Dystrophin - Revision history

Nnjm2 at 14:10, 28 October 2015

2015-10-28T14:10:23Z

← Older revision		Revision as of 14:10, 28 October 2015
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	Dystrophin is a very large protein, in fact the gene that encodes it, also called dystophin, is the greatest in size within the human body [http://~~ghr~~.~~nlm~~.~~nih.gov~~/~~condition~~/~~duchenne-and-becker-muscular-dystrophy~~]. The protein plays an important role in muscle cohesion both in myogenic and skeletal muscle. It does so by forming a group with other proteins, otherwise known as a protein complex, which is involved in connecting the [cytoskeleton] of the muscle cells to one another. This aids the muscles' strength right down to individual muscle fibres and allows for contraction and relaxation of muscles without such movement would not be possible [http://~~ghr~~.~~nlm.nih~~.~~gov~~/~~condition~~/~~duchenne-and-becker-muscular-dystrophy~~] .		Dystrophin is a very large [[Protein\|protein]], in fact the [[Gene\|gene]] that encodes it, also called dystophin, is the greatest in size within the human body <ref>[Online Mendelian Inheritance in Man (1966-2015) "MUSCULAR DYSTROPHY, DUCHENNE TYPE; DMD" Available at:http://omim.org/entry/310200?search=duchenne%20muscular%20dystrophy&amp;highlight=duchenne%20dystrophy%20muscular. Last accessed 22/10/2015]</ref>. The protein plays an important role in [[Muscle\|muscle]] cohesion both in myogenic and skeletal muscle. It does so by forming a group with other proteins, otherwise known as a protein complex, which is involved in connecting the [[Cytoskeleton\|cytoskeleton]] of the muscle cells to one another. This aids the muscles' strength right down to individual muscle fibres and allows for contraction and relaxation of muscles without such movement would not be possible <ref>[Online Mendelian Inheritance in Man (1966-2015) "MUSCULAR DYSTROPHY, DUCHENNE TYPE; DMD" Available at:http://omim.org/entry/310200?search=duchenne%20muscular%20dystrophy&amp;highlight=duchenne%20dystrophy%20muscular. Last accessed 22/10/2015]</ref>.

			=== Diseases associated with abnormal dystrophin ===

			*[[Duchenne muscular Dystrophy\|Duchenne muscular Dystrophy]] (DMD) - this phenotype can be mapped to Xp21.2-p21.1 on the [[genome\|genome]]. DMD can affect many regions of the body including [[Muscles]] located within the [[Heart]], eyes and nervous system. However it must be added that some of these phenotypes may as a result of [[Pleiotropy]] and not as a direct result of the condition<ref>[Online Mendelian Inheritance in Man (1966-2015) "MUSCULAR DYSTROPHY, DUCHENNE TYPE; DMD" Available at:http://omim.org/entry/310200?search=duchenne%20muscular%20dystrophy&amp;highlight=duchenne%20dystrophy%20muscular. Last accessed 22/10/2015]</ref>.
			*[[Becker muscular dystrophy\|Becker muscular dystrophy]]
			*DMD-associated dilated cardiomyopathy<br>

	== ~~[[Diseases associated with abnormal dystrophin]]~~ ==		=== References ===
	- Duchenne muscular Dystrophy (DMD) - this phenotype can be mapped to Xp21.2-p21.1 on the genome. DMD can affect many regions of the body including [[muscles]] located within the [[heart]], eyes and nervous system. However it must be added that some of these phenotypes may as a result of [[pleiotropy]] and not as a direct result of the condition[http://omim.org/entry/310200?search=~~duchenne%20muscular%20dystrophy&highlight~~=~~duchenne%20dystrophy%20muscular].~~

	~~- Becker muscular dystrophy~~		<references /><br>

	~~- DMD-associated dilated cardiomyopathy~~


	~~== References ==~~
	~~[3] [Online Mendelian Inheritance in Man (1966-2015) "MUSCULAR DYSTROPHY, DUCHENNE TYPE; DMD" Available at:http:~~/~~/omim.org/entry/310200?search=duchenne%20muscular%20dystrophy&highlight=duchenne%20dystrophy%20muscular. Last accessed 22/10/2015]~~

140256497 at 15:07, 22 October 2015

2015-10-22T15:07:37Z

← Older revision		Revision as of 15:07, 22 October 2015
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	== References ==		== References ==
	[3] [Online Mendelian Inheritance in Man (1966-2015) "MUSCULAR DYSTROPHY, DUCHENNE TYPE; DMD" Available at: [http://omim.org/entry/310200?search=duchenne%20muscular%20dystrophy&highlight=duchenne%20dystrophy%20muscular] Last accessed 22/10/2015]		[3] [Online Mendelian Inheritance in Man (1966-2015) "MUSCULAR DYSTROPHY, DUCHENNE TYPE; DMD" Available at:http://omim.org/entry/310200?search=duchenne%20muscular%20dystrophy&highlight=duchenne%20dystrophy%20muscular. Last accessed 22/10/2015]

140256497 at 15:06, 22 October 2015

2015-10-22T15:06:54Z

← Older revision		Revision as of 15:06, 22 October 2015
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	== [[Diseases associated with abnormal ~~dystophin~~]] ==		== [[Diseases associated with abnormal dystrophin]] ==
	- Duchenne muscular Dystrophy		- Duchenne muscular Dystrophy (DMD) - this phenotype can be mapped to Xp21.2-p21.1 on the genome. DMD can affect many regions of the body including [[muscles]] located within the [[heart]], eyes and nervous system. However it must be added that some of these phenotypes may as a result of [[pleiotropy]] and not as a direct result of the condition[http://omim.org/entry/310200?search=duchenne%20muscular%20dystrophy&highlight=duchenne%20dystrophy%20muscular].

	- Becker muscular dystrophy		- Becker muscular dystrophy

	- DMD-associated dilated cardiomyopathy		- DMD-associated dilated cardiomyopathy


			== References ==
			[3] [Online Mendelian Inheritance in Man (1966-2015) "MUSCULAR DYSTROPHY, DUCHENNE TYPE; DMD" Available at: [http://omim.org/entry/310200?search=duchenne%20muscular%20dystrophy&highlight=duchenne%20dystrophy%20muscular] Last accessed 22/10/2015]

140255478 at 14:41, 22 October 2015

2015-10-22T14:41:22Z

← Older revision		Revision as of 14:41, 22 October 2015
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	Dystrophin is a very large protein, in fact the gene that encodes it, also called dystophin, is the greatest in size within the human body. The protein plays an important role in muscle cohesion both in myogenic and skeletal muscle. It does so by forming a group with other proteins, otherwise known as a protein complex, which is involved in connecting the [cytoskeleton] of the muscle cells to one another. This aids the muscles' strength right down to individual muscle fibres and allows for contraction and relaxation of muscles without such movement would not be possible [http://ghr.nlm.nih.gov/condition/duchenne-and-becker-muscular-dystrophy].		Dystrophin is a very large protein, in fact the gene that encodes it, also called dystophin, is the greatest in size within the human body [http://ghr.nlm.nih.gov/condition/duchenne-and-becker-muscular-dystrophy]. The protein plays an important role in muscle cohesion both in myogenic and skeletal muscle. It does so by forming a group with other proteins, otherwise known as a protein complex, which is involved in connecting the [cytoskeleton] of the muscle cells to one another. This aids the muscles' strength right down to individual muscle fibres and allows for contraction and relaxation of muscles without such movement would not be possible [http://ghr.nlm.nih.gov/condition/duchenne-and-becker-muscular-dystrophy] .

140255478: Created page with "Dystrophin is a very large protein, in fact the gene that encodes it, also called dystophin, is the greatest in size within the human body. The protein plays an important role in..."

2015-10-22T14:39:46Z

Created page with "Dystrophin is a very large protein, in fact the gene that encodes it, also called dystophin, is the greatest in size within the human body. The protein plays an important role in..."

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Dystrophin is a very large protein, in fact the gene that encodes it, also called dystophin, is the greatest in size within the human body. The protein plays an important role in muscle cohesion both in myogenic and skeletal muscle. It does so by forming a group with other proteins, otherwise known as a protein complex, which is involved in connecting the [cytoskeleton] of the muscle cells to one another. This aids the muscles' strength right down to individual muscle fibres and allows for contraction and relaxation of muscles without such movement would not be possible [http://ghr.nlm.nih.gov/condition/duchenne-and-becker-muscular-dystrophy].

== [[Diseases associated with abnormal dystophin]] ==
- Duchenne muscular Dystrophy

- Becker muscular dystrophy

- DMD-associated dilated cardiomyopathy