5' cap - Revision history

Nnjm2 at 20:29, 6 December 2018

2018-12-06T20:29:25Z

← Older revision		Revision as of 20:29, 6 December 2018
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	Eukaryotic [[~~pre~~-mRNA\|pre-mRNA]] goes through a process of modification before it is able to bind to the [[~~rRNA~~\|ribosomal RNA]]. This modification also adds stability and plays an important role in the removal of [[Introns\|introns]] in the [[Pre-mRNA\|pre-mRNA]]. The process of cap addition takes place rapidly after [[Transcription\|transcription]] is initiated, the addition of a~~<span style="font-size: 13.28px;"> </span>~~[[Guanine\|~~<span style="font-size: 13.28px;">~~guanine~~</span><span style="font-size: 13.28px;"> </span>~~]]~~<span style="font-size: 13.28px;">~~base to the 5’ end of the [[~~mRNA~~\|mRNA]], followed by the addition of [[~~Methyl_group~~\|methyl groups]] (CH<sub>3</sub>) to the [[~~guanine~~\|guanine]] and the bases of one or two bases at the 5’ end of the [[~~mRNA~~\|mRNA]]. Unlike the rest of the bases in [[RNA\|RNA]] the [[~~guanine~~ base\|guanine base]] constituting the 5’ cap is connected to the RNA by a 5’-5’ bond. The methyl groups are then added to position 7 on the [[~~guanine~~ nucleotide\|guanine nucleotide]]. Cap binding proteins then bind this structure allowing recognition by the ribosomal RNA. The rRNA will then move downstream until it reaches the [[~~start~~ codon\|start codon]], initiating translation. The addition of this cap is catalysed by the enzyme that associates with [[RNA polymerase II\|RNA polymerase II]]. [[RNA polymerase I\|RNA polymerase I]] and [[~~RNA_polymerase_III~~\|III]] do not have this property and so RNAs modified by these enzymes don’t have the 5’ cap.~~</span>~~		Eukaryotic [[Pre-mRNA\|pre-mRNA]] goes through a process of modification before it is able to bind to the [[RRNA\|ribosomal RNA]]. This modification also adds stability and plays an important role in the removal of [[Introns\|introns]] in the [[Pre-mRNA\|pre-mRNA]]. The process of cap addition takes place rapidly after [[Transcription\|transcription]] is initiated, the addition of a [[Guanine\|guanine ]]base to the 5’ end of the [[MRNA\|mRNA]], followed by the addition of [[Methyl group\|methyl groups]] (CH<sub>3</sub>) to the [[Guanine\|guanine]] and the bases of one or two bases at the 5’ end of the [[MRNA\|mRNA]]. Unlike the rest of the bases in [[RNA\|RNA]] the [[Guanine base\|guanine base]] constituting the 5’ cap is connected to the RNA by a 5’-5’ bond. The methyl groups are then added to position 7 on the [[Guanine nucleotide\|guanine nucleotide]]. Cap-binding proteins then bind this structure allowing recognition by the ribosomal RNA. The rRNA will then move downstream until it reaches the [[Start codon\|start codon]], initiating translation. The addition of this cap is catalysed by the enzyme that associates with [[RNA polymerase II\|RNA polymerase II]]. [[RNA polymerase I\|RNA polymerase I]] and [[RNA polymerase III\|III]] do not have this property and so RNAs modified by these enzymes don’t have the 5’ cap.

	~~<br>~~

Nnjm2: Added some links. Needs references.

2018-12-06T20:29:05Z

Added some links. Needs references.

← Older revision		Revision as of 20:29, 6 December 2018
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	~~ ~~Eukaryotic pre-mRNA goes through a process of modification before it is able to bind to the ribosomal RNA. This modification also adds stability and plays an important role in the removal of [[Introns\|introns]] in the [[Pre-mRNA\|pre-mRNA]]. The process of cap addition takes place rapidly after [[Transcription\|transcription]] is initiated, the addition of a<span style="font-size: 13.28px;"> </span>[[Guanine\|<span style="font-size: 13.28px;">guanine</span><span style="font-size: 13.28px;"> </span>]]<span style="font-size: 13.28px;">base to the 5’ end of the mRNA, followed by the addition of methyl groups (~~CH3~~) to the guanine and the bases of one or two bases at the 5’ end of the mRNA ~~(see Figure 1)~~. Unlike the rest of the bases in RNA the guanine base constituting the 5’ cap is connected to the RNA by a 5’-5’ bond. The methyl groups are then added to position 7 on the guanine nucleotide. Cap binding proteins then bind this structure allowing recognition by the ribosomal RNA. The rRNA will then move downstream until it reaches the start codon, initiating translation. The addition of this cap is catalysed by the enzyme that associates with RNA polymerase II. RNA polymerase I and III do not have this property and so RNAs modified by these enzymes don’t have the 5’ cap.</span>		Eukaryotic [[pre-mRNA\|pre-mRNA]] goes through a process of modification before it is able to bind to the [[rRNA\|ribosomal RNA]]. This modification also adds stability and plays an important role in the removal of [[Introns\|introns]] in the [[Pre-mRNA\|pre-mRNA]]. The process of cap addition takes place rapidly after [[Transcription\|transcription]] is initiated, the addition of a<span style="font-size: 13.28px;"> </span>[[Guanine\|<span style="font-size: 13.28px;">guanine</span><span style="font-size: 13.28px;"> </span>]]<span style="font-size: 13.28px;">base to the 5’ end of the [[mRNA\|mRNA]], followed by the addition of [[Methyl_group\|methyl groups]] (CH<sub>3</sub>) to the [[guanine\|guanine]] and the bases of one or two bases at the 5’ end of the [[mRNA\|mRNA]]. Unlike the rest of the bases in [[RNA\|RNA]] the [[guanine base\|guanine base]] constituting the 5’ cap is connected to the RNA by a 5’-5’ bond. The methyl groups are then added to position 7 on the [[guanine nucleotide\|guanine nucleotide]]. Cap binding proteins then bind this structure allowing recognition by the ribosomal RNA. The rRNA will then move downstream until it reaches the [[start codon\|start codon]], initiating translation. The addition of this cap is catalysed by the enzyme that associates with [[RNA polymerase II\|RNA polymerase II]]. [[RNA polymerase I\|RNA polymerase I]] and [[RNA_polymerase_III\|III]] do not have this property and so RNAs modified by these enzymes don’t have the 5’ cap.</span>

	<br>		<br>

160101984 at 12:36, 6 December 2018

2018-12-06T12:36:30Z

← Older revision		Revision as of 12:36, 6 December 2018
Line 1:		Line 1:
	Eukaryotic pre-mRNA goes through a process of modification before it is able to bind to the ribosomal RNA. This modification also adds stability and plays an important role in the removal of [[Introns\|introns]] in the [[Pre-mRNA\|pre-mRNA]]. The process of cap addition takes place rapidly after [[Transcription\|transcription]] is initiated, the addition of a<span style="font-size: 13.28px;"> </span>[[Guanine\|<span style="font-size: 13.28px;">guanine</span><span style="font-size: 13.28px;"> </span>]]<span style="font-size: 13.28px;">base to the 5’ end of the mRNA, followed by the addition of methyl groups (CH3) to the guanine and the bases of one or two bases at the 5’ end of the mRNA (see Figure 1). Unlike the rest of the bases in RNA the guanine base constituting the 5’ cap is connected to the RNA by a 5’-5’ bond. The methyl groups are then added to position 7 on the guanine nucleotide. Cap binding proteins then bind this structure allowing recognition by the ribosomal RNA. The rRNA will then move downstream until it reaches the start codon, initiating translation. The addition of this cap is catalysed by the enzyme that associates with RNA polymerase II. RNA polymerase I and III do not have this property and so RNAs modified by these enzymes don’t have the 5’ cap.</span>		Eukaryotic pre-mRNA goes through a process of modification before it is able to bind to the ribosomal RNA. This modification also adds stability and plays an important role in the removal of [[Introns\|introns]] in the [[Pre-mRNA\|pre-mRNA]]. The process of cap addition takes place rapidly after [[Transcription\|transcription]] is initiated, the addition of a<span style="font-size: 13.28px;"> </span>[[Guanine\|<span style="font-size: 13.28px;">guanine</span><span style="font-size: 13.28px;"> </span>]]<span style="font-size: 13.28px;">base to the 5’ end of the mRNA, followed by the addition of methyl groups (CH3) to the guanine and the bases of one or two bases at the 5’ end of the mRNA (see Figure 1). Unlike the rest of the bases in RNA the guanine base constituting the 5’ cap is connected to the RNA by a 5’-5’ bond. The methyl groups are then added to position 7 on the guanine nucleotide. Cap binding proteins then bind this structure allowing recognition by the ribosomal RNA. The rRNA will then move downstream until it reaches the start codon, initiating translation. The addition of this cap is catalysed by the enzyme that associates with RNA polymerase II. RNA polymerase I and III do not have this property and so RNAs modified by these enzymes don’t have the 5’ cap.</span>

	<~~span style="font-size: 13.28px;" /~~>		<br>

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2018-12-06T11:28:23Z

Created page with " Eukaryotic pre-mRNA goes through a process of modification before it is able to bind to the ribosomal RNA. This modification also adds stability and plays an important role..."

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Eukaryotic pre-mRNA goes through a process of modification before it is able to bind to the ribosomal RNA. This modification also adds stability and plays an important role in the removal of [[Introns|introns]] in the [[Pre-mRNA|pre-mRNA]]. The process of cap addition takes place rapidly after [[Transcription|transcription]] is initiated, the addition of a [[Guanine|guanine ]]base to the 5’ end of the mRNA, followed by the addition of methyl groups (CH3) to the guanine and the bases of one or two bases at the 5’ end of the mRNA (see Figure 1). Unlike the rest of the bases in RNA the guanine base constituting the 5’ cap is connected to the RNA by a 5’-5’ bond. The methyl groups are then added to position 7 on the guanine nucleotide. Cap binding proteins then bind this structure allowing recognition by the ribosomal RNA. The rRNA will then move downstream until it reaches the start codon, initiating translation. The addition of this cap is catalysed by the enzyme that associates with RNA polymerase II. RNA polymerase I and III do not have this property and so RNAs modified by these enzymes don’t have the 5’ cap.