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Preganglionic neuron

2018-10-23T09:27:33Z

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The preganglionic neuron is the first efferent neuron in a series of two found in the [[Autonomic Nervous System|autonomic nervous system]]. Originating in the [[Central nervous system|CNS]], the preganglionic neuron has its axon terminal in the autonomic ganglion where it will synapse with a [[Postganglionic neuron|postganglionic neuron]] cell body<ref>Dee Unglaub Silverthorn, 2009. Human Physiology: An Integrated Approach (5th Edition). Benjamin Cummings. Chapter 11, page 388.</ref>.

[[Image:8248-004-9927D90E.jpg]]<ref>Encyclopaedia Britannica, Inc (n.d.). Preganglionic neuron. [image] Available at: https://www.britannica.com/science/preganglionic-neuron [Accessed 19 Oct. 2018].</ref>

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Preganglionic neuron

2018-10-19T17:07:12Z

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The preganglionic neuron is the first efferent neuron in a series of two found in the [[Autonomic Nervous System|autonomic nervous system]]. Originating in the [[Central nervous system|CNS]], the preganglionic neuron has its axon terminal in the autonomic ganglion where it will synapse with a [[Postganglionic neuron|postganglionic neuron]] cell body <ref>Dee Unglaub Silverthorn, 2009. Human Physiology: An Integrated Approach (5th Edition). Benjamin Cummings. Chapter 11, page 388.</ref>.<ref>Encyclopaedia Britannica, Inc (n.d.). Preganglionic neuron. [image] Available at: https://www.britannica.com/science/preganglionic-neuron [Accessed 19 Oct. 2018].</ref>

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Preganglionic neuron

2018-10-19T17:00:16Z

170366823:

The preganglionic neuron is the first efferent neuron in a series of two found in the [[Autonomic Nervous System|autonomic nervous system]]. Originating in the [[Central nervous system|CNS]], the preganglionic neuron has its axon terminal in the autonomic ganglion where it will synapse with a [[Postganglionic neuron|postganglionic neuron]] cell body <ref>Dee Unglaub Silverthorn, 2009. Human Physiology: An Integrated Approach (5th Edition). Benjamin Cummings. Chapter 11, page 388.</ref>.[[Image:8248-004-9927D90E.jpg|Pre and Post-Ganglionic neurons leading from CNS to target organs with different receptors]]

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File:8248-004-9927D90E.jpg

2018-10-19T16:55:38Z

170366823: Pre and Post ganglionic receptors leading from CNS to the target organ

Pre and Post ganglionic receptors leading from CNS to the target organ

GLUT3

2017-12-06T10:53:54Z

170366823: Added 3 ref's. Added some information.

GLUT3 is a [[Glucose transporter|glucose transporter]] within cell membranes. It is one of 14 Na<sup>+</sup> independent facilitated diffusion transporters<ref>Cura, Anthony J., and Anthony Carruthers. “The Role of Monosaccharide Transport Proteins in Carbohydrate Assimilation, Distribution, Metabolism and Homeostasis.” Comprehensive Physiology 2.2 (2012): 863–914. PMC. Web. 6 Dec. 2017.</ref>, termed [[GLUT1|GLUT1]] to [[GLUT14|GLUT14]]. As it is a facilitated diffusion transporter, it relies on a concentration gradient for transport of glucose.

GLUT3 binds to [[Glucose|glucose]] in the extracellular space (e.g. [[Blood|blood]]) which induces a conformational change. This conformational change transports the glucose across the cell membrane.

GLUT3 is primarily involved in glucose transport for neurones<ref>Expression of two glucose transporters, GLUT1 and GLUT3, in cultured cerebellar neurons: Evidence for neuron-specific expression of GLUT3.fckLRF. Maher, T. M. Davies-Hill, P. G. Lysko, R. C. Henneberry, I. A. SimpsonfckLRMol Cell Neurosci. 1991 Aug; 2(4): 351–360.</ref> and, unlike some transporters, principally tranports glucose to within the cells, rather than bidirectionally.

Another role of GLUT3 that has been investigated is it's part in early embryonic development, as research indicates that if the gene encoding the GLUT3 protein is deleted, then there is severe development issues and problems.<ref>Schmidt, S et al. “Essential Role of Glucose Transporter GLUT3 for Post-Implantation Embryonic Development.” The Journal of Endocrinology 200.1 (2009): 23–33. PMC. Web. 6 Dec. 2017.</ref>

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GLUT3

2017-12-06T10:45:56Z

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GLUT3

2017-12-06T10:39:52Z

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