View source for Recepter Tyrosine Kinases

Receptor tyrosine kinases activate tyrosine kinase [[enzymes|enzymes]] which have [[intrinsic enzymatic activity|intrinsic enzymatic activity]], and is part of the receptor's [[polypeptide chain|polypeptide chain]] therefore encoded by the same [[gene|gene]]<ref>Lodish H, Kaiser CA, Bretcher A, Amon A, Berk A, Kneger M, Ploegh H, Scott MP. Molecular Cell Biology. 7th Ed, New York: W.H. Freeman and Company. 2013.</ref>. It is the most common type of enzyme linked receptors, including [[insulin receptor|insulin receptors]] and many [[growth factor receptor|growth factor receptors]]. Growth factor receptors control [[cell differentiation|cell differentiation]] and [[cell proliferation|proliferation]], which is frequently associated with [[cancer|cancer]]. 

Ligand binding to the extra-cellular domain induces the formation of receptor dimers - the process of two or more receptors joining together is known as 'activation by receptor oligomerization'<ref>Lodish H, Kaiser CA, Bretcher A, Amon A, Berk A, Kneger M, Ploegh H, Scott MP. Molecular Cell Biology. 7th Ed, New York: W.H. Freeman and Company. 2013</ref>. Activated receptor chains [[Autophosphorylate|autophosphorylate]], which allows them to act as docking sites for other signalling proteins.<br> 

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