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Calmodulin

2011-11-28T16:36:16Z

110554473:

[[Calcium|Calcium binding]] protein involved in [[Calcium signalling|intracellular calcium signalling.]] <ref>Alberts et al. Molecular Biology of the Cell (5th Ed)</ref>

=== Structure ===

Highly conserved sequence of 152 [[Amino acids|amino acids]] <ref>http://www.ncbi.nlm.nih.gov/protein/CAA36839.1</ref>

There are four [[EFh domains|EFh domains]] which are responsible to bind 4 Ca2+  molecules<ref>http://smart.embl-heidelberg.de/smart/job_status.pl?jobid=939661123169621289746763YwAuDuwGQT</ref>  

The arrangement of the Ca2+ binding sites are brought about by the N- and C- terminal lobes.<ref>http://www.cell-signalling.org/csb/004/csb004.pdf</ref>

Calmodulin are dumbbell shaped protein where long and flexible [[Alpha-helix|alpha helix]] connects two [[Globular domains|globular domains]]. Each domain is assembled from two [[EF-hand|EF-hand]] regions attached to antiparalel [[Beta-sheet|beta-sheet]]. Ca2+ binds to [[Glutamate|glutamate]] and [[Aspartate|aspartate]] residues placed in the loop of EF-hand.<ref>John T.Hancock (2005).Cell signalling. New York:Oxford University press</ref>

=== Function ===

Calmodulin functions as a multi-purpose intracellular receptor,governing many Ca2+  regulated processes. <ref>Alberts et al. Molecular Biology of the Cell (5th Ed).</ref> 

Two or more Ca2+ ions bind to induce a [[Conformational change|conformational change]] and activate calmodulin <ref>Alberts et al. Molecular Biology of the Cell (5th Ed)</ref>. This results in amplifying the affinity of Ca2+ molecule which later affects other signalling components such as Ca2+/calmodulin-dependent protein kinases (CaMKs), myosin light chain kinase (MLCK), phosphorylase kinase, neuromodulin and so on. <ref>http://www.cell-signalling.org/csb/004/csb004.pdf</ref>

=== References ===

<references />

Calmodulin

2011-11-28T16:23:10Z

110554473:

Calmodulin

2011-11-28T16:22:47Z

110554473:

[[Calcium|Calcium binding]] protein involved in [[Calcium signalling|intracellular calcium signalling.]] <ref>Alberts et al. Molecular Biology of the Cell (5th Ed)</ref>

=== Structure ===

Highly conserved sequence of 152 [[Amino acids|amino acids]] <ref>http://www.ncbi.nlm.nih.gov/protein/CAA36839.1</ref>

There are four [[EFh domains|EFh domains]] which are responsible to bind 4 Ca2+  molecules<ref>http://smart.embl-heidelberg.de/smart/job_status.pl?jobid=939661123169621289746763YwAuDuwGQT</ref>  

The arrangement of the Ca2+ binding sites are brought about by the N- and C- terminal lobes.<ref>http://www.cell-signalling.org/csb/004/csb004.pdf</ref>

Calmodulin are dumbbell shaped protein where long and flexible [[Alpha-helix|alpha helix]] connects two [[Globular domains|globular domains]]. Each domain is assembled from two [[EF-hand|EF-hand]] regions attached to antiparalel [[Beta-sheet|beta-sheet]]. Ca2+ binds to [[Glutamate|glutamate]] and [[Aspartate|aspartate]] residues placed in the loop of EF-hand.<ref>John T.Hancock (2005).Cell signalling. New York:Oxford University press</ref>

=== Function ===

Calmodulin functions as a multi-purpose intracellular receptor,governing many Ca2+  regulated processes. <ref>Alberts et al. Molecular Biology of the Cell (5th Ed).</ref> 

Two or more Ca2+ ions bind to induce a [[Conformational change|conformational change]] and activate calmodulin <ref>Alberts et al. Molecular Biology of the Cell (5th Ed)</ref>.

=== References ===

<references />