View source for Enac

Enac is a [[Na+ channel|Na]]<sup>[[Na+ channel|+]]</sup>[[Na+ channel|channel]], it can be mutated and cause [[Liddle Syndrome|Liddle Syndrome]]. 

ENac is important in [[Cystic fibrosis|Cystic Fibrosis]] too, usually it is inhibited by the [[CFTR|CFTR]] channel but when the patient has [[Cystic Fibrosis|CF]] ENac loses it's inhibition and lets many Na<sup>+</sup> [[Ions|ions]] into the cell - this leads to a higher open state probability for the Na<sup>+</sup> channels in the cell. 

EnaC is inhibited by [[Amiloride|amiloride]], which is a K<sup>+</sup> sparing [[Diuretic|diuretic]], this means that the movement of Na<sup>+</sup> is inhibited without disrupting the movement of K<sup>+</sup> which is beneficial for [[Liddle Syndrome|Liddle's Syndrome]] as they are [[Hypokalemic|hypokalemic]].