans

identification of antifungal codrugs through natural product screening

Discovery and characterization of ß-1,6-glucan inhibitors

Current status and future of antifungal therapy for systemic mycoses

Lecture 7

Discovering the Mechanism of Action of Novel Antibacterial Agents through Transcriptional Profiling of Conditional Mutants

Genome-Wide Fitness Test and Mechanism-of-Action Studies of Inhibitory Compounds in Candida albicans

Using microarray gene signatures to elucidate mechanisms of antibiotic action and resistance

Chemical microarray: a new tool for drug screening and discovery

Lecture 8

An Inhibitor of FtsZ with Potent and Selective Anti-Staphylococcal Activity

N-Alkyl Urea Hydroxamic Acids as a New Class of Peptide Deformylase Inhibitors with Antibacterial Activity

Antibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase Inhibitor

Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ

Chris Lipinski discusses life and chemistry after the Rule of Five

Boron in drug-discovery

Lecture 9

Dual acting hybrid antibiotics a promising strategy to combat bacterial resistance

The Mycobacterium tuberculosis Drugome and Its Polypharmacological Implications

How many modes of action should an antibiotic have?

Lecture 10

Combining two cells in one

Production of artemisinin by genetically modified microbes

Complete Chemical Synthesis of a Mycoplasma genitalium genome

Minimal Mycoplasma genome

Engineering Escherichia coli to see light

Engineering a mevalonate pathway in Escherichia coli for production of terpenoid

synthetic biology and drug discovery

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