View source for DNA helicase

DNA helicase is an enzyme responsible for the separation of two annealed strands of nucleic acids. This process allows a single-stranded [[DNA|DNA]] to form and be used as a template during [[Transcription|transcription]]. ATP hydrolysis provides the energy for the enzyme to translocate along the double helix and generate a replication fork<ref>Alberts, Johnson, Lewis, Raff, Roberts, Walters. (2008) Molecular Biology of the Cell: 273, 5th edition, New York: Garland Science.</ref>. In [[E.Coli|E.coli]] DNA helicase is called the DnaB protein, and it differs slightly in the way it carries out it's function. DnaB forms a three-fold ring structure, with the lagging strand binding in the central region, whilst the leading strand is excluded. The DnaB translocates through a mechanism where dNTP's bind and cause a conformational change, forcing the DNA strands to separate<ref>Alberts, Johnson, Lewis, Raff, Roberts, Walters. (2008) Molecular Biology of the Cell: 283, 5th edition, New York: Garland Science.</ref>. <br> 



=== References ===

<references />