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Vancomycin

2018-12-06T12:31:15Z

180030389:

'''Vancomycin''' is a complex [[Glycopeptide|glycopeptide]] <ref name="(1)">University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018];fckLRAvailable from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref> produced by the soil [[Bacteria|bacterium ]][[Amycolatopsis orientalis|Amycolatopsis orientalis]] <ref name="(2)">European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018];fckLRAvailable from:fckLRhttps://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref> . It is also known as 'Mississippi Mud' due to its dark colour and its general appearance when extracted as a natural product<ref name="(3)">Hamilton.Students Researching Vancomycin Structure. 2009 [cited 06/12/2018];fckLRAvailable from: https://www.hamilton.edu/news/story/students-researching-vancomycin-structure</ref>. Its main usage is as an [[Antibiotic|antibiotic]], often given intravenously, used to treat skin infections, endocarditis, bloodstream infections, bone and joint infections and [[Meningitis|meningitis]] caused by the methicillin-resistant [[Staphylococcus aureus|Staphylococcus aureus]]  <ref name="(2)">European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018];fckLRAvailable from: https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref>.   

= ''Mechanism of action as an antibiotic'' =

Vancomycin works by inhibiting the synthesis of the bacterial [[Cell wall|cell wall]], specifically by averting the reaction implying the linkage between the [[Peptidoglycan|peptidoglycan]] precursors. In comparison to other antibiotics such as [[Penicillin|penicillin]], this drug binds to the [[Substrate|substrate]] (D-alanyl-D-alanine terminal dipeptide of peptidoglycan precursors) , not the [[Enzyme|enzyme]] in order to inhibit the synthesis of the cell wall.  This antibiotic has a great effect on [[Gram positive bacteria|Gram-positive]][[Gram positive bacteria| bacteria]], which use the thick peptidoglycan cell wall for protection, but recently bacteria have been developing [[Antibiotic resistance|resistance]] to it, so scientists are obliged to look for alternatives<ref name="(1)">University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018];fckLRAvailable from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref> .

= ''Alternatives'' =

A new version of Vancomycin is being worked on that implies the introduction of a not often seen [[Carbohydrate|carbohydrate]] group, respectively seven-membered rings, which will hopefully be different enough for bacteria not to recognise<ref name="(3)">Hamilton. Students Researching Vancomycin Structure. 2009 [cited 06/12/2018];fckLRAvailable from: https://www.hamilton.edu/news/story/students-researching-vancomycin-structure</ref>.

= ''References'' =

''<references />''

Vancomycin

2018-12-06T12:29:09Z

180030389:

'''Vancomycin''' is a complex [[Glycopeptide|glycopeptide]] <ref name="(1)">University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018];Available from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref> produced by the soil [[Bacteria|bacterium ]][[Amycolatopsis orientalis|Amycolatopsis orientalis]] <ref name="(2)">European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018];fckLRAvailable from:fckLRhttps://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref> . It is also known as 'Mississippi Mud' due to its dark colour and its general appearance when extracted as a natural product<ref name="(3)">Hamilton.Students Researching Vancomycin Structure. 2009 [cited 06/12/2018];fckLRAvailable from: https://www.hamilton.edu/news/story/students-researching-vancomycin-structure</ref>. Its main usage is as an [[Antibiotic|antibiotic]], often given intravenously, used to treat skin infections, endocarditis, bloodstream infections, bone and joint infections and [[Meningitis|meningitis]] caused by the methicillin-resistant [[Staphylococcus aureus|Staphylococcus aureus]]  <ref name="(2)">European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018];fckLRAvailable from: https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref>.   

= ''Mechanism of action as an antibiotic'' =

Vancomycin works by inhibiting the synthesis of the bacterial [[Cell wall|cell wall]], specifically by averting the reaction implying the linkage between the [[Peptidoglycan|peptidoglycan]] precursors. In comparison to other antibiotics such as [[Penicillin|penicillin]], this drug binds to the [[Substrate|substrate]] (D-alanyl-D-alanine terminal dipeptide of peptidoglycan precursors) , not the [[Enzyme|enzyme]] in order to inhibit the synthesis of the cell wall.  This antibiotic has a great effect on [[Gram positive bacteria|Gram-positive]][[Gram positive bacteria| bacteria]], which use the thick peptidoglycan cell wall for protection, but recently bacteria have been developing [[Antibiotic resistance|resistance]] to it, so scientists are obliged to look for alternatives<ref name="(1)">University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018];fckLRAvailable from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref> .

= ''Alternatives'' =

A new version of Vancomycin is being worked on that implies the introduction of a not often seen [[Carbohydrate|carbohydrate]] group, respectively seven-membered rings, which will hopefully be different enough for bacteria not to recognise<ref name="(3)">Hamilton. Students Researching Vancomycin Structure. 2009 [cited 06/12/2018];fckLRAvailable from: https://www.hamilton.edu/news/story/students-researching-vancomycin-structure</ref>.

= ''References'' =

''<references />''

Vancomycin

2018-12-06T12:23:26Z

180030389: Created page with "'''Vancomycin''' is a complex glycopeptide <ref name="(1)">University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018];Available from: h..."

'''Vancomycin''' is a complex [[Glycopeptide|glycopeptide]] <ref name="(1)">University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018];Available from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref> produced by the soil [[Bacteria|bacterium ]][[Amycolatopsis orientalis|Amycolatopsis orientalis<ref name="(2)">European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018];fckLRAvailable from:fckLRhttps://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref>]] . It is also known as 'Mississippi Mud' due to its dark colour and its general appearance when extracted as a natural product<ref name="(3)">Hamilton.Students Researching Vancomycin Structure. 2009 [cited 06/12/2018];fckLRAvailable from: https://www.hamilton.edu/news/story/students-researching-vancomycin-structure</ref>. Its main usage is as an [[Antibiotic|antibiotic]], often given intravenously, used to treat skin infections, endocarditis, bloodstream infections, bone and joint infections and [[Meningitis|meningitis]] caused by the methicillin-resistant [[Staphylococcus aureas|Staphylococcus aureus<ref name="(2)">European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018];fckLRAvailable from: https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref>]]. 

= ''Mechanism of action as an antibiotic'' =

Vancomycin works by inhibiting the synthesis of the bacterial [[Cell wall|cell wall]], specifically by averting the reaction implying the linkage between the [[Peptidoglycan|peptidoglycan]] precursors. In comparison to other antibiotics such as [[Penicillin|penicillin]], this drug binds to the [[Substrate|substrate]] (D-alanyl-D-alanine terminal dipeptide of peptidoglycan precursors) , not the [[Enzyme|enzyme]] in order to inhibit the synthesis of the cell wall.  This antibiotic has a great effect on [[Gram positive bacteria|Gram-positive]][[Gram positive bacteria| bacteria]], which use the thick peptidoglycan cell wall for protection, but recently bacteria have been developing [[Antibiotic resistance|resistance]] to it, so scientists are obliged to look for alternatives <ref name="(1)">University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018];fckLRAvailable from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref>.

= ''Alternatives'' =

A new version of Vancomycin is being worked on that implies the introduction of a not often seen [[Carbohydrate|carbohydrate]] group, respectively seven-membered rings, which will hopefully be different enough for bacteria not to recognise<ref name="(3)">Hamilton. Students Researching Vancomycin Structure. 2009 [cited 06/12/2018];fckLRAvailable from: https://www.hamilton.edu/news/story/students-researching-vancomycin-structure</ref>.

= ''References'' =

''<references />''