Diacylglycerol - Revision history

Nnjm2 at 16:18, 19 November 2010

2010-11-19T16:18:41Z

← Older revision		Revision as of 16:18, 19 November 2010
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	Diacylglycerol (DAG) is molecule which is bound to the inner layer of the phoslipid bilayer in eukaryotic cells by two transmembrane fatty acid tails. DAG is activated when the [[Inositol-Phospholipid signalling pathway\|IP (Inositol-Phospholipid) signalling pathway is]] activated by a [[GPCR\|GPCR (G Protein Coupled Recptor) binding]]. The PI pathway activates [[Phospholipase C\|PLC-β (phospholipase C)]] which catalyses the reaction whereby [[Phosphatidylinositol 4,5-bisphosphate\|PIP<sub>2</sub> (phosphotitylinositol-4,5-bisphosphate)]] is cleaved to form the free molecule [[Inositol 1,4,5 trisphosphate\|IP<sub>3</sub> (Inositol-1,4,5-trisphosphate)]] and DAG. From this DAG is then able to interact further in the cell signalling pathway by activating [[Protein kinase C\|PKC (Ca2+ dependent Protein Kinase]]), which is a kinase involved in an intercellular phosphorylation cascade.		Diacylglycerol (DAG) is molecule which is bound to the inner layer of the phoslipid bilayer in eukaryotic cells by two transmembrane fatty acid tails. DAG is activated when the [[Inositol-Phospholipid signalling pathway\|IP (Inositol-Phospholipid) signalling pathway is]] activated by a [[GPCR\|GPCR (G Protein Coupled Recptor) binding]]. The PI pathway activates [[Phospholipase C\|PLC-β (phospholipase C)]] which catalyses the reaction whereby [[Phosphatidylinositol 4,5-bisphosphate\|PIP<sub>2</sub> (phosphotitylinositol-4,5-bisphosphate)]] is cleaved to form the free [[Molecule\|molecule]] [[Inositol 1,4,5 trisphosphate\|IP<sub>3</sub> (Inositol-1,4,5-trisphosphate)]] and DAG. From this DAG is then able to interact further in the cell signalling pathway by activating [[Protein kinase C\|PKC (Ca2+ dependent Protein Kinase]]), which is a [[Kinase\|kinase]] involved in an intercellular [[Phosphorylation\|phosphorylation]] cascade <ref>Molecular biology of the cell / Bruce Alberts et al,5th ed,New York : Garland Science, c2008.</ref>.<br>

	~~<br>~~		=== References: ===

	~~References:~~		<references /><br><br>

	~~Molecular biology of the cell~~ / ~~Bruce Alberts et al,5th ed,New York : Garland Science, c2008.~~<br><br>

093776750 at 12:48, 19 November 2010

2010-11-19T12:48:16Z

← Older revision		Revision as of 12:48, 19 November 2010
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	Diacylglycerol (DAG) is molecule which is bound to the inner layer of the phoslipid bilayer in eukaryotic cells by two transmembrane fatty acid tails. DAG is activated when the [[Inositol-Phospholipid signalling pathway\|IP (Inositol-Phospholipid) signalling pathway is]] activated by a [[GPCR\|GPCR (G Protein Coupled Recptor) binding]]. The PI pathway activates [[Phospholipase C\|PLC-β (phospholipase C)]] which catalyses the reaction whereby [[Phosphatidylinositol 4,5-bisphosphate\|PIP<sub>2</sub> (phosphotitylinositol-4,5-bisphosphate)]] is cleaved to form the free molecule [[Inositol 1,4,5 trisphosphate\|IP<sub>3</sub> (Inositol-1,4,5-trisphosphate)]] and DAG. From this DAG is then able to interact further in the cell signalling pathway by activating [[Protein kinase C\|PKC (Ca2+ dependent Protein Kinase]]), which is a kinase involved in an intercellular phosphorylation cascade.		Diacylglycerol (DAG) is molecule which is bound to the inner layer of the phoslipid bilayer in eukaryotic cells by two transmembrane fatty acid tails. DAG is activated when the [[Inositol-Phospholipid signalling pathway\|IP (Inositol-Phospholipid) signalling pathway is]] activated by a [[GPCR\|GPCR (G Protein Coupled Recptor) binding]]. The PI pathway activates [[Phospholipase C\|PLC-β (phospholipase C)]] which catalyses the reaction whereby [[Phosphatidylinositol 4,5-bisphosphate\|PIP<sub>2</sub> (phosphotitylinositol-4,5-bisphosphate)]] is cleaved to form the free molecule [[Inositol 1,4,5 trisphosphate\|IP<sub>3</sub> (Inositol-1,4,5-trisphosphate)]] and DAG. From this DAG is then able to interact further in the cell signalling pathway by activating [[Protein kinase C\|PKC (Ca2+ dependent Protein Kinase]]), which is a kinase involved in an intercellular phosphorylation cascade.

			<br>

			References:

	~~<references />~~		Molecular biology of the cell / Bruce Alberts et al,5th ed,New York : Garland Science, c2008.<br><br>

	Molecular biology of the cell / Bruce Alberts et al,5th ed,New York : Garland Science, c2008.<br><br>

093776750 at 12:47, 19 November 2010

2010-11-19T12:47:50Z

← Older revision		Revision as of 12:47, 19 November 2010
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	Diacylglycerol (DAG) is molecule which is bound to the inner layer of the phoslipid bilayer in eukaryotic cells by two transmembrane fatty acid tails. DAG is activated when the [[Inositol-Phospholipid signalling pathway\|IP (Inositol-Phospholipid) signalling pathway ]]is activated by a [[GPCR\|GPCR (G Protein Coupled Recptor) ]]~~binding~~. The PI pathway activates [[~~Phospholipase_C~~\|PLC-β (phospholipase C)]] which catalyses the reaction whereby [[~~Phosphatidylinositol_4~~,5-bisphosphate\|PIP<sub>2</sub> (phosphotitylinositol-4,5-bisphosphate)]] is cleaved to form the free molecule [[~~Inositol_1~~,4,~~5_trisphosphate~~\|IP<sub>3</sub> (Inositol-1,4,5-trisphosphate)]] and DAG. From this DAG is then able to interact further in the cell signalling pathway by activating [[Protein kinase C\|PKC (Ca2+ dependent Protein Kinase]]), which is a kinase involved in an intercellular phosphorylation cascade.		Diacylglycerol (DAG) is molecule which is bound to the inner layer of the phoslipid bilayer in eukaryotic cells by two transmembrane fatty acid tails. DAG is activated when the [[Inositol-Phospholipid signalling pathway\|IP (Inositol-Phospholipid) signalling pathway is]] activated by a [[GPCR\|GPCR (G Protein Coupled Recptor) binding]]. The PI pathway activates [[Phospholipase C\|PLC-β (phospholipase C)]] which catalyses the reaction whereby [[Phosphatidylinositol 4,5-bisphosphate\|PIP<sub>2</sub> (phosphotitylinositol-4,5-bisphosphate)]] is cleaved to form the free molecule [[Inositol 1,4,5 trisphosphate\|IP<sub>3</sub> (Inositol-1,4,5-trisphosphate)]] and DAG. From this DAG is then able to interact further in the cell signalling pathway by activating [[Protein kinase C\|PKC (Ca2+ dependent Protein Kinase]]), which is a kinase involved in an intercellular phosphorylation cascade.



			<references />

			Molecular biology of the cell / Bruce Alberts et al,5th ed,New York : Garland Science, c2008.<br><br>

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2010-11-19T12:39:07Z

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Diacylglycerol (DAG) is molecule which is bound to the inner layer of the phoslipid bilayer in eukaryotic cells by two transmembrane fatty acid tails. DAG is activated when the [[Inositol-Phospholipid signalling pathway|IP (Inositol-Phospholipid) signalling pathway ]]is activated by a [[GPCR|GPCR (G Protein Coupled Recptor) ]]binding. The PI pathway activates [[Phospholipase_C|PLC-β (phospholipase C)]] which catalyses the reaction whereby [[Phosphatidylinositol_4,5-bisphosphate|PIP<sub>2</sub> (phosphotitylinositol-4,5-bisphosphate)]] is cleaved to form the free molecule [[Inositol_1,4,5_trisphosphate|IP<sub>3</sub> (Inositol-1,4,5-trisphosphate)]] and DAG. From this DAG is then able to interact further in the cell signalling pathway by activating [[Protein kinase C|PKC (Ca2+ dependent Protein Kinase]]), which is a kinase involved in an intercellular phosphorylation cascade.