Chromosome territories - Revision history

Nnjm2 at 02:50, 26 November 2014

2014-11-26T02:50:36Z

← Older revision		Revision as of 02:50, 26 November 2014
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	[[Chromosome\|Chromosome]] territories are specific regions occupied by [[Chromosomes\|chromosomes]] in the [[Nucleus\|nucleus]] during [[Interphase\|interphase]]. First developed by '''''[[Carl Rabl\|Carl Rabl]]''''' (1853-1917) in his paper '''''‘Über zelltheilung, 1885’''''',''‘Rabl orientation’ ''was confirmed later in 1982 by '''C. Cremer''' (1944-) and '''T. Cremer''' (1945-) using 'premature chromosome condensation and laser-UV-microbeam experiments' using 'Chinese hamster cells.'<ref>Cremer, T., Cremer, C., Baumann, H., Luedtke, E.K., Sperling, K., Teuber, V., Zorn, C., 1982, Rabl's model of the interphase chromosome arrangement tested in Chinese hamster cells by premature chromosome condensation and laser-UV-microbeam experiments., Human Genetics, 60(1), pp46-56. Available at: fckLRhttp://link.springer.com/article/10.1007/BF00281263</ref> Recent technological advances such as '''''‘[[FISH\|Fish]]’<ref>Available explanation at: http://www.genome.gov/10000206</ref>''''' has shown all eukaryotic [[Organism\|organisms]] territories are typically 1-2 µm in diameter and irregularly shaped with sub-domains made of individual chromosome arms.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> As well as this, chromatin folding into 'fractal globule' shapes allows distinction between chromosome territory and easy access for replication molecules plus easy unfolding for specific genes.<ref>p235, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones~~&amp;amp;amp;amp;Bartlett~~ Learning</ref> Gene dense chromosomes also tends to occupy regions near the centre of the nucleus whereas less gene dense chromosomes occupies regions near the peripheral of the nucleus <ref>p236-237, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones~~&amp;amp;amp;amp;~~Bartlett Learning</ref>. Neighbouring chromosomes can interact with each other and due to this interaction chromosomes are rendered immobile.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> However, it has become aware that chromosome arrangement in a cell is dependent on cell type/organism/tissue/if diseased and thus we are still unable to predict position.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref><br>		[[Chromosome\|Chromosome]] territories are specific regions occupied by [[Chromosomes\|chromosomes]] in the [[Nucleus\|nucleus]] during [[Interphase\|interphase]]. First developed by '''''[[Carl Rabl\|Carl Rabl]]''''' (1853-1917) in his paper '''''‘Über zelltheilung, 1885’''''',''‘Rabl orientation’ ''was confirmed later in 1982 by '''C. Cremer''' (1944-) and '''T. Cremer''' (1945-) using 'premature chromosome condensation and laser-UV-microbeam experiments' using 'Chinese hamster cells.'<ref>Cremer, T., Cremer, C., Baumann, H., Luedtke, E.K., Sperling, K., Teuber, V., Zorn, C., 1982, Rabl's model of the interphase chromosome arrangement tested in Chinese hamster cells by premature chromosome condensation and laser-UV-microbeam experiments., Human Genetics, 60(1), pp46-56. Available at: fckLRhttp://link.springer.com/article/10.1007/BF00281263</ref> Recent technological advances such as '''''‘[[FISH\|Fish]]’<ref>Available explanation at: http://www.genome.gov/10000206</ref>''''' has shown all eukaryotic [[Organism\|organisms]] territories are typically 1-2 µm in diameter and irregularly shaped with sub-domains made of individual chromosome arms.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> As well as this, chromatin folding into 'fractal globule' shapes allows distinction between chromosome territory and easy access for replication molecules plus easy unfolding for specific genes.<ref>p235, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones and Learning</ref> Gene dense chromosomes also tends to occupy regions near the centre of the nucleus whereas less gene dense chromosomes occupies regions near the peripheral of the nucleus <ref>p236-237, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones and Bartlett Learning</ref>. Neighbouring chromosomes can interact with each other and due to this interaction chromosomes are rendered immobile.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> However, it has become aware that chromosome arrangement in a cell is dependent on cell type/organism/tissue/if diseased and thus we are still unable to predict position.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref><br>

	=== References ===		=== References ===

	<references />		<references />

Nnjm2 at 02:49, 26 November 2014

2014-11-26T02:49:37Z

← Older revision		Revision as of 02:49, 26 November 2014
Line 1:		Line 1:
	[[Chromosome\|Chromosome]] territories are specific regions occupied by [[Chromosomes\|chromosomes]] in the [[Nucleus\|nucleus]] during [[Interphase\|interphase]]. First developed by '''''[[Carl Rabl\|Carl Rabl]]''''' (1853-1917) in his paper '''''‘Über zelltheilung, 1885’''''',''‘Rabl orientation’ ''was confirmed later in 1982 by '''C. Cremer''' (1944-) and '''T. Cremer''' (1945-) using 'premature chromosome condensation and laser-UV-microbeam experiments' using 'Chinese hamster cells.'<ref>Cremer, T., Cremer, C., Baumann, H., Luedtke, E.K., Sperling, K., Teuber, V., Zorn, C., 1982, Rabl's model of the interphase chromosome arrangement tested in Chinese hamster cells by premature chromosome condensation and laser-UV-microbeam experiments., Human Genetics, 60(1), pp46-56. Available at: fckLRhttp://link.springer.com/article/10.1007/BF00281263</ref> Recent technological advances such as '''''‘[[FISH\|Fish]]’<ref>Available explanation at: http://www.genome.gov/10000206</ref>''''' has shown all eukaryotic [[Organism\|organisms]] territories are typically 1-2 µm in diameter and irregularly shaped with sub-domains made of individual chromosome arms.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> As well as this, chromatin folding into 'fractal globule' shapes allows distinction between chromosome territory and easy access for replication molecules plus easy unfolding for specific genes.<ref>p235, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones&amp;amp;amp;Bartlett Learning</ref> Gene dense chromosomes also tends to occupy regions near the centre of the nucleus whereas less gene dense chromosomes occupies regions near the peripheral of the nucleus <ref>p236-237, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones&amp;amp;amp;Bartlett Learning</ref>. Neighbouring chromosomes can interact with each other and due to this interaction chromosomes are rendered immobile.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> However, it has become aware that chromosome arrangement in a cell is dependent on cell type/organism/tissue/if diseased and thus we are still unable to predict position.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref><br>		[[Chromosome\|Chromosome]] territories are specific regions occupied by [[Chromosomes\|chromosomes]] in the [[Nucleus\|nucleus]] during [[Interphase\|interphase]]. First developed by '''''[[Carl Rabl\|Carl Rabl]]''''' (1853-1917) in his paper '''''‘Über zelltheilung, 1885’''''',''‘Rabl orientation’ ''was confirmed later in 1982 by '''C. Cremer''' (1944-) and '''T. Cremer''' (1945-) using 'premature chromosome condensation and laser-UV-microbeam experiments' using 'Chinese hamster cells.'<ref>Cremer, T., Cremer, C., Baumann, H., Luedtke, E.K., Sperling, K., Teuber, V., Zorn, C., 1982, Rabl's model of the interphase chromosome arrangement tested in Chinese hamster cells by premature chromosome condensation and laser-UV-microbeam experiments., Human Genetics, 60(1), pp46-56. Available at: fckLRhttp://link.springer.com/article/10.1007/BF00281263</ref> Recent technological advances such as '''''‘[[FISH\|Fish]]’<ref>Available explanation at: http://www.genome.gov/10000206</ref>''''' has shown all eukaryotic [[Organism\|organisms]] territories are typically 1-2 µm in diameter and irregularly shaped with sub-domains made of individual chromosome arms.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> As well as this, chromatin folding into 'fractal globule' shapes allows distinction between chromosome territory and easy access for replication molecules plus easy unfolding for specific genes.<ref>p235, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones&amp;amp;amp;amp;Bartlett Learning</ref> Gene dense chromosomes also tends to occupy regions near the centre of the nucleus whereas less gene dense chromosomes occupies regions near the peripheral of the nucleus <ref>p236-237, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones&amp;amp;amp;amp;Bartlett Learning</ref>. Neighbouring chromosomes can interact with each other and due to this interaction chromosomes are rendered immobile.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> However, it has become aware that chromosome arrangement in a cell is dependent on cell type/organism/tissue/if diseased and thus we are still unable to predict position.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref><br>

	=== References ===		=== References ===

	<references />		<references />

Nnjm2 at 02:47, 26 November 2014

2014-11-26T02:47:45Z

← Older revision		Revision as of 02:47, 26 November 2014
Line 1:		Line 1:
	Chromosome territories are specific regions occupied by [[Chromosomes\|chromosomes]] in the [[Nucleus\|nucleus]] during [[Interphase\|interphase]]. First developed by '''''Carl Rabl''''' (1853-1917) in his paper '''''‘Über zelltheilung, 1885’''''',''‘Rabl orientation’ ''was confirmed later in 1982 by '''C. Cremer''' (1944-) and '''T. Cremer''' (1945-) using 'premature chromosome condensation and laser-UV-microbeam experiments' using 'Chinese hamster cells.'<ref>Cremer, T., Cremer, C., Baumann, H., Luedtke, E.K., Sperling, K., Teuber, V., Zorn, C., 1982, Rabl's model of the interphase chromosome arrangement tested in Chinese hamster cells by premature chromosome condensation and laser-UV-microbeam experiments., Human Genetics, 60(1), pp46-56. Available at: fckLRhttp://link.springer.com/article/10.1007/BF00281263</ref> Recent technological advances such as '''''~~‘Fish’~~<ref>Available explanation at: http://www.genome.gov/10000206</ref>''''' has shown all eukaryotic organisms territories are typically 1-~~2µm~~ in diameter and irregularly shaped with sub-domains made of individual chromosome arms.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> As well as this, chromatin folding into 'fractal globule' shapes allows distinction between chromosome territory and easy access for replication molecules plus easy unfolding for specific genes.<ref>p235, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones&amp;amp;Bartlett Learning</ref> Gene dense chromosomes also tends to occupy regions near the centre of the nucleus whereas less gene dense chromosomes occupies regions near the peripheral of the nucleus.<ref>p236-237, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones&amp;amp;Bartlett Learning</ref> Neighbouring chromosomes can interact with each other and due to this interaction chromosomes are rendered immobile.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> However, it has become aware that chromosome arrangement in a cell is dependent on cell type/organism/tissue/if diseased and thus we are still unable to predict position.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref>		[[Chromosome\|Chromosome]] territories are specific regions occupied by [[Chromosomes\|chromosomes]] in the [[Nucleus\|nucleus]] during [[Interphase\|interphase]]. First developed by '''''[[Carl Rabl\|Carl Rabl]]''''' (1853-1917) in his paper '''''‘Über zelltheilung, 1885’''''',''‘Rabl orientation’ ''was confirmed later in 1982 by '''C. Cremer''' (1944-) and '''T. Cremer''' (1945-) using 'premature chromosome condensation and laser-UV-microbeam experiments' using 'Chinese hamster cells.'<ref>Cremer, T., Cremer, C., Baumann, H., Luedtke, E.K., Sperling, K., Teuber, V., Zorn, C., 1982, Rabl's model of the interphase chromosome arrangement tested in Chinese hamster cells by premature chromosome condensation and laser-UV-microbeam experiments., Human Genetics, 60(1), pp46-56. Available at: fckLRhttp://link.springer.com/article/10.1007/BF00281263</ref> Recent technological advances such as '''''‘[[FISH\|Fish]]’<ref>Available explanation at: http://www.genome.gov/10000206</ref>''''' has shown all eukaryotic [[Organism\|organisms]] territories are typically 1-2 µm in diameter and irregularly shaped with sub-domains made of individual chromosome arms.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> As well as this, chromatin folding into 'fractal globule' shapes allows distinction between chromosome territory and easy access for replication molecules plus easy unfolding for specific genes.<ref>p235, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones&amp;amp;amp;Bartlett Learning</ref> Gene dense chromosomes also tends to occupy regions near the centre of the nucleus whereas less gene dense chromosomes occupies regions near the peripheral of the nucleus <ref>p236-237, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones&amp;amp;amp;Bartlett Learning</ref>. Neighbouring chromosomes can interact with each other and due to this interaction chromosomes are rendered immobile.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> However, it has become aware that chromosome arrangement in a cell is dependent on cell type/organism/tissue/if diseased and thus we are still unable to predict position.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref><br>

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	=== References ===		=== References ===

	<references />		<references />

140183078 at 15:32, 25 November 2014

2014-11-25T15:32:11Z

← Older revision		Revision as of 15:32, 25 November 2014
Line 1:		Line 1:
	Chromosome territories are specific regions occupied by [[Chromosomes\|chromosomes]] in the [[Nucleus\|nucleus]] during [[Interphase\|interphase]]. First developed by '''''Carl Rabl''''' (1853-1917) in his paper '''''‘Über zelltheilung, 1885’''''',''‘Rabl orientation’ ''was confirmed later in 1982 by '''C. Cremer''' (1944-) and '''T. Cremer''' (1945-) using 'premature chromosome condensation and laser-UV-microbeam experiments' using 'Chinese hamster cells.'<ref>Cremer, T., Cremer, C., Baumann, H., Luedtke, E.K., Sperling, K., Teuber, V., Zorn, C., 1982, Rabl's model of the interphase chromosome arrangement tested in Chinese hamster cells by premature chromosome condensation and laser-UV-microbeam experiments., Human Genetics, 60(1), pp46-56. Available at: fckLRhttp://link.springer.com/article/10.1007/BF00281263</ref> Recent technological advances such as '''''‘Fish’<ref>Available explanation at: http://www.genome.gov/10000206</ref>''''' has shown all eukaryotic organisms territories are typically 1-2µm in diameter and irregularly shaped with sub-domains made of individual chromosome arms.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> As well as this, chromatin folding into 'fractal globule' shapes allows distinction between chromosome territory and easy access for replication molecules plus easy unfolding for specific genes.<ref>p235, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones&amp;Bartlett Learning</ref> Gene dense chromosomes also tends to occupy regions near the centre of the nucleus whereas less gene dense chromosomes occupies regions near the peripheral of the nucleus.<ref>p236-237, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones&amp;Bartlett Learning</ref> Neighbouring chromosomes can interact with each other and due to this interaction chromosomes are rendered immobile.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> However, it has become aware that chromosome arrangement in a cell is dependent on cell type/organism/tissue/if diseased and thus we are still unable to predict position.		Chromosome territories are specific regions occupied by [[Chromosomes\|chromosomes]] in the [[Nucleus\|nucleus]] during [[Interphase\|interphase]]. First developed by '''''Carl Rabl''''' (1853-1917) in his paper '''''‘Über zelltheilung, 1885’''''',''‘Rabl orientation’ ''was confirmed later in 1982 by '''C. Cremer''' (1944-) and '''T. Cremer''' (1945-) using 'premature chromosome condensation and laser-UV-microbeam experiments' using 'Chinese hamster cells.'<ref>Cremer, T., Cremer, C., Baumann, H., Luedtke, E.K., Sperling, K., Teuber, V., Zorn, C., 1982, Rabl's model of the interphase chromosome arrangement tested in Chinese hamster cells by premature chromosome condensation and laser-UV-microbeam experiments., Human Genetics, 60(1), pp46-56. Available at: fckLRhttp://link.springer.com/article/10.1007/BF00281263</ref> Recent technological advances such as '''''‘Fish’<ref>Available explanation at: http://www.genome.gov/10000206</ref>''''' has shown all eukaryotic organisms territories are typically 1-2µm in diameter and irregularly shaped with sub-domains made of individual chromosome arms.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> As well as this, chromatin folding into 'fractal globule' shapes allows distinction between chromosome territory and easy access for replication molecules plus easy unfolding for specific genes.<ref>p235, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones&amp;amp;Bartlett Learning</ref> Gene dense chromosomes also tends to occupy regions near the centre of the nucleus whereas less gene dense chromosomes occupies regions near the peripheral of the nucleus.<ref>p236-237, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones&amp;amp;Bartlett Learning</ref> Neighbouring chromosomes can interact with each other and due to this interaction chromosomes are rendered immobile.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> However, it has become aware that chromosome arrangement in a cell is dependent on cell type/organism/tissue/if diseased and thus we are still unable to predict position.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref>

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140183078 at 15:29, 25 November 2014

2014-11-25T15:29:56Z

← Older revision		Revision as of 15:29, 25 November 2014
Line 1:		Line 1:
	Chromosome territories are specific regions occupied by [[Chromosomes\|chromosomes]] in the [[Nucleus\|nucleus]] during [[Interphase\|interphase]]. First developed by '''''Carl Rabl''''' (1853-1917) in his paper '''''‘Über zelltheilung, 1885’''''',''‘Rabl orientation’ ''was confirmed later in 1982 by '''C. Cremer''' (1944-) and '''T. Cremer''' (1945-) using premature chromosome condensation and laser-UV-microbeam experiments on Chinese hamster cells.<ref>Cremer, T., Cremer, C., Baumann, H., Luedtke, E.K., Sperling, K., Teuber, V., Zorn, C., 1982, Rabl's model of the interphase chromosome arrangement tested in Chinese hamster cells by premature chromosome condensation and laser-UV-microbeam experiments., Human Genetics, 60(1), pp46-56. Available at:		Chromosome territories are specific regions occupied by [[Chromosomes\|chromosomes]] in the [[Nucleus\|nucleus]] during [[Interphase\|interphase]]. First developed by '''''Carl Rabl''''' (1853-1917) in his paper '''''‘Über zelltheilung, 1885’''''',''‘Rabl orientation’ ''was confirmed later in 1982 by '''C. Cremer''' (1944-) and '''T. Cremer''' (1945-) using 'premature chromosome condensation and laser-UV-microbeam experiments' using 'Chinese hamster cells.'<ref>Cremer, T., Cremer, C., Baumann, H., Luedtke, E.K., Sperling, K., Teuber, V., Zorn, C., 1982, Rabl's model of the interphase chromosome arrangement tested in Chinese hamster cells by premature chromosome condensation and laser-UV-microbeam experiments., Human Genetics, 60(1), pp46-56. Available at: fckLRhttp://link.springer.com/article/10.1007/BF00281263</ref> Recent technological advances such as '''''‘Fish’<ref>Available explanation at: http://www.genome.gov/10000206</ref>''''' has shown all eukaryotic organisms territories are typically 1-2µm in diameter and irregularly shaped with sub-domains made of individual chromosome arms.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> As well as this, chromatin folding into 'fractal globule' shapes allows distinction between chromosome territory and easy access for replication molecules plus easy unfolding for specific genes.<ref>p235, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones&amp;Bartlett Learning</ref> Gene dense chromosomes also tends to occupy regions near the centre of the nucleus whereas less gene dense chromosomes occupies regions near the peripheral of the nucleus.<ref>p236-237, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones&amp;Bartlett Learning</ref> Neighbouring chromosomes can interact with each other and due to this interaction chromosomes are rendered immobile.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> However, it has become aware that chromosome arrangement in a cell is dependent on cell type/organism/tissue/if diseased and thus we are still unable to predict position.
	~~http~~://link.springer.com/article/10.1007/BF00281263</ref> Recent technological advances such as '''''‘Fish’<ref>Available explanation at: http://www.genome.gov/10000206</ref>''''' has shown all eukaryotic organisms territories are typically 1-2µm in diameter irregularly shaped with sub-domains made of individual chromosome arms.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> As well as this, chromatin folding into fractal globule shapes allows distinction between chromosome territory ~~distinction~~ and easy access for replication molecules ~~and~~ easy unfolding for specific genes.<ref>p235, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones&Bartlett Learning</ref> Gene dense chromosomes also tends to occupy regions near the centre of the nucleus whereas less gene dense chromosomes occupies regions near the peripheral of the nucleus.<ref>p236-237, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones&Bartlett Learning</ref> Neighbouring chromosomes can interact with each other and due to this interaction chromosomes are rendered immobile.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> However, it has become aware that chromosome arrangement in a cell is dependent on cell type/organism/tissue/if diseased and thus we are still unable to predict position.

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			=== References ===
	=== References ===

	<references />		<references />

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Chromosome territories are specific regions occupied by [[Chromosomes|chromosomes]] in the [[Nucleus|nucleus]] during [[Interphase|interphase]]. First developed by '''''Carl Rabl''''' (1853-1917) in his paper '''''‘Über zelltheilung, 1885’''''',''‘Rabl orientation’ ''was confirmed later in 1982 by '''C. Cremer''' (1944-) and '''T. Cremer''' (1945-) using premature chromosome condensation and laser-UV-microbeam experiments on Chinese hamster cells.<ref>Cremer, T., Cremer, C., Baumann, H., Luedtke, E.K., Sperling, K., Teuber, V., Zorn, C., 1982, Rabl's model of the interphase chromosome arrangement tested in Chinese hamster cells by premature chromosome condensation and laser-UV-microbeam experiments., Human Genetics, 60(1), pp46-56. Available at:
http://link.springer.com/article/10.1007/BF00281263</ref> Recent technological advances such as '''''‘Fish’<ref>Available explanation at: http://www.genome.gov/10000206</ref>''''' has shown all eukaryotic organisms territories are typically 1-2µm in diameter irregularly shaped with sub-domains made of individual chromosome arms.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> As well as this, chromatin folding into fractal globule shapes allows distinction between chromosome territory distinction and easy access for replication molecules and easy unfolding for specific genes.<ref>p235, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones&Bartlett Learning</ref> Gene dense chromosomes also tends to occupy regions near the centre of the nucleus whereas less gene dense chromosomes occupies regions near the peripheral of the nucleus.<ref>p236-237, Hartl, D.L., Ruvolo, M., et al. 2012, Genetics: Analysis of Genes and Genomes, 8th ed., Jones&Bartlett Learning</ref> Neighbouring chromosomes can interact with each other and due to this interaction chromosomes are rendered immobile.<ref>Misteli, T., 2008, Chromosome territories: The arrangement of chromosomes in the nucleus., Nature Education 1(1):167. Available at: http://www.nature.com/scitable/topicpage/chromosome-territories-the-arrangement-of-chromosomes-in-3025</ref> However, it has become aware that chromosome arrangement in a cell is dependent on cell type/organism/tissue/if diseased and thus we are still unable to predict position.

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