READING

Miscellaneous Stuff

Polyketide and Non-Ribosomal Peptide Synthesis

Many of the interesting antimicrobial compounds made by bacteria are derived from polyketides or amino acids. For this course a good understanding of how they are made is required. Christopher Walsh’s book: ANTIBIOTICS, actions, origins, resistance is great place to start (chapters 12 and 13) and is available in the library. Non-Ribosomal Peptide Sythetases in more detail in the material below. A previous student produced a learning resource for polyketide synthesis, and you can download it (N.B. it is a Flash swf file, you’ll need to set your browser to enable Flash) Polyketide Biosynthesis.

Lecture 2 - Phage, pyocins and PlyG

Lecture 5 - Non-Ribosomal Peptide Synthetases

Lecture 8 - Getting antibiotics into Gram-negatives

Lecture 6 - Fungal cell-wall inhibitor assay

Lecture 5 - TAR cloning biosynthetic gene clusters