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Poliomyelitis

2018-11-27T12:49:29Z

180658150:

Polio is a highly contagious [[Picornavirus|picornavirus]], though only a few patients develop any illness from the infection.

'''''Spread''''': Droplet or faecal-oral.

'''''Incubation: '''''7 days.

'''''Signs:''''' ''Flu prodrome'' for 48h then ''pre-paralytic stage: ''T°, pulse, headache, vomiting, neck stiffness and unilateral tremor. In <50% this progresses to a ''paralytic stage'': myalgia, LMN signs ± respiratory failure. No sensory signs.

'''''Test:''''' CSF: WCC, polymorphs then [[Lymphocytes|lymphocytes]], otherwise normal; paired [[Sera|sera]] (14 days apart); throat swab and stool culture identify [[Virus|virus]].

'''''Natural history: '''''<10% of those with paralysis die. There maybe delayed progression of paralysis ('''''post-polio syndrome''''', PPS). Risk of severe paralysis in adults; pregnant; [[Muscle|muscle]] fatigue/trauma during incubation period. '''''PPS''''' causes fatigue, weakness, [[Myalgia|myalgia]], and worsening function, not necessarily at sites originally affected (advise enough exercise to prevent wasting but no so at sites originally affected (advise enough exersice to prevent wasting but not so much as to weaknessin aldready damaged muscles)). No drug works.

'''''Vaccine:''''' p391

'''''Reference:'''''

<ref>www.oup.com/uk/ohcm9refs</ref><references /><br>

Poliomyelitis

2018-11-27T07:59:04Z

180658150:

Polio is a highly contagious picornavirus,though only a few patients develop any illness from the infection.

'''''Spread''''': Droplet or faecal-oral.

'''''Incubation:'''''7 days.

'''''Signs:''''' ''Flu prodrome'' for 48h then ''pre-paralytic stage:''T°,pulse,headache,vomiting,neck stiffness and unilateral tremor. In <50% this progresses to a ''paralytic stage'':myalgia,LMN signs ± respiratory failure.No sensory signs.

'''''Test:''''' CSF:WCC,polymorphs then lymphocytes,otherwise normal;paired sera(14 days apart);throat swab and stool culture identify virus.

'''''Natural history:'''''<10% of those with paralysis die.There maybe delayed progression of paralysis('''''post-polio syndrome''''',PPS).Risk of severe paralysisif Adults;pregnant;muscle fatigue/trauma during incubation period.'''''PPS''''' causes fatigue,weakness,myalgia, and worsening function,not necessarily at sites originally affected(advise enough exercise to prevent wasting but no so at sites originally affected(advise enough exersice to prevent wasting but not so much as to weaknessin aldready damaged muscles).No drug works.

'''''Vaccine:''''' p391

Poliomyelitis

2018-11-27T07:55:30Z

180658150: Created page with "Polio is a highly contagious picornavirus,though only a few patients develop any illness from the infection.'''''Spread''''': Droplet or faecal-oral.'''''Incubation:'''''7 days.'..."

Polio is a highly contagious picornavirus,though only a few patients develop any illness from the infection.'''''Spread''''': Droplet or faecal-oral.'''''Incubation:'''''7 days.'''''Signs:''''' ''Flu prodrome'' for 48h then ''pre-paralytic stage:''T°,pulse,headache,vomiting,neck stiffness and unilateral tremor. In <50% this progresses to a ''paralytic stage'':myalgia,LMN signs ± respiratory failure.No sensory signs.'''''Test:''''' CSF:WCC,polymorphs then lymphocytes,otherwise normal;paired sera(14 days apart);throat swab and stool culture identify virus.'''''Natural history:'''''<10% of those with paralysis die.There maybe delayed progression of paralysis('''''post-polio syndrome''''',PPS).Risk of severe paralysisif Adults;pregnant;muscle fatigue/trauma during incubation period.'''''PPS''''' causes fatigue,weakness,myalgia, and worsening function,not necessarily at sites originally affected(advise enough exercise to prevent wasting but no so at sites originally affected(advise enough exersice to prevent wasting but not so much as to weaknessin aldready damaged muscles).No drug works. '''''Vaccine:''''' p391