Xenophagy

2018-12-06T18:43:46Z

170288651: Created page with "Xenophagy is the process of Autophagy by which cytosolic or vacuole-dwelling pathogens are degraded<ref>Leigh A. Knodler and Jean Celli. Eating the strangers within: host con..."

Xenophagy is the process of [[Autophagy]] by which cytosolic or vacuole-dwelling pathogens are degraded<ref>Leigh A. Knodler and Jean Celli. Eating the strangers within: host control of intracellular bacteria via xenophagy. Cell Microbiol. 2011. 9, 1319-1327</ref>. These pathogens are recognised non-specifically by their lipopolysaccharide or peptidoglycan outer layers and are resultantly engulphed into autophagosomes (double-membraned organelles)<ref>Leigh A. Knodler and Jean Celli. Eating the strangers within: host control of intracellular bacteria via xenophagy. Cell Microbiol. 2011. 9, 1319-1327</ref>. This autophagosome migrates to and fuses with a lysosome, releasing its contents into the lysosome where they are then hydrolysed by degradative enzymes<ref>Cell Research: Yuchen Feng, Ding He, Zhiyuan Yao & Daniel J Klionsky: The machinery of macroautophagy: 2013 [cited 20/11/2018]
Available from:
https://www.nature.com/articles/cr2013168#abstract</ref>.

Xenophagy plays a key role in innate immunity - pathogens can be recognised by general pathogenic characteristics and destroyed before they cause infection in cells, thus an immune response is not required<ref>Leigh A. Knodler and Jean Celli. Eating the strangers within: host control of intracellular bacteria via xenophagy. Cell Microbiol. 2011. 9, 1319-1327</ref>.

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Xenophagy