The School of Biomedical Sciences Wiki - User contributions [en]

HDAC

2018-10-18T13:36:15Z

170094085: Created page with " HDACs are a group of [https://teaching.ncl.ac.uk/bms/wiki/index.php/Enzyme enzymes ]which serve to [https://teaching.ncl.ac.uk/bms/wiki/index.php/Catalysis catalyse] the de..."

 HDACs are a group of [https://teaching.ncl.ac.uk/bms/wiki/index.php/Enzyme enzymes ]which serve to [https://teaching.ncl.ac.uk/bms/wiki/index.php/Catalysis catalyse] the deacetylation of [https://teaching.ncl.ac.uk/bms/wiki/index.php/Lysine lysine] residues primarily in [https://teaching.ncl.ac.uk/bms/wiki/index.php/Histones histone] proteins. Histone deacetylases serve to reverse the action of [https://teaching.ncl.ac.uk/bms/wiki/index.php/Histone_Acetyl_Transferases histone acetylases] (HATs). As [https://teaching.ncl.ac.uk/bms/wiki/index.php/Acetylation acetylation] serves to increase the expression of [https://teaching.ncl.ac.uk/bms/wiki/index.php/Gene genes] by recruitment of bromodomains, deacetylation serves to decrease expression, therefore increasing repression<ref>Seto E, Yoshida M. Erasers of Histone Acetylation: The Histone Deacetylase Enzymes. Cold Spring Harbor Perspectives in Biology. 2014;6(4):a018713. doi:10.1101/cshperspect.a018713.</ref>. 

=== '''References''' ===

<references /><br>

PS432

2017-12-05T17:44:44Z

170094085:

PS432

2017-12-05T17:44:26Z

170094085:

PS432 is a molecule which has shown great promise in targeted cancer therapy as it was shown to dramatically reduce the rate of cell division in cancer cells, resulting in declining tumour growth. It does this by allosteric inhibition of protein kinase C <ref>ACS Chem. Biol., 2017, 12 (2), pp 564–573, Arencibia, J., Fröhner, W., Krupa, M., Pastor-Flores, D., Merker, P., Oellerich, T., Neimanis, S., Schmithals, C., Köberle, V., Süß, E., Zeuzem, S., Stark, H., Piiper, A., Odadzic, D., Schulze, J. and Biondi, R. (2017). An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. [online] PUBCS. [Cited 05/12/17] Available at: http://pubs.acs.org/doi/abs/10.1021/acschembio.6b00827</ref>   PS432 has an empirical formula of C23H19CLN205S with a molecular weight of 494.95 daltons  <ref>PS432 has an empirical formula of C23H19CLN205S with a molecular weight of 494.95 daltons <ref>Sigma-Aldrich. (2017). PS432 SML1991. [online] Available at: https://www.sigmaaldrich.com/catalog/product/sigma/sml1991?lang=en&region=GB [Accessed 5 Dec. 2017]</ref>.</ref>

<references />

1. ACS Chem. Biol., 2017, 12 (2), pp 564–573, Arencibia, J., Fröhner, W., Krupa, M., Pastor-Flores, D., Merker, P., Oellerich, T., Neimanis, S., Schmithals, C., Köberle, V., Süß, E., Zeuzem, S., Stark, H., Piiper, A., Odadzic, D., Schulze, J. and Biondi, R. (2017). An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. [online] PUBCS. [Cited 05/12/17] Available at: http://pubs.acs.org/doi/abs/10.1021/acschembio.6b00827

2. PS432 has an empirical formula of C23H19CLN205S with a molecular weight of 494.95 daltons <ref>Sigma-Aldrich. (2017). PS432 SML1991. [online] Available at: https://www.sigmaaldrich.com/catalog/product/sigma/sml1991?lang=en&region=GB [Accessed 5 Dec. 2017]</ref>.

PS432

2017-12-05T17:42:41Z

170094085:

PS432 is a molecule which has shown great promise in targeted cancer therapy as it was shown to dramatically reduce the rate of cell division in cancer cells, resulting in declining tumour growth. It does this by allosteric inhibition of protein kinase C  <references />  PS432 has an empirical formula of C23H19CLN205S with a molecular weight of 494.95 daltons  <references />

PS432

2017-12-05T17:42:16Z

170094085: Created page with "PS432 is a molecule which has shown great promise in targeted cancer therapy as it was shown to dramatically reduce the rate of cell division in cancer cells, resulting in declin..."