View source for ATR

ATR is a [[Protein kinase|protein kinase]] enzyme which recognises a range of [[DNA|DNA]] damage and recruits adaptor proteins and more protein kinases ([[Chk1|Chk1]] and [[Chk2|Chk2]])&nbsp; which then go on to activate repair mechanisms or cause [[Apoptosis|apoptosis]] or [[Cell cycle|cell cycle]] arrest. ATR is homologous to ATM, however ATM only recognises double-stranded DNA breaks whereas ATR can recognise stalled [[Replication forks|replication forks]], damaged [[Nucleotides|nucleotides]], double-stranded breaks and more<ref name="(1)">H. Lodish, C. A. Kaiser, A. Berk, M. Krieger, A. Bretscher, H. Ploegh, A. Amon, M. P. Scott. Molecular Cell Biology. 7th Ed. New York: W. H. Freeman. 2013.</ref>. 

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