Gamma-Aminobutyric acid - Revision history

Nnjm2: Added the references correctly, that is, I added them as explained in the lecture. Cleaned up the text. Removed some stray code.

2017-11-29T19:30:18Z

Added the references correctly, that is, I added them as explained in the lecture. Cleaned up the text. Removed some stray code.

← Older revision		Revision as of 19:30, 29 November 2017
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	GABA is an inhibitory [[Neurotransmitter\|neurotransmitter]] in [[~~Central_nervous_system~~\|central nervous system]] which is synthesised from [[~~glutamate~~\|glutamate]] in brain cells<ref>http://www.denvernaturopathic.com/news/GABA.html</ref>.		GABA is an inhibitory [[Neurotransmitter\|neurotransmitter]] in [[Central nervous system\|central nervous system]] which is synthesised from [[Glutamate\|glutamate]] in brain cells<ref>http://www.denvernaturopathic.com/news/GABA.html</ref>.

	When GABA binds to its receptors in the [[~~synapse~~\|synapse]], it allows the influx of negatively charged [[~~chloride~~\|chloride]] [[~~ions~~\|ions]] into the [[~~neurone~~\|neurone]] which reduces the neurons excitability<ref>http://thebrain.mcgill.ca/flash/d/d_04/d_04_m/d_04_m_peu/d_04_m_peu.html</ref>~~<br>~~		When GABA binds to its receptors in the [[Synapse\|synapse]], it allows the influx of negatively charged [[Chloride\|chloride]] [[Ions\|ions]] into the [[Neurone\|neurone]] which reduces the neurons excitability<ref>http://thebrain.mcgill.ca/flash/d/d_04/d_04_m/d_04_m_peu/d_04_m_peu.html</ref>.

	GABA is the main inhibitory neurotransmitter in the brain and Glutamate is the main excitatory neurotransmitter. GABA is formed from glutamate by the enzyme~~ ~~glutamic acid decarboxylase<~~sup~~>~~<span style="font-size: 14~~.~~608px~~;~~">3~~</~~span></sup~~>. The two receptors for GABA are GABA<sub>A</sub> and GABA~~<sub></sub>~~<sub>B</sub>, found in the postsynaptic membrane<~~sup~~>~~<span style="font-size: 14~~.~~608px;">4</span>~~</~~sup~~>.~~ <sub></sub>~~GABA~~<sub></sub>~~<sub>A</sub> receptors are fast-acting, ligand-gated channels which, when open, allows Cl<sup>-</sup> ions to enter the cell, this is inhibitory as the movement of these ions into the cell decreases the membrane potential and so is further away from the threshold to trigger an action potential. GABA can be used to treat various disorders, including anxiety disorders, as it can rectify an imbalance in the amount of glutamate (which is excitatory) <~~sup~~>5</~~sup~~>.		GABA is the main inhibitory neurotransmitter in the brain and Glutamate is the main excitatory neurotransmitter. GABA is formed from glutamate by the enzyme glutamic acid decarboxylase<ref>Petroff OA1.GABA and glutamate in the human brain.2002 Dec;8.Department of Neurology, Yale University, New Haven, Connecticut 06520-8018, USA</ref>. The two receptors for GABA are GABA<sub>A</sub> and GABA<sub>B</sub>, found in the postsynaptic membrane<ref>Ion Channels and Disease. Frances M. Ashcroft. Elsevier. 2000</ref>. GABA<sub>A</sub> receptors are fast-acting, ligand-gated channels which, when open, allows Cl<sup>-</sup> ions to enter the cell, this is inhibitory as the movement of these ions into the cell decreases the membrane potential and so is further away from the threshold to trigger an action potential. GABA can be used to treat various disorders, including anxiety disorders, as it can rectify an imbalance in the amount of glutamate (which is excitatory)<ref>Lydiard RB. The role of GABA in anxiety disorders. Medical University of South Carolina, Charleston, USA. https://www.ncbi.nlm.nih.gov/pubmed/12662130</ref>.

	=== References ===		=== References ===

	<references />~~3.Petroff OA1.GABA and glutamate in the human brain.2002 Dec;8.Department of Neurology, Yale University, New Haven, Connecticut 06520-8018, USA~~		<references />

	~~4. Ion Channels and Disease. Frances M. Ashcroft. Elsevier. 2000~~

	~~5.Lydiard RB. The role of GABA in anxiety disorders. Medical University of South Carolina, Charleston, USA. https://www.ncbi.nlm.nih.gov/pubmed/12662130~~

160111606 at 18:24, 29 November 2017

2017-11-29T18:24:55Z

← Older revision		Revision as of 18:24, 29 November 2017
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	When GABA binds to its receptors in the [[synapse\|synapse]], it allows the influx of negatively charged [[chloride\|chloride]] [[ions\|ions]] into the [[neurone\|neurone]] which reduces the neurons excitability<ref>http://thebrain.mcgill.ca/flash/d/d_04/d_04_m/d_04_m_peu/d_04_m_peu.html</ref><br>		When GABA binds to its receptors in the [[synapse\|synapse]], it allows the influx of negatively charged [[chloride\|chloride]] [[ions\|ions]] into the [[neurone\|neurone]] which reduces the neurons excitability<ref>http://thebrain.mcgill.ca/flash/d/d_04/d_04_m/d_04_m_peu/d_04_m_peu.html</ref><br>

	~~===~~ GABA is the main inhibitory neurotransmitter in the brain and Glutamate is the main excitatory neurotransmitter.~~ '~~GABA is formed from glutamate by the enzyme glutamic acid decarboxylase<sup>1</sup>. The two receptors for GABA are GABA<sub>A</sub> and GABA<sub></sub><sub>B</sub>, found in the postsynaptic membrane<sup>2</sup>. <sub></sub>GABA<sub></sub><sub>A</sub> receptors are fast-acting, ligand-gated channels which, when open, allows Cl<sup>-</sup> ions to enter the cell, this is inhibitory as the movement of these ions into the cell decreases the membrane potential and so is further away from the threshold to trigger an action potential. GABA can be used~~ <span style="background-color: initial; font-size: 17.5296px;">~~to treat various disorders, including anxiety disorders as it can rectify an imbalance in the amount of glutamate (which is excitatory)<sup>3</sup>.~~ </span> ===~~		GABA is the main inhibitory neurotransmitter in the brain and Glutamate is the main excitatory neurotransmitter. GABA is formed from glutamate by the enzyme glutamic acid decarboxylase<sup><span style="font-size: 14.608px;">3</span></sup>. The two receptors for GABA are GABA<sub>A</sub> and GABA<sub></sub><sub>B</sub>, found in the postsynaptic membrane<sup><span style="font-size: 14.608px;">4</span></sup>. <sub></sub>GABA<sub></sub><sub>A</sub> receptors are fast-acting, ligand-gated channels which, when open, allows Cl<sup>-</sup> ions to enter the cell, this is inhibitory as the movement of these ions into the cell decreases the membrane potential and so is further away from the threshold to trigger an action potential. GABA can be used to treat various disorders, including anxiety disorders, as it can rectify an imbalance in the amount of glutamate (which is excitatory) <sup>5</sup>.

	=== References ===		=== References ===

160111606 at 18:22, 29 November 2017

2017-11-29T18:22:47Z

← Older revision		Revision as of 18:22, 29 November 2017
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	=== References ===		=== References ===

	<references />~~(1)~~Petroff OA1.GABA and glutamate in the human brain.2002 Dec;8.Department of Neurology, Yale University, New Haven, Connecticut 06520-8018, USA		<references />3.Petroff OA1.GABA and glutamate in the human brain.2002 Dec;8.Department of Neurology, Yale University, New Haven, Connecticut 06520-8018, USA

	2. Ion Channels and Disease. Frances M. Ashcroft. Elsevier. 2000		4. Ion Channels and Disease. Frances M. Ashcroft. Elsevier. 2000

	3.Lydiard RB. The role of GABA in anxiety disorders. Medical University of South Carolina, Charleston, USA. https://www.ncbi.nlm.nih.gov/pubmed/12662130		5.Lydiard RB. The role of GABA in anxiety disorders. Medical University of South Carolina, Charleston, USA. https://www.ncbi.nlm.nih.gov/pubmed/12662130

160111606 at 18:21, 29 November 2017

2017-11-29T18:21:24Z

← Older revision		Revision as of 18:21, 29 November 2017
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	When GABA binds to its receptors in the [[synapse\|synapse]], it allows the influx of negatively charged [[chloride\|chloride]] [[ions\|ions]] into the [[neurone\|neurone]] which reduces the neurons excitability<ref>http://thebrain.mcgill.ca/flash/d/d_04/d_04_m/d_04_m_peu/d_04_m_peu.html</ref><br>		When GABA binds to its receptors in the [[synapse\|synapse]], it allows the influx of negatively charged [[chloride\|chloride]] [[ions\|ions]] into the [[neurone\|neurone]] which reduces the neurons excitability<ref>http://thebrain.mcgill.ca/flash/d/d_04/d_04_m/d_04_m_peu/d_04_m_peu.html</ref><br>

			=== GABA is the main inhibitory neurotransmitter in the brain and Glutamate is the main excitatory neurotransmitter. 'GABA is formed from glutamate by the enzyme glutamic acid decarboxylase<sup>1</sup>. The two receptors for GABA are GABA<sub>A</sub> and GABA<sub></sub><sub>B</sub>, found in the postsynaptic membrane<sup>2</sup>. <sub></sub>GABA<sub></sub><sub>A</sub> receptors are fast-acting, ligand-gated channels which, when open, allows Cl<sup>-</sup> ions to enter the cell, this is inhibitory as the movement of these ions into the cell decreases the membrane potential and so is further away from the threshold to trigger an action potential. GABA can be used <span style="background-color: initial; font-size: 17.5296px;">to treat various disorders, including anxiety disorders as it can rectify an imbalance in the amount of glutamate (which is excitatory)<sup>3</sup>. </span> ===

	=== References ===		=== References ===

	<references />		<references />(1)Petroff OA1.GABA and glutamate in the human brain.2002 Dec;8.Department of Neurology, Yale University, New Haven, Connecticut 06520-8018, USA

			2. Ion Channels and Disease. Frances M. Ashcroft. Elsevier. 2000

			3.Lydiard RB. The role of GABA in anxiety disorders. Medical University of South Carolina, Charleston, USA. https://www.ncbi.nlm.nih.gov/pubmed/12662130

Nnjm2: Cleaned up page, and added some links.

2016-12-04T14:56:36Z

Cleaned up page, and added some links.

← Older revision		Revision as of 14:56, 4 December 2016
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	~~ ~~GABA is an inhibitory neurotransmitter in central nervous system which is synthesised from glutamate in brain cells<ref>http://www.denvernaturopathic.com/news/GABA.html</ref>.		GABA is an inhibitory [[Neurotransmitter\|neurotransmitter]] in [[Central_nervous_system\|central nervous system]] which is synthesised from [[glutamate\|glutamate]] in brain cells<ref>http://www.denvernaturopathic.com/news/GABA.html</ref>.

	When GABA binds to its receptors in the synapse, it allows the influx of negatively charged chloride ions into the neurone which reduces the neurons excitability<ref>http://thebrain.mcgill.ca/flash/d/d_04/d_04_m/d_04_m_peu/d_04_m_peu.html</ref><br>		When GABA binds to its receptors in the [[synapse\|synapse]], it allows the influx of negatively charged [[chloride\|chloride]] [[ions\|ions]] into the [[neurone\|neurone]] which reduces the neurons excitability<ref>http://thebrain.mcgill.ca/flash/d/d_04/d_04_m/d_04_m_peu/d_04_m_peu.html</ref><br>

	=== References ===		=== References ===

	<references />		<references />

160330023: Created page with " GABA is an inhibitory neurotransmitter in central nervous system which is synthesised from glutamate in brain cellshttp://www.denvernaturopathic.com/news/GABA.html
2016-12-04T13:04:18Z

Created page with " GABA is an inhibitory neurotransmitter in central nervous system which is synthesised from glutamate in brain cells<ref>http://www.denvernaturopathic.com/news/GABA.html</re..."

New page
 GABA is an inhibitory neurotransmitter in central nervous system which is synthesised from glutamate in brain cells<ref>http://www.denvernaturopathic.com/news/GABA.html</ref>.

When GABA binds to its receptors in the synapse, it allows the influx of negatively charged chloride ions into the neurone which reduces the neurons excitability<ref>http://thebrain.mcgill.ca/flash/d/d_04/d_04_m/d_04_m_peu/d_04_m_peu.html</ref><br>

=== References ===

<references />