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Proteomics

2017-10-18T13:48:57Z

170256085:

Proteomics is the study of total [[Protein|proteins]] which is expressed by a [[Cell|cell]], tissue or an [[Organism|organism]]<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. It can also be defined as the study of the [[Proteome|proteome]]. The proteome is the total set of [[Protein|proteins]] encoded by the [[Genome|genome]] of an [[Organism|organism]]. Meanwhile, [[Genomics|genomics]] is the study of structure and roles of the whole [[Gene|gene]] products<ref>Primrose S.B. , Twyman R.M. (2003). Principle of Genome Analysis and Genomics, 3rd Edition, Hong Kong: Graphicraft Limited. Page 9</ref>. There are a few crucial differences between proteomics and [[Genomics|genomics]]. In biological fluids such as [[Plasma|plasma]], [[Serum|serum]], [[Urine|urine]], cells and tissues, a marker called as "Proteomic biomarkers" is used to mark the [[Molecules|molecules]]<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. Besides, if there is a stimuli from the environment or surroundings, the proteome (proteins) will react with the stimuli and keep changing in constant<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. In certain diseases or stages of development, the protein complement of a cell may change, and comparing the proteomes of cells can be helpful in understanding what is happening to that cell. Furthermore, in every cells or tissues, the proteome is different from each other due to different genes carried<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. Existence of [[Post-translational modification|post-translational modifications]] and protein conformation will cause in addition of the complexity<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. Thus, only Polymerase Chain Reaction ([[PCR]])  produces total of proteome faster and ease to amplify them to an assay<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. These reasons proves that the proteome potrays the transcriptome more than the genome itself<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>.<br>

=== Reference ===

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Proteomics

2017-10-18T13:48:30Z

170256085:

Proteomics is the study of total [[Protein|proteins]] which is expressed by a [[Cell|cell]], tissue or an [[Organism|organism]]<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. It can also be defined as the study of the [[Proteome|proteome]]. The proteome is the total set of [[Protein|proteins]] encoded by the [[Genome|genome]] of an [[Organism|organism]]. Meanwhile, [[Genomics|genomics]] is the study of structure and roles of the whole [[Gene|gene]] products<ref>Primrose S.B. , Twyman R.M. (2003). Principle of Genome Analysis and Genomics, 3rd Edition, Hong Kong: Graphicraft Limited. Page 9</ref>. There are a few crucial differences between proteomics and [[Genomics|genomics]]. In biological fluids such as [[Plasma|plasma]], [[Serum|serum]], [[Urine|urine]], cells and tissues, a marker called as "Proteomic biomarkers" is used to mark the [[Molecules|molecules]]<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. Besides, if there is a stimuli from the environment or surroundings, the proteome (proteins) will react with the stimuli and keep changing in constant<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. In certain diseases or stages of development, the protein complement of a cell may change, and comparing the proteomes of cells can be helpful in understanding what is happening to a cell. Furthermore, in every cells or tissues, the proteome is different from each other due to different genes carried<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. Existence of [[Post-translational modification|post-translational modifications]] and protein conformation will cause in addition of the complexity<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. Thus, only Polymerase Chain Reaction ([[PCR]])  produces total of proteome faster and ease to amplify them to an assay<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>. These reasons proves that the proteome potrays the transcriptome more than the genome itself<ref>Trent, R.J. (2012) Molecular Medicine Genomics to personalized healthcare: Proteomics, 4th Edition, USA :Elsevier. Chapter 4, Page 137</ref>.<br>

=== Reference ===

<references />