View source for GEF

GEF, also known as Sos, is a protein linked with the [[Ras pathway|RAS pathway]]. It opens up the nucleotide-binding pocket of [[Ras|Ras]]. This releases [[GDP|GDP]] and allows [[GTP|GTP]] to attach to Ras, thus activating it&nbsp;<ref>Berg J, Stryer L, Tymoczko J. (2011) Biochemistry, 7th Edition. International Edition, Basingstoke: Palgrave Macmillan. Page 431.</ref>.

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