Ribonuclease H

2018-11-22T06:10:36Z

180658378: Created page with " <ref>Hartmann G. Nucleic Acid Immunity. Advances in Immunology. 2017;133:121-169 Available at: https://www.sciencedirect.com/science/article/pii/S0065277616300529</ref>Ribo..."

 <ref>Hartmann G. Nucleic Acid Immunity. Advances in Immunology. 2017;133:121-169 Available at: https://www.sciencedirect.com/science/article/pii/S0065277616300529</ref>Ribonuclease H also known as RNase H is an [[Enzyme|enzyme]] that remove the [[RNA primer|RNA primers]] on the lagging strand during DNA replication. RNA primers are replaced with nucleotides between the Okazaki fragments. <ref>Berg J M, Tymoczko J L, Gatto, Jr G J, Stryer L. Biochemistry Eighth Edition. 2015. W.H. Freeman and Company. New York. Pg 840-842</ref>During [[DNA replication|DNA replication]], the synthesis of new strand of DNA on the [[Lagging strand|lagging strand]] is discontinuously due to formation of [[Okazaki fragment|Okazaki Fragment]]. RNase H will cleave the RNA primers from the Okazaki fragment and replace it with DNA. [[DNA ligase|DNA ligase]] can from [[Phosphodiester bond|phosphodiester bond]] between the nucleotides added and the Okazaki fragment. This result in the formation of complete continuous strand of new DNA.

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Ribonuclease H