View source for T-SNARES

T-SNAREs (Target-Soluble NSF Attachment Receptor) is one specific part of conglomerate of [[Proteins|proteins]] that make up cell or [[Organelles|organelle]] [[Membranes|membranes]], where these proteins are involved directly in [[Membrane fusion|membrane fusion]] between, usually, the membranes of a [[Vesicles|vesicle]] and the cell's membrane in the process of [[Endocytosis|endocytosis]]. A T-SNARE is found on the target membrane in the [[Endocytosis|endocytosis]] of a certain substance, where it is commonly made up of three proteins. These T-SNARES will combine with V-SNARES (Vesicle) to create a Trans-SNARE complex which is a four [[Alpha_helix|alpha helix]] bundle which is stable, this will then allow eventually the two membranes to fuse and a fusion pore to open, causing the vesicular contents to [[Diffusion|diffuse]] into the cell. The energy for this membrane fusion is thought to come from the conformational change when the helices, from either transport or vesicular SNAREs, combine to form a complex, releasing energy. T-SNARES usually have an inhibitory complex bound to them, therefore[[Rab|Rab ]]proteins and their effector proteins are needed to rid of this inhibitor, so that T-SNARES and V-SNARES can bind together, however specific extracellular signals are what initiate the binding of the two SNARE types, Rab proteins only increase the rate at which they bind<ref>Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. 6th Ed, New York: Garland Science, Taylor and Francis Group. 2015;13:708-709</ref>. 

<span style="font-size: 13.28px;">This process is constantly occuring in the nervous system where, for example in a [[Ion-channel-coupled_receptor|cholinergic synapse]], [[Acetylcholine|acetylcholine ]]is being transmitted across the presynaptic cleft for transmission to the post synaptic [[Neurone|neurone]], where on the vesicle there is the SNARE protein synaptobrevin, and on the target membrane there SNARE proteins SNAP 25 and [[Syntaxin|Syntaxin]]<ref>Burkhardt P, Hattendorf DA, Weis WI, Fasshauer D (2008). "Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide". EMBO J. 27 (7): 923–33</ref>.</span> 

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