https://teaching.ncl.ac.uk/bms/wiki//index.php?action=history&feed=atom&title=HDAC
HDAC - Revision history
2026-04-10T15:02:18Z
Revision history for this page on the wiki
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https://teaching.ncl.ac.uk/bms/wiki//index.php?title=HDAC&diff=20850&oldid=prev
Nnjm2 at 17:42, 18 October 2018
2018-10-18T17:42:14Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:42, 18 October 2018</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">&nbsp;</del>HDACs are a group of [<del style="font-weight: bold; text-decoration: none;">https://teaching.ncl.ac.uk/bms/wiki/index.php/Enzyme </del>enzymes ]which serve to [<del style="font-weight: bold; text-decoration: none;">https://teaching.ncl.ac.uk/bms/wiki/index.php/Catalysis </del>catalyse] the deacetylation of [<del style="font-weight: bold; text-decoration: none;">https://teaching.ncl.ac.uk/bms/wiki/index.php/Lysine </del>lysine] residues primarily in [<del style="font-weight: bold; text-decoration: none;">https://teaching.ncl.ac.uk/bms/wiki/index.php/Histones </del>histone] proteins. Histone deacetylases serve to reverse the action of [<del style="font-weight: bold; text-decoration: none;">https://teaching.ncl.ac.uk/bms/wiki/index.php/Histone_Acetyl_Transferases </del>histone acetylases] (HATs). As [<del style="font-weight: bold; text-decoration: none;">https://teaching.ncl.ac.uk/bms/wiki/index.php/Acetylation </del>acetylation] serves to increase the expression of [<del style="font-weight: bold; text-decoration: none;">https://teaching.ncl.ac.uk/bms/wiki/index.php/Gene </del>genes] by recruitment of bromodomains, deacetylation serves to decrease expression, therefore increasing repression<ref>Seto E, Yoshida M. Erasers of Histone Acetylation: The Histone Deacetylase Enzymes. Cold Spring Harbor Perspectives in Biology. 2014;6(4):a018713. doi:10.1101/cshperspect.a018713.</ref>.&nbsp; </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>HDACs are a group of [<ins style="font-weight: bold; text-decoration: none;">[Enzymes|</ins>enzymes<ins style="font-weight: bold; text-decoration: none;">]</ins>] which serve to [<ins style="font-weight: bold; text-decoration: none;">[catalyse|</ins>catalyse<ins style="font-weight: bold; text-decoration: none;">]</ins>] the <ins style="font-weight: bold; text-decoration: none;">[[</ins>deacetylation<ins style="font-weight: bold; text-decoration: none;">|deacetylation]] </ins>of [<ins style="font-weight: bold; text-decoration: none;">[lysine|</ins>lysine<ins style="font-weight: bold; text-decoration: none;">]</ins>] residues primarily in [<ins style="font-weight: bold; text-decoration: none;">[histone|</ins>histone]<ins style="font-weight: bold; text-decoration: none;">] [[</ins>proteins<ins style="font-weight: bold; text-decoration: none;">|proteins]]</ins>. <ins style="font-weight: bold; text-decoration: none;">[[</ins>Histone deacetylases<ins style="font-weight: bold; text-decoration: none;">|Histone deacetylases]] </ins>serve to reverse the action of [<ins style="font-weight: bold; text-decoration: none;">[histone acetylases|</ins>histone acetylases<ins style="font-weight: bold; text-decoration: none;">]</ins>] (HATs). As [<ins style="font-weight: bold; text-decoration: none;">[acetylation|</ins>acetylation<ins style="font-weight: bold; text-decoration: none;">]</ins>] serves to increase the expression of [<ins style="font-weight: bold; text-decoration: none;">[genes|</ins>genes<ins style="font-weight: bold; text-decoration: none;">]</ins>] by recruitment of <ins style="font-weight: bold; text-decoration: none;">[[</ins>bromodomains<ins style="font-weight: bold; text-decoration: none;">|bromodomains]]</ins>, <ins style="font-weight: bold; text-decoration: none;">[[deacetylation|</ins>deacetylation<ins style="font-weight: bold; text-decoration: none;">]] </ins>serves to decrease expression, therefore increasing repression<ref>Seto E, Yoshida M. Erasers of Histone Acetylation: The Histone Deacetylase Enzymes. Cold Spring Harbor Perspectives in Biology. 2014;6(4):a018713. doi:10.1101/cshperspect.a018713.</ref>.&nbsp; </div></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>=== <del style="font-weight: bold; text-decoration: none;">'''</del>References<del style="font-weight: bold; text-decoration: none;">''' </del> ===</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>=== References ===</div></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><references /<del style="font-weight: bold; text-decoration: none;">><br</del>></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><references /></div></td></tr>
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Nnjm2
https://teaching.ncl.ac.uk/bms/wiki//index.php?title=HDAC&diff=20799&oldid=prev
170094085: Created page with " HDACs are a group of [https://teaching.ncl.ac.uk/bms/wiki/index.php/Enzyme enzymes ]which serve to [https://teaching.ncl.ac.uk/bms/wiki/index.php/Catalysis catalyse] the de..."
2018-10-18T13:36:15Z
<p>Created page with " HDACs are a group of [https://teaching.ncl.ac.uk/bms/wiki/index.php/Enzyme enzymes ]which serve to [https://teaching.ncl.ac.uk/bms/wiki/index.php/Catalysis catalyse] the de..."</p>
<p><b>New page</b></p><div>&nbsp;HDACs are a group of [https://teaching.ncl.ac.uk/bms/wiki/index.php/Enzyme enzymes ]which serve to [https://teaching.ncl.ac.uk/bms/wiki/index.php/Catalysis catalyse] the deacetylation of [https://teaching.ncl.ac.uk/bms/wiki/index.php/Lysine lysine] residues primarily in [https://teaching.ncl.ac.uk/bms/wiki/index.php/Histones histone] proteins. Histone deacetylases serve to reverse the action of [https://teaching.ncl.ac.uk/bms/wiki/index.php/Histone_Acetyl_Transferases histone acetylases] (HATs). As [https://teaching.ncl.ac.uk/bms/wiki/index.php/Acetylation acetylation] serves to increase the expression of [https://teaching.ncl.ac.uk/bms/wiki/index.php/Gene genes] by recruitment of bromodomains, deacetylation serves to decrease expression, therefore increasing repression<ref>Seto E, Yoshida M. Erasers of Histone Acetylation: The Histone Deacetylase Enzymes. Cold Spring Harbor Perspectives in Biology. 2014;6(4):a018713. doi:10.1101/cshperspect.a018713.</ref>.&nbsp; <br />
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=== '''References''' ===<br />
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170094085