The School of Biomedical Sciences Wiki - User contributions [en]

Graft versus Host Disease

2012-10-21T14:23:14Z

110044620:

A complication that may arise following a stem cell or bone marrow transplant which occurs due to the donor cells recognising the hosts bodily cells as foreign and proceeding to attack the recipients bodily cells. In order to limit the chances of GVHD (Graft versus Host Disease) occuring patients will be tested before the transplant to determine how close the match is between the donor and the recipients cells. A closer match between the donor and recipient will mean that GHVD is less likely to occur in the recipient and if it does then the symptoms will be less severe.     The chances of getting GVHD (and the severity of it) vary depending on the relation between the donor and the recipient. In cases where the recipient is also the donor (autologous transplant) there is no chance of the patient getting GVHD. In cases when the donor is the identical twin of the recipient the chances of aquiring GVHD are extremely low. If the donor and the recipient are related then the chance of getting GVHD lies between 30 - 40%. Whereas if the donor and recipient are not related then the chances of GVHD occuring is between 60 - 80%     Usually GVHD will either appear in a patient in one of two forms:

*Acute, with symptoms occuring in the first 3 months after the transplant
*Chronic, with symptoms arising 3 months after the transplant (can last up to a lifetime)

 

  The severity of GVHD largely depends upon how closely matched the donor cells/tissue is to the recipients cells/tissue. The symptoms of GVHD can vary from mild symptoms (such as dryness of the mouth) to much more severe symptoms (recipient bodily organ damage). When testing for GVHD a range of lab and imaging tests are available and a biopsy may also be performed to confirm the diagnosis. In order to prevent the recipeint developing GVHD (or lower the severity) the patient may be placed on immunosuppressant drugs. The patient will continue to take the medication until they are deemed to be no longer at risk of GVHD, however this can be problematic due to the side effects of taking immunosuppressant medication. <ref>http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002286/</ref> 

=== '''References''' <references /> ===

Graft versus Host Disease

2012-10-21T14:21:21Z

110044620: Created page with "= Graft versus Host Disease =     A complication that may arise following a stem cell or bone marrow transplant which occurs due to the donor cells recognising the ho..."

= Graft versus Host Disease =

    A complication that may arise following a stem cell or bone marrow transplant which occurs due to the donor cells recognising the hosts bodily cells as foreign and proceeding to attack the recipients bodily cells. In order to limit the chances of GVHD (Graft versus Host Disease) occuring patients will be tested before the transplant to determine how close the match is between the donor and the recipients cells. A closer match between the donor and recipient will mean that GHVD is less likely to occur in the recipient and if it does then the symptoms will be less severe.     The chances of getting GVHD (and the severity of it) vary depending on the relation between the donor and the recipient. In cases where the recipient is also the donor (autologous transplant) there is no chance of the patient getting GVHD. In cases when the donor is the identical twin of the recipient the chances of aquiring GVHD are extremely low. If the donor and the recipient are related then the chance of getting GVHD lies between 30 - 40%. Whereas if the donor and recipient are not related then the chances of GVHD occuring is between 60 - 80%     Usually GVHD will either appear in a patient in one of two forms:

*Acute, with symptoms occuring in the first 3 months after the transplant
*Chronic, with symptoms arising 3 months after the transplant (can last up to a lifetime)

 

  The severity of GVHD largely depends upon how closely matched the donor cells/tissue is to the recipients cells/tissue. The symptoms of GVHD can vary from mild symptoms (such as dryness of the mouth) to much more severe symptoms (recipient bodily organ damage). When testing for GVHD a range of lab and imaging tests are available and a biopsy may also be performed to confirm the diagnosis. In order to prevent the recipeint developing GVHD (or lower the severity) the patient may be placed on immunosuppressant drugs. The patient will continue to take the medication until they are deemed to be no longer at risk of GVHD, however this can be problematic due to the side effects of taking immunosuppressant medication. <ref>http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002286/</ref> 

=== '''References''' <references /> ===

Arabidopsis thaliana

2011-11-30T21:40:29Z

110044620:

Arabidopsis thaliana (common Thale cress) is a small weed which has been chosen as the primary [[Model organism|model organism]] for studying plant molecular genetics. A. thaliana was chosen as a model organism due to; the large supply of the plants available, fully sequenced [[Genome|genome]] (roughly 140 million nucleotide pairs), able to produce thousands of offspring per plant after 8-10 weeks and being able to generate [[Mutants|mutants]] with the use of mutagenic chemicals (simple genetic manipulation)<ref name="null">Alberts B., Johnson A., Lewis J., Raff M., Roberts K. and Walter P. (2008) Molecular Biology of the cell, 5th edition, New York: Garland Science page 36</ref>

 

 

= References =

  <references />

Arabidopsis thaliana

2011-11-30T21:38:43Z

110044620:

Arabidopsis thaliana (common Thale cress) is a small weed which has been chosen as the primary [[Model organism|model organism]] for studying plant molecular genetics. A. thaliana was chosen as a model organism due to; the large supply of the plants available, fully sequenced [[Genome|genome]] (roughly 140 million nucleotide pairs), able to produce thousands of offspring per plant after 8-10 weeks and being able to generate [[mutants|mutants]] with the use of mutageninc chemicals (simple genetic manipulation)<ref name="null">Alberts B., Johnson A., Lewis J., Raff M., Roberts K. and Walter P. (2008) Molecular Biology of the cell, 5th edition, New York: Garland Science page 36</ref>

 

 

= References =

  <references />

Arabidopsis thaliana

2011-11-30T21:36:27Z

110044620:

Arabidopsis thaliana (common Thale cress) is a small weed which has been chosen as the primary [[Model organism|model organism]] for studying plant molecular genetics. thaliana was chosen as a model organism due to; the large supply of the plants available, fully sequenced [[Genome|genome]] (roughly 140 million nucleotide pairs), able to produce thousands of offspring per plant after 8-10 weeks and allowing the use of mutagenic chemicals in order to produce [[Mutant|mutants]] (easy genetic manipulation).<ref name="null">Alberts B., Johnson A., Lewis J., Raff M., Roberts K. and Walter P. (2008) Molecular Biology of the cell, 5th edition, New York: Garland Science page 36</ref>

 

 

= References =

  <references />

Arabidopsis thaliana

2011-11-30T21:30:47Z

110044620:

Arabidopsis thaliana (common Thale cress) is a small weed which has been chosen as the primary [[Model organism|model organism]] for studying plant molecular genetics.<ref name="null">Alberts B., Johnson A., Lewis J., Raff M., Roberts K. and Walter P. (2008) Molecular Biology of the cell, 5th edition, New York: Garland Science page 36</ref>

The features which make the plant a suitable model organism include;

#Large supply of the plants available
#Fully sequenced [[Genome|genome]] (roughly 140 million nucleotide pairs)
#Production of thousands of offspring per plant after 8-10 weeks <ref>Alberts B., Johnson A., Lewis J., Raff M., Roberts K. and Walter P. (2008) Molecular Biology of the cell, 5th edition, New York: Garland Science page 36</ref>
#Use of mutagenic chemicals to produce [[Mutant|mutants]] (easy genetic manipulation)

 

 

= References =

  <references />

Arabidopsis thaliana

2011-11-30T21:29:14Z

110044620:

Arabidopsis thaliana

2011-11-30T21:28:04Z

110044620:

Arabidopsis thaliana (common Thale cress) is a small weed which has been chosen as the primary [[Model organism|model organism]] for studying plant molecular genetics.<ref>Alberts B., Johnson A., Lewis J., Raff M., Roberts K. and Walter P. (2008) Molecular Biology of the cell, 5th edition, New York: Garland Science page 36</ref>

The features which make the plant a suitable model organism include;

#Large supply of the plants available
#Fully sequenced [[Genome|genome]] (roughly 140 million nucleotide pairs)
#Production of thousands of offspring per plant after 8-10 weeks
#Use of mutagenic chemicals to produce [[Mutant|mutants]] (easy genetic manipulation)

 

 

= References =

  <references />

Arabidopsis thaliana

2011-11-30T21:27:29Z

110044620:

Arabidopsis thaliana (common Thale cress) is a small weed which has been chosen as the primary [[Model organism|model organism]] for studying plant molecular genetics.

The features which make the plant a suitable model organism include;

#Large supply of the plants available
#Fully sequenced [[Genome|genome]] (roughly 140 million nucleotide pairs)
#Production of thousands of offspring per plant after 8-10 weeks
#Use of mutagenic chemicals to produce [[Mutant|mutants]] (easy genetic manipulation)

 

 

= References =

 <ref>Alberts B., Johnson A., Lewis J., Raff M., Roberts K. and Walter P. (2008) Molecular Biology of the cell, 5th edition, New York: Garland Science page 36</ref>

Arabidopsis thaliana

2011-11-30T21:27:15Z

110044620:

Arabidopsis thaliana (common Thale cress) is a small weed which has been chosen as the primary [[Model organism|model organism]] for studying plant molecular genetics.

The features which make the plant a suitable model organism include;

#Large supply of the plants available
#Fully sequenced [[Genome|genome]] (roughly 140 million nucleotide pairs)
#Production of thousands of offspring per plant after 8-10 weeks
#Use of mutagenic chemicals to produce [[Mutant|mutants]] (easy genetic manipulation)

 

 

= References =

 <references /><ref>Alberts B., Johnson A., Lewis J., Raff M., Roberts K. and Walter P. (2008) Molecular Biology of the cell, 5th edition, New York: Garland Science page 36</ref>

Arabidopsis thaliana

2011-11-30T21:24:38Z

110044620:

Arabidopsis thaliana (common Thale cress) is a small weed which has been chosen as the primary [[Model_organism|model organism]] for studying plant molecular genetics.

The features which make the plant a suitable model organism include;

#Large supply of the plants available
#Fully sequenced [[Genome|genome]] (roughly 140 million nucleotide pairs)
#Production of thousands of offspring per plant after 8-10 weeks
#Use of mutagenic chemicals to produce [[mutant|mutants]] (easy genetic manipulation)

= References =

<ref>Alberts B., Johnson A., Lewis J., Raff M., Roberts K. and Walter P. (2008) Molecular Biology of the cell, 5th edition, New York: Garland Science</ref>

Arabidopsis thaliana

2011-11-30T21:18:51Z

110044620:

Arabidopsis thaliana (common Thale cress) is a small weed which has been chosen as the primary model organism for studying plant molecular genetics.

The features which make the plant a suitable model organism include;

#Large supply of the plants available
#Fully sequenced genome (roughly 140 million nucleotide pairs)
#Production of thousands of offspring per plant after 8-10 weeks
#Use of mutagenic chemicals to produce mutants (easy genetic manipulation)

Arabidopsis thaliana

2011-11-30T21:11:54Z

110044620: Created page with "Arabidopsis thaliana (common Thale cress) is a small weed which has been chosen by molecular biologists as the primary model organism for studying plant ..."

Arabidopsis thaliana (common Thale cress) is a small weed which has been chosen by molecular biologists as the primary model organism for studying plant molecular genetics.

The features which make the plant a suitable model organism include;

1.) Large supply of the plants available 2.) Fully sequenced genome (roughly 140 million nucleotide pairs) 3.) Production of thousands of offspring per plant after 8-10 weeks 4.) Use of mutagenic chemicals to produce mutants (easy genetic manipulation)