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Amiloride

2010-11-16T15:55:07Z

090161371:

Amiloride is a drug used to treat [[Hypertension|hypertension]] ( high [[Blood pressure|blood pressure]] ). It is a "potassium-sparing" [[Diuretic|diuretic that]] acts by blocking [[Enac|Enac]] (epithelial sodium channel) inhibiting the reabsorption of [[Sodium|sodium]] by the distal convoluted tubules and collecting ducts within the [[Kidneys|kidneys]]. By doing this it promotes the excretion of [[Sodium|sodium]] and [[Water|water]] from the bloodstream, thereby reducing blood pressure.[1] 

Its chemical structure is detailed below:

  [http://www.google.co.uk/imgres?imgurl=http://www.medicinescomplete.com/mc/martindale/2009/images/CLK0081C001.gif&imgrefurl=http://www.medicinescomplete.com/mc/martindale/2009/2304-d.htm&usg=__L8bOh4b1SkQBIAGIu07PBPtG1HA=&h=76&w=163&sz=4&hl=en&start=8&zoom=0&itbs=1&tbnid=_h97Mte0OTxqpM:&tbnh=46&tbnw=98&prev=/images%3Fq%3Damiloride%2Bstructure%26hl%3Den%26gbv%3D2%26tbs%3Disch:1 [[Image:Amiloride structure.gif|This details the chemical structure of amiloride]]] [2]

Adverse side effects of the drug (amiloride hydrochloride) can become as severe as [[Hyperkalemia|hyperkalemia]], which can lead to cardiac arythmias. Should be given with caution to patients with impaired renal function, [[Diabetes|diabetes mellitus]] or the elderly. Amiloride's inhibition of Na+ in the [[Distal tubule|distal tubule also]] results in reduced electrical potenial across the membrane which in turn leads to inhibition of passive K+ secretion.[3] 

=== References: ===

1. [http://www.pharmgkb.org/views/index.jsp?objId=PA448368#tabview=tab1 http://www.pharmgkb.org/views/index.jsp?objId=PA448368#tabview=tab1]

2. http://www.medicinescomplete.com/mc/martindale/2009/images/CLK0081C001.gif

3. [http://www.inchem.org/documents/pims/pharm/pim026.htm http://www.inchem.org/documents/pims/pharm/pim026.htm]

Amiloride

2010-11-16T15:53:21Z

090161371:

Amiloride is a drug used to treat [[Hypertension|hypertension]] ( high [[Blood pressure|blood pressure]] ). It is a "potassium-sparing" [[Diuretic|diuretic that]] acts by blocking [[Enac|Enac]] (epithelial sodium channel) inhibiting the reabsorption of [[Sodium|sodium]] by the distal convoluted tubules and collecting ducts within the [[Kidneys|kidneys]][1]. By doing this it promotes the excretion of [[Sodium|sodium]] and [[Water|water]] from the bloodstream, thereby reducing blood pressure. 

Its chemical structure is detailed below:

  [http://www.google.co.uk/imgres?imgurl=http://www.medicinescomplete.com/mc/martindale/2009/images/CLK0081C001.gif&imgrefurl=http://www.medicinescomplete.com/mc/martindale/2009/2304-d.htm&usg=__L8bOh4b1SkQBIAGIu07PBPtG1HA=&h=76&w=163&sz=4&hl=en&start=8&zoom=0&itbs=1&tbnid=_h97Mte0OTxqpM:&tbnh=46&tbnw=98&prev=/images%3Fq%3Damiloride%2Bstructure%26hl%3Den%26gbv%3D2%26tbs%3Disch:1 [[Image:Amiloride structure.gif|This details the chemical structure of amiloride]]]

Adverse side effects of the drug (amiloride hydrochloride) can become as severe as [[Hyperkalemia|hyperkalemia]], which can lead to cardiac arythmias. Should be given with caution to patients with impaired renal function, [[Diabetes|diabetes mellitus]] or the elderly. Amiloride's inhibition of Na+ in the [[Distal tubule|distal tubule also]] results in reduced electrical potenial across the membrane which in turn leads to inhibition of passive K+ secretion. 

=== References: ===

1. [http://www.pharmgkb.org/views/index.jsp?objId=PA448368#tabview=tab1 http://www.pharmgkb.org/views/index.jsp?objId=PA448368#tabview=tab1]

2. http://www.medicinescomplete.com/mc/martindale/2009/images/CLK0081C001.gif

3. [http://www.inchem.org/documents/pims/pharm/pim026.htm http://www.inchem.org/documents/pims/pharm/pim026.htm]

Amiloride

2010-11-16T15:51:25Z

090161371:

Amiloride is a drug used to treat [[Hypertension|hypertension]] ( high [[Blood pressure|blood pressure]] ). It is a "potassium-sparing" [[Diuretic|diuretic that]] acts by blocking [[Enac|Enac]] (epithelial sodium channel) inhibiting the reabsorption of [[Sodium|sodium]] by the distal convoluted tubules and collecting ducts within the [[Kidneys|kidneys]]. By doing this it promotes the excretion of [[Sodium|sodium]] and [[Water|water]] from the bloodstream, thereby reducing blood pressure. 

Its chemical structure is detailed below:

  [http://www.google.co.uk/imgres?imgurl=http://www.medicinescomplete.com/mc/martindale/2009/images/CLK0081C001.gif&imgrefurl=http://www.medicinescomplete.com/mc/martindale/2009/2304-d.htm&usg=__L8bOh4b1SkQBIAGIu07PBPtG1HA=&h=76&w=163&sz=4&hl=en&start=8&zoom=0&itbs=1&tbnid=_h97Mte0OTxqpM:&tbnh=46&tbnw=98&prev=/images%3Fq%3Damiloride%2Bstructure%26hl%3Den%26gbv%3D2%26tbs%3Disch:1 [[Image:Amiloride structure.gif|This details the chemical structure of amiloride]]]

Adverse side effects of the drug (amiloride hydrochloride) can become as severe as [[hyperkalemia|hyperkalemia]], which can lead to cardiac arythmias. Should be given with caution to patients with impaired renal function, [[Diabetes|diabetes ]]mellitus or the elderly. Amiloride's inhibition of Na+ in the [[distal tubule|distal tubule ]]also results in reduced electrical potenial across the membrane which in turn leads to inhibition of passive K+ secretion. 

=== References: ===

1. [http://www.pharmgkb.org/views/index.jsp?objId=PA448368#tabview=tab1 http://www.pharmgkb.org/views/index.jsp?objId=PA448368#tabview=tab1]

2. http://www.medicinescomplete.com/mc/martindale/2009/images/CLK0081C001.gif

3. [http://www.inchem.org/documents/pims/pharm/pim026.htm http://www.inchem.org/documents/pims/pharm/pim026.htm]

Amiloride

2010-11-16T15:50:56Z

090161371:

Amiloride is a drug used to treat [[Hypertension|hypertension]] ( high [[Blood pressure|blood pressure]] ). It is a "potassium-sparing" [[Diuretic|diuretic that]] acts by blocking [[Enac|Enac]] (epithelial sodium channel) inhibiting the reabsorption of [[Sodium|sodium]] by the distal convoluted tubules and collecting ducts within the [[Kidneys|kidneys]]. By doing this it promotes the excretion of [[Sodium|sodium]] and [[Water|water]] from the bloodstream, thereby reducing blood pressure. 

Its chemical structure is detailed below:

  [http://www.google.co.uk/imgres?imgurl=http://www.medicinescomplete.com/mc/martindale/2009/images/CLK0081C001.gif&imgrefurl=http://www.medicinescomplete.com/mc/martindale/2009/2304-d.htm&usg=__L8bOh4b1SkQBIAGIu07PBPtG1HA=&h=76&w=163&sz=4&hl=en&start=8&zoom=0&itbs=1&tbnid=_h97Mte0OTxqpM:&tbnh=46&tbnw=98&prev=/images%3Fq%3Damiloride%2Bstructure%26hl%3Den%26gbv%3D2%26tbs%3Disch:1 [[Image:Amiloride structure.gif|This details the chemical structure of amiloride]]]

Adverse side effects of the drug (amiloride hydrochloride) can become as severe as [[hyperkalemia|hyperkalemia]], which can lead to cardiac arythmias. Should be given with caution to patients with impaired renal function, [[Diabetes|diabetes ]]mellitus or the elderly. Amiloride's inhibition of Na+ in the [[distal tubule|distal tubule ]]also results in reduced electrical potenial across the membrane which in turn leads to inhibition of passive K+ secretion. 

=== References: ===

[http://www.pharmgkb.org/views/index.jsp?objId=PA448368#tabview=tab1 http://www.pharmgkb.org/views/index.jsp?objId=PA448368#tabview=tab1]

http://www.medicinescomplete.com/mc/martindale/2009/images/CLK0081C001.gif

[http://www.inchem.org/documents/pims/pharm/pim026.htm http://www.inchem.org/documents/pims/pharm/pim026.htm]

Amiloride

2010-11-15T15:51:08Z

090161371:

Amiloride

2010-11-15T15:45:44Z

090161371:

Amiloride

2010-11-15T15:41:45Z

090161371:

DNA

2010-11-08T11:37:02Z

090161371:

DNA (deoxyribonucleic acid) is the genetic information found in most organisms. It is arranged into structures called chromosomes. The structure of DNA was identified as being a 'double-helix' by Watson and Crick in 1953.

DNA is composed of 4 bases; [[Adenine|Adenine]] (A), [[Thymine|Thymine]] (T), [[Guanine|Guanine]] (G) and [[Cytosine|Cytosine]] (C). These form complementary bases pairs of AT and GC. Contains a [[phosphates|phosphate]] group connected to a deoxyribose sugar.

DNA

2010-11-08T11:34:32Z

090161371:

DNA

2010-11-08T11:34:18Z

090161371: