View source for EPP

EPPs (end plate potential) are the depolarisations in the skeletal muscle caused by neurotransmitters such as [[Acetylcholine|Ach]]&nbsp;binding to the postsynaptic membrane in the [[Neuromuscular junction|neuromuscular junction]]. 

When Ach is released from the presynaptic membrane, it binds to channel-shaped receptor molecules on the end plate, opening the channels and allowing positively charged sodium ions to flow into the muscle cell, which causes the&nbsp;membrane to depolarise slightly.&nbsp;An enzyme called acetylcholinesterase&nbsp;then rapidly degrades the acetylcholine, so they can diffuse back to the presynaptic knob, closing the channels and allowing the membrane to return to its previous polarised state. <ref>Alberts, Johnson, Lewis, Morgan, Raff, Roberts and Walter (2015) Molecular biology of the cell 6th Edition. New York. Garland Science, Taylor and Francis Group.</ref> 

<br>

=== References:  ===

<references />