Catabolism of amino acids - Revision history

110029074 at 17:19, 1 December 2011

2011-12-01T17:19:18Z

← Older revision		Revision as of 17:19, 1 December 2011
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	The catabolic breakdown of [[Amino acids\|amino acids]] yields compounds that act as intermediates in the [[Citric acid cycle\|citric acid cycle]], whilst the [[Anabolic\|anabolic]] formation of [[~~Amino_acids~~\|amino acids]] uses citric cycle intermediates as precursors.<br>The [[Catabolism\|catabolism]] and [[Anabolism\|anabolism]] of [[~~amino~~ acids\|amino acids]] are linked but are not the exact reverse reactions of one another. For example [[Transamination\|transamination]] plays an important role in both processes, and they don’t involve the same group of [[Enzyme\|enzymes]].		The catabolic breakdown of [[Amino acids\|amino acids]] yields compounds that act as intermediates in the [[Citric acid cycle\|citric acid cycle]], whilst the [[Anabolic\|anabolic]] formation of [[Amino acids\|amino acids]] uses citric cycle intermediates as precursors.<br>The [[Catabolism\|catabolism]] and [[Anabolism\|anabolism]] of [[Amino acids\|amino acids]] are linked but are not the exact reverse reactions of one another. For example [[Transamination\|transamination]] plays an important role in both processes, and they don’t involve the same group of [[Enzyme\|enzymes]].

	A [[Glucogenic amino acid\|glucogenic amino acid]] produces [[Pyruvate\|pyruvate]] or [[Oxaloacetate\|oxaloacetate]] when broken down. [[Oxaloacetate\|Oxaloacetate]] is the starting point for the production of [[Glucose\|glucose]] via [[Gluconeogenesis\|gluconeogenesis]].<br>A [[Ketogenic amino acid\|ketogenic amino acid]] will produce [[Acetyl-CoA\|acetyl-CoA]] or [[Actoacetyl-CoA\|actoacetyl-CoA]] when broken down, which will lead to the production of [[Ketone bodies\|ketone bodies]].<br>[[~~Amino_acids~~\|Amino acids]] that have been converted to [[Acetyl-CoA\|acetyl-CoA]] and [[Acetoacteyl-CoA\|acetoacteyl-CoA]] are used as intermediates in the [[Citric acid cycle\|citric acid cycle]], but mammals cannot use them in glucose synthesis. This fact is the distinction between glucogenic and ketogenic amino acids <ref>Biochemistry (Campbell 2007, pp523-524)</ref>.		A [[Glucogenic amino acid\|glucogenic amino acid]] produces [[Pyruvate\|pyruvate]] or [[Oxaloacetate\|oxaloacetate]] when broken down. [[Oxaloacetate\|Oxaloacetate]] is the starting point for the production of [[Glucose\|glucose]] via [[Gluconeogenesis\|gluconeogenesis]].<br>A [[Ketogenic amino acid\|ketogenic amino acid]] will produce [[Acetyl-CoA\|acetyl-CoA]] or [[Actoacetyl-CoA\|actoacetyl-CoA]] when broken down, which will lead to the production of [[Ketone bodies\|ketone bodies]].<br>[[Amino acids\|Amino acids]] that have been converted to [[Acetyl-CoA\|acetyl-CoA]] and [[Acetoacteyl-CoA\|acetoacteyl-CoA]] are used as intermediates in the [[Citric acid cycle\|citric acid cycle]], but mammals cannot use them in [[Glucose\|glucose]] synthesis. This fact is the distinction between glucogenic and ketogenic amino acids <ref>Biochemistry (Campbell 2007, pp523-524)</ref>.

	=== References ===		=== References ===

	<references />		<references />

Nnjm2 at 11:59, 7 January 2011

2011-01-07T11:59:43Z

← Older revision		Revision as of 11:59, 7 January 2011
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	~~ ~~The catabolic breakdown of [[~~Amino_acids~~\|amino ~~acid~~]]s yields compounds that act as intermediates in the citric acid cycle, whilst the anabolic formation of amino acids uses citric cycle intermediates as precursors.<br>The [[Catabolism\|catabolism]] and [[Anabolism\|anabolism]] of amino acids are linked but are not the exact reverse reactions of one another. For example transamination plays an important role in both processes, and they don’t involve the same group of [[Enzyme\|enzymes]].		The catabolic breakdown of [[Amino acids\|amino acids]] yields compounds that act as intermediates in the [[Citric acid cycle\|citric acid cycle]], whilst the [[Anabolic\|anabolic]] formation of [[Amino_acids\|amino acids]] uses citric cycle intermediates as precursors.<br>The [[Catabolism\|catabolism]] and [[Anabolism\|anabolism]] of [[amino acids\|amino acids]] are linked but are not the exact reverse reactions of one another. For example [[Transamination\|transamination]] plays an important role in both processes, and they don’t involve the same group of [[Enzyme\|enzymes]].

	A glucogenic amino acid produces [[Pyruvate\|pyruvate]] or oxaloacetate when broken down. Oxaloacetate is the starting point for the production of [[Glucose\|glucose]] via [[Gluconeogenesis\|gluconeogenesis]].<br>A ketogenic amino acid will produce acetyl-CoA or actoacetyl-CoA when broken down, which will lead to the production of ketone bodies<br>Amino acids that have been converted to acetyl-CoA and acetoacteyl-CoA are used as intermediates in the citric acid cycle, but mammals cannot use them in glucose synthesis. This fact is the distinction between glucogenic and ketogenic amino acids.		A [[Glucogenic amino acid\|glucogenic amino acid]] produces [[Pyruvate\|pyruvate]] or [[Oxaloacetate\|oxaloacetate]] when broken down. [[Oxaloacetate\|Oxaloacetate]] is the starting point for the production of [[Glucose\|glucose]] via [[Gluconeogenesis\|gluconeogenesis]].<br>A [[Ketogenic amino acid\|ketogenic amino acid]] will produce [[Acetyl-CoA\|acetyl-CoA]] or [[Actoacetyl-CoA\|actoacetyl-CoA]] when broken down, which will lead to the production of [[Ketone bodies\|ketone bodies]].<br>[[Amino_acids\|Amino acids]] that have been converted to [[Acetyl-CoA\|acetyl-CoA]] and [[Acetoacteyl-CoA\|acetoacteyl-CoA]] are used as intermediates in the [[Citric acid cycle\|citric acid cycle]], but mammals cannot use them in glucose synthesis. This fact is the distinction between glucogenic and ketogenic amino acids <ref>Biochemistry (Campbell 2007, pp523-524)</ref>.

	~~-Biochemistry (Campbell 2007, pp523-524)~~		=== References ===

			<references />

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2011-01-07T11:45:23Z

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 The catabolic breakdown of [[Amino_acids|amino acid]]s yields compounds that act as intermediates in the citric acid cycle, whilst the anabolic formation of amino acids uses citric cycle intermediates as precursors.<br>The [[Catabolism|catabolism]] and [[Anabolism|anabolism]] of amino acids are linked but are not the exact reverse reactions of one another. For example transamination plays an important role in both processes, and they don’t involve the same group of [[Enzyme|enzymes]].

A glucogenic amino acid produces [[Pyruvate|pyruvate]] or oxaloacetate when broken down. Oxaloacetate is the starting point for the production of [[Glucose|glucose]] via [[Gluconeogenesis|gluconeogenesis]].<br>A ketogenic amino acid will produce acetyl-CoA or actoacetyl-CoA when broken down, which will lead to the production of ketone bodies<br>Amino acids that have been converted to acetyl-CoA and acetoacteyl-CoA are used as intermediates in the citric acid cycle, but mammals cannot use them in glucose synthesis. This fact is the distinction between glucogenic and ketogenic amino acids.

-Biochemistry (Campbell 2007, pp523-524)