Heamolytic disease of the newborn - Revision history

Nnjm2: Cleaned up the references.

2017-12-05T20:50:37Z

Cleaned up the references.

← Older revision		Revision as of 20:50, 5 December 2017
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	Haemolytic disease of the newborn (''Erythroblastosis fetalis'') is a disease in which [[Rhesus incompatibility\|Rhesus incompatibility]] between a mother and a foetus causes the mother's [[~~immune~~ system\|immune system]] to attack and destroy the foetal [[Red blood cells\|RBCs]]. This results in severe [[Haemolytic anaemia\|haemolytic anaemia]] and the associated issues of intravascular coagulation, damage to the [[Heart\|heart and]] [[Lungs\|lungs]], jaundice and swelling of the[[Liver\|liver and]] spleen in the foetus <ref>Patton, T. (2010)The human body in health and disease (5th ed). Missouri; Mosby Elsevier. Chapter 12, page 355</ref>.		Haemolytic disease of the newborn (''Erythroblastosis fetalis'') is a disease in which [[Rhesus incompatibility\|Rhesus incompatibility]] between a mother and a foetus causes the mother's [[Immune system\|immune system]] to attack and destroy the foetal [[Red blood cells\|RBCs]]. This results in severe [[Haemolytic anaemia\|haemolytic anaemia]] and the associated issues of intravascular coagulation, damage to the [[Heart\|heart and]] [[Lungs\|lungs]], jaundice and swelling of the[[Liver\|liver and]] spleen in the foetus<ref>Patton, T. (2010)The human body in health and disease (5th ed). Missouri; Mosby Elsevier. Chapter 12, page 355</ref>.

	=== Cause ===		=== Cause ===

	Haemolytic disease of the ~~new born~~ occurs, when Rh positive foetal RBCs cross the [[Placenta\|placenta]] and enter the [[Rh negative\|Rh negative]] mother’s ~~blood stream~~. The Rhesus [[Antigens\|antigens]] expressed on the foetal RBCs are recognised as foreign to the maternal immune system and [[IgG\|IgG]] antibodies are raised against them. These maternal anti-Rh IgGs are capable of crossing the placenta and coating the foetal RBCs, enabling [[Phagocytosis\|phagocytosis]] by [[White blood cells\|white blood cells]] <ref>Murphy K. (2012)Janeway's Immunobiology (8th edition)Newyork; Garland Science. Page 729</ref>.		Haemolytic disease of the newborn occurs, when Rh positive foetal RBCs cross the [[Placenta\|placenta]] and enter the [[Rh negative\|Rh negative]] mother’s bloodstream. The Rhesus [[Antigens\|antigens]] expressed on the foetal RBCs are recognised as foreign to the maternal immune system and [[IgG\|IgG]] antibodies are raised against them. These maternal anti-Rh IgGs are capable of crossing the placenta and coating the foetal RBCs, enabling [[Phagocytosis\|phagocytosis]] by [[White blood cells\|white blood cells]]<ref>Murphy K. (2012)Janeway's Immunobiology (8th edition)Newyork; Garland Science. Page 729</ref>.

	=== References ===		=== References ===

	<references />		<references />

170263289 at 18:59, 5 December 2017

2017-12-05T18:59:05Z

← Older revision		Revision as of 18:59, 5 December 2017
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	=== Cause ===		=== Cause ===

	Haemolytic disease of the new born occurs when Rh positive foetal RBCs cross the [[~~placenta~~\|placenta]] and enter the [[Rh negative\|Rh negative]] mother’s blood stream. The Rhesus [[~~antigens~~\|antigens]] expressed on the foetal RBCs are recognised as foreign to the maternal immune system and [[IgG\|IgG]] antibodies are raised against them. These maternal anti-Rh IgGs are capable of crossing the placenta and coating the foetal RBCs, enabling [[Phagocytosis\|phagocytosis]] by [[White blood cells\|white blood cells]] <ref>Murphy K. (2012)Janeway's Immunobiology (8th edition)Newyork; Garland Science. Page 729</ref>.		Haemolytic disease of the new born occurs, when Rh positive foetal RBCs cross the [[Placenta\|placenta]] and enter the [[Rh negative\|Rh negative]] mother’s blood stream. The Rhesus [[Antigens\|antigens]] expressed on the foetal RBCs are recognised as foreign to the maternal immune system and [[IgG\|IgG]] antibodies are raised against them. These maternal anti-Rh IgGs are capable of crossing the placenta and coating the foetal RBCs, enabling [[Phagocytosis\|phagocytosis]] by [[White blood cells\|white blood cells]] <ref>Murphy K. (2012)Janeway's Immunobiology (8th edition)Newyork; Garland Science. Page 729</ref>.

	=== References ===		=== References ===

	<references />		<references />

Nnjm2 at 09:44, 29 October 2017

2017-10-29T09:44:31Z

← Older revision		Revision as of 09:44, 29 October 2017
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	Haemolytic disease of the ~~new born~~ (Erythroblastosis fetalis) is a disease in which Rhesus incompatibility between a mother and a foetus causes the ~~mothers~~ immune system to attack and destroy the foetal [[Red blood cells\|RBCs]]. This results in severe [[~~Haemolytic_anaemia~~\|haemolytic anaemia]] and the associated issues of intravascular coagulation, damage to the [[Heart\|heart and]] [[Lungs\|lungs]], jaundice and swelling of the[[Liver\|liver and]] spleen~~ ~~in the foetus~~ ~~<ref>Patton, T. (2010)The human body in health and disease (5th ed). Missouri; Mosby Elsevier. Chapter 12, page 355</ref>.		Haemolytic disease of the newborn (''Erythroblastosis fetalis'') is a disease in which [[Rhesus incompatibility\|Rhesus incompatibility]] between a mother and a foetus causes the mother's [[immune system\|immune system]] to attack and destroy the foetal [[Red blood cells\|RBCs]]. This results in severe [[Haemolytic anaemia\|haemolytic anaemia]] and the associated issues of intravascular coagulation, damage to the [[Heart\|heart and]] [[Lungs\|lungs]], jaundice and swelling of the[[Liver\|liver and]] spleen in the foetus <ref>Patton, T. (2010)The human body in health and disease (5th ed). Missouri; Mosby Elsevier. Chapter 12, page 355</ref>.

	=== Cause ===		=== Cause ===

	Haemolytic disease of the new born occurs when Rh positive foetal RBCs cross the placenta and enter the Rh negative mother’s blood stream. The Rhesus antigens expressed on the foetal RBCs are recognised as foreign to the maternal immune system and [[IgG\|IgG]] antibodies are raised against them. These maternal anti-Rh IgGs are capable of crossing the placenta and coating the foetal RBCs, enabling [[Phagocytosis\|phagocytosis]] by [[White blood cells\|white blood cells]]~~ ~~<ref>Murphy K. (2012)Janeway's Immunobiology (8th edition)Newyork;Garland ~~Scienece~~. Page 729</ref>.		Haemolytic disease of the new born occurs when Rh positive foetal RBCs cross the [[placenta\|placenta]] and enter the [[Rh negative\|Rh negative]] mother’s blood stream. The Rhesus [[antigens\|antigens]] expressed on the foetal RBCs are recognised as foreign to the maternal immune system and [[IgG\|IgG]] antibodies are raised against them. These maternal anti-Rh IgGs are capable of crossing the placenta and coating the foetal RBCs, enabling [[Phagocytosis\|phagocytosis]] by [[White blood cells\|white blood cells]] <ref>Murphy K. (2012)Janeway's Immunobiology (8th edition)Newyork; Garland Science. Page 729</ref>.

	=== References ===		=== References ===

	<references />		<references />

150609575 at 15:07, 28 October 2017

2017-10-28T15:07:09Z

← Older revision		Revision as of 15:07, 28 October 2017
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	Haemolytic disease of the new born (Erythroblastosis fetalis) is a disease in which Rhesus incompatibility between a mother and a foetus causes the mothers immune system to attack and destroy the foetal [[Red blood cells\|RBCs]]. This results in severe haemolytic anaemia and the associated issues of intravascular coagulation, damage to the [[Heart\|heart and]] [[Lungs\|lungs]], jaundice and swelling of the[[Liver\|liver and]] spleen in the foetus <ref>Patton, T. (2010)The human body in health and disease (5th ed). Missouri; Mosby Elsevier. Chapter 12, page 355</ref>.		Haemolytic disease of the new born (Erythroblastosis fetalis) is a disease in which Rhesus incompatibility between a mother and a foetus causes the mothers immune system to attack and destroy the foetal [[Red blood cells\|RBCs]]. This results in severe [[Haemolytic_anaemia\|haemolytic anaemia]] and the associated issues of intravascular coagulation, damage to the [[Heart\|heart and]] [[Lungs\|lungs]], jaundice and swelling of the[[Liver\|liver and]] spleen in the foetus <ref>Patton, T. (2010)The human body in health and disease (5th ed). Missouri; Mosby Elsevier. Chapter 12, page 355</ref>.

	=== Cause ===		=== Cause ===

	Haemolytic disease of the new born occurs when Rh positive foetal RBCs cross the placenta and enter the Rh negative mother’s blood stream. The Rhesus antigens expressed on the foetal RBCs are recognised as foreign to the maternal immune system and [[IgG\|IgG]] antibodies are raised against them. These maternal anti-Rh IgGs are capable of crossing the placenta and coating the foetal RBCs, enabling [[Phagocytosis\|phagocytosis]] by [[White blood cells\|white blood cells]] <ref>Murphy K. (2012)Janeway's Immunobiology (8th edition)Newyork;Garland Scienece. Page 729</ref>.		Haemolytic disease of the new born occurs when Rh positive foetal RBCs cross the placenta and enter the Rh negative mother’s blood stream. The Rhesus antigens expressed on the foetal RBCs are recognised as foreign to the maternal immune system and [[IgG\|IgG]] antibodies are raised against them. These maternal anti-Rh IgGs are capable of crossing the placenta and coating the foetal RBCs, enabling [[Phagocytosis\|phagocytosis]] by [[White blood cells\|white blood cells]] <ref>Murphy K. (2012)Janeway's Immunobiology (8th edition)Newyork;Garland Scienece. Page 729</ref>.

	=== References ===		=== References ===

	<references />		<references />

Nnjm2 at 02:06, 25 October 2013

2013-10-25T02:06:50Z

← Older revision		Revision as of 02:06, 25 October 2013
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	Haemolytic disease of the new born (Erythroblastosis fetalis) is a disease in which Rhesus incompatibility between a mother and a foetus causes the mothers immune system to attack and destroy the foetal [[Red blood cells\|RBCs]]. This results in severe haemolytic anaemia and the associated issues of intravascular coagulation, damage to the [[Heart\|heart and]] [[Lungs\|lungs]], jaundice and swelling of the[[Liver\|liver and]] spleen in the foetus.<ref>Patton, T. (2010)The human body in health and disease (5th ed). Missouri; Mosby Elsevier. Chapter 12, page 355</ref>		Haemolytic disease of the new born (Erythroblastosis fetalis) is a disease in which Rhesus incompatibility between a mother and a foetus causes the mothers immune system to attack and destroy the foetal [[Red blood cells\|RBCs]]. This results in severe haemolytic anaemia and the associated issues of intravascular coagulation, damage to the [[Heart\|heart and]] [[Lungs\|lungs]], jaundice and swelling of the[[Liver\|liver and]] spleen in the foetus <ref>Patton, T. (2010)The human body in health and disease (5th ed). Missouri; Mosby Elsevier. Chapter 12, page 355</ref>.

	~~<u>~~Cause~~</u>~~		=== Cause ===

	Haemolytic disease of the new born occurs when Rh positive foetal RBCs cross the placenta and enter the Rh negative mother’s blood stream. The Rhesus antigens expressed on the foetal RBCs are recognised as foreign to the maternal immune system and [[IgG\|IgG]] antibodies are raised against them. These maternal anti-Rh IgGs are capable of crossing the placenta and coating the foetal RBCs, enabling [[Phagocytosis\|phagocytosis]] by [[White blood cells\|white blood cells]]. <ref>Murphy K. (2012)Janeway's Immunobiology (8th edition)Newyork;Garland Scienece. Page 729</ref>		Haemolytic disease of the new born occurs when Rh positive foetal RBCs cross the placenta and enter the Rh negative mother’s blood stream. The Rhesus antigens expressed on the foetal RBCs are recognised as foreign to the maternal immune system and [[IgG\|IgG]] antibodies are raised against them. These maternal anti-Rh IgGs are capable of crossing the placenta and coating the foetal RBCs, enabling [[Phagocytosis\|phagocytosis]] by [[White blood cells\|white blood cells]] <ref>Murphy K. (2012)Janeway's Immunobiology (8th edition)Newyork;Garland Scienece. Page 729</ref>.

			=== References ===

			<references />

120285884 at 19:00, 23 October 2013

2013-10-23T19:00:12Z

← Older revision		Revision as of 19:00, 23 October 2013
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	Haemolytic disease of the new born (Erythroblastosis fetalis) is a disease in which Rhesus incompatibility between a mother and a foetus causes the mothers immune system to attack and destroy the foetal [[Red blood cells\|RBCs]]. This results in severe haemolytic anaemia and the associated issues of intravascular coagulation, damage to the [[Heart\|heart and]] [[Lungs\|lungs]], jaundice and swelling of the[[Liver\|liver and]] spleen in the foetus.<ref ~~name="null"~~>Patton, T. (2010)The human body in health and disease (5th ed). Missouri; Mosby Elsevier. Chapter 12, page 355</ref>~~ ~~		Haemolytic disease of the new born (Erythroblastosis fetalis) is a disease in which Rhesus incompatibility between a mother and a foetus causes the mothers immune system to attack and destroy the foetal [[Red blood cells\|RBCs]]. This results in severe haemolytic anaemia and the associated issues of intravascular coagulation, damage to the [[Heart\|heart and]] [[Lungs\|lungs]], jaundice and swelling of the[[Liver\|liver and]] spleen in the foetus.<ref>Patton, T. (2010)The human body in health and disease (5th ed). Missouri; Mosby Elsevier. Chapter 12, page 355</ref>

	<u>Cause</u>		<u>Cause</u>

	Haemolytic disease of the new born occurs when Rh positive foetal RBCs cross the placenta and enter the Rh negative mother’s blood stream. The Rhesus antigens expressed on the foetal RBCs are recognised as foreign to the maternal immune system and [[IgG\|IgG]] antibodies are raised against them. These maternal anti-Rh IgGs are capable of crossing the placenta and coating the foetal RBCs, enabling [[Phagocytosis\|phagocytosis]] by [[White blood cells\|white blood cells]]. <ref>Murphy K. (2012)Janeway's Immunobiology (8th edition)Newyork;Garland Scienece. Page 729</ref>		Haemolytic disease of the new born occurs when Rh positive foetal RBCs cross the placenta and enter the Rh negative mother’s blood stream. The Rhesus antigens expressed on the foetal RBCs are recognised as foreign to the maternal immune system and [[IgG\|IgG]] antibodies are raised against them. These maternal anti-Rh IgGs are capable of crossing the placenta and coating the foetal RBCs, enabling [[Phagocytosis\|phagocytosis]] by [[White blood cells\|white blood cells]]. <ref>Murphy K. (2012)Janeway's Immunobiology (8th edition)Newyork;Garland Scienece. Page 729</ref>

120285884 at 18:58, 23 October 2013

2013-10-23T18:58:54Z

← Older revision		Revision as of 18:58, 23 October 2013
Line 1:		Line 1:
	Haemolytic disease of the new born (Erythroblastosis fetalis) is a disease in which Rhesus incompatibility between a mother and a foetus causes the mothers immune system to attack and destroy the foetal [[Red blood cells\|RBCs]]. This results in severe haemolytic anaemia and the associated issues of intravascular coagulation, damage to the [[Heart\|heart and]] [[Lungs\|lungs]], jaundice and swelling of the[[Liver\|liver and]] spleen in the foetus.<ref>Patton, T. (2010)The human body in health and disease (5th ed). Missouri; Mosby Elsevier. Chapter 12, page 355</ref>		Haemolytic disease of the new born (Erythroblastosis fetalis) is a disease in which Rhesus incompatibility between a mother and a foetus causes the mothers immune system to attack and destroy the foetal [[Red blood cells\|RBCs]]. This results in severe haemolytic anaemia and the associated issues of intravascular coagulation, damage to the [[Heart\|heart and]] [[Lungs\|lungs]], jaundice and swelling of the[[Liver\|liver and]] spleen in the foetus.<ref name="null">Patton, T. (2010)The human body in health and disease (5th ed). Missouri; Mosby Elsevier. Chapter 12, page 355</ref>

	<u>Cause</u>		<u>Cause</u>

	Haemolytic disease of the new born occurs when Rh positive foetal RBCs cross the placenta and enter the Rh negative mother’s blood stream. The Rhesus antigens expressed on the foetal RBCs are recognised as foreign to the maternal immune system and [[IgG\|IgG]] antibodies are raised against them. These maternal anti-Rh IgGs are capable of crossing the placenta and coating the foetal RBCs, enabling [[Phagocytosis\|phagocytosis]] by [[White blood cells\|white blood cells]]. <ref>Murphy K. (2012)Janeway's Immunobiology (8th edition)Newyork;Garland Scienece. Page 729</ref>		Haemolytic disease of the new born occurs when Rh positive foetal RBCs cross the placenta and enter the Rh negative mother’s blood stream. The Rhesus antigens expressed on the foetal RBCs are recognised as foreign to the maternal immune system and [[IgG\|IgG]] antibodies are raised against them. These maternal anti-Rh IgGs are capable of crossing the placenta and coating the foetal RBCs, enabling [[Phagocytosis\|phagocytosis]] by [[White blood cells\|white blood cells]]. <ref>Murphy K. (2012)Janeway's Immunobiology (8th edition)Newyork;Garland Scienece. Page 729</ref>

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2013-10-23T18:58:25Z

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Haemolytic disease of the new born (Erythroblastosis fetalis) is a disease in which Rhesus incompatibility between a mother and a foetus causes the mothers immune system to attack and destroy the foetal [[Red blood cells|RBCs]]. This results in severe haemolytic anaemia and the associated issues of intravascular coagulation, damage to the [[Heart|heart and]] [[Lungs|lungs]], jaundice and swelling of the[[Liver|liver and]] spleen in the foetus.<ref>Patton, T. (2010)The human body in health and disease (5th ed). Missouri; Mosby Elsevier. Chapter 12, page 355</ref> 

<u>Cause</u>

Haemolytic disease of the new born occurs when Rh positive foetal RBCs cross the placenta and enter the Rh negative mother’s blood stream. The Rhesus antigens expressed on the foetal RBCs are recognised as foreign to the maternal immune system and [[IgG|IgG]] antibodies are raised against them. These maternal anti-Rh IgGs are capable of crossing the placenta and coating the foetal RBCs, enabling [[Phagocytosis|phagocytosis]] by [[White blood cells|white blood cells]]. <ref>Murphy K. (2012)Janeway's Immunobiology (8th edition)Newyork;Garland Scienece. Page 729</ref>