Long-term Depression (LTD) - Revision history

Nnjm2 at 12:59, 24 November 2014

2014-11-24T12:59:00Z

← Older revision		Revision as of 12:59, 24 November 2014
Line 1:		Line 1:
	Long-term depression, in opposite of [[Long-term Potentiation]] (LTP), decreases the efficacy of synapse transmission due to repeated stimulation of neurons. <br>		Long-term depression, in opposite of [[Long-term Potentiation]] (LTP), decreases the efficacy of synapse transmission due to repeated stimulation of [[Neuron\|neurons]]. <br>

	As in a typical axon, the neuron is depolarized due to increase in number of sodium ions. [[Depolarisation]] causes the opening of calcium ions channel on [[Presynaptic membrane]] and so calcium ions diffuse into the synapse by [[Facilitated diffusion]]. The presence of calcium ions in the synapse induces the release of [[Neurotransmitter]] into the synaptic cleft. In this case, glutamate are the neurotransmitters.		As in a typical axon, the neuron is depolarized due to increase in number of sodium ions. [[Depolarisation]] causes the opening of calcium ions channel on [[Presynaptic membrane]] and so calcium ions diffuse into the synapse by [[Facilitated diffusion]]. The presence of calcium ions in the synapse induces the release of [[Neurotransmitter]] into the synaptic cleft. In this case, glutamate are the neurotransmitters.<br>

	<br>		There are two types of receptor present in [[Postsynaptic membrane\|post-synaptic membrane]], which are [[α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid\|α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid]] (AMPA) and [[N-methyl-D-aspartate receptor\|N-methyl-D-aspartate receptor]] (NMDA). Glutamate binds to AMPA receptor and allows sodium ions to enter the post-synaptic membrane. Post-synaptic membrane is depolarized. NMDA remains unchanged even though glutamate have bound into the binding site because magnesium ions are present in the receptor. As time goes, the more the post-synaptic membrane gets depolarized, the magnesium ions in NMDA receptor are eventually emitted. Calcium ions that are largely present in synaptic cleft enter the post-synaptic membrane through NMDA receptor and cause sodium ions to diffuse in.<br>

	~~There are two types of receptor present in~~ [[~~Postsynaptic membrane~~\|~~post-synaptic membrane~~]]~~, which are α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) ~~and ~~N-methyl-D-aspartate receptor (NMDA)~~.~~Glutamate binds to~~ AMPA receptor and ~~allows~~ sodium ions to ~~enter the post-synaptic membrane~~. ~~Post-synaptic membrane~~ is ~~depolarized~~. ~~NMDA remains unchanged even though glutamate have bound into the binding site because magnesium ions are present in the receptor~~. ~~As time goes~~, ~~the more the post-synaptic membrane gets depolarized~~, the magnesium ions in NMDA receptor are eventually emitted. Calcium ions that are largely present in synaptic cleft enter the post-synaptic membrane through NMDA receptor and cause sodium ions to diffuse in.		Calcium ions bind to [[Protein_kinase_C\|protein kinase C]] and thus [[kinase\|kinase]] gets phosphorylated. Phosphorylation of protein kinase C results in addition of phosphate group into AMPA receptor and makes AMPA channel more sensitive to diffusion of sodium ions. At the same time, calcium ions tend to bind to another molecule called [[Protein phosphatase]], enzymes that pluck phosphate groups off proteins. Therefore, if LTP is putting phosphate groups on, LTD apparently is taking them off.<ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:782</ref>

	<br>		Moreover, the induction of LTD can also be associated with the internalization of AMPA receptors at the synapse. Thus, LTP and LTD appear to reflect the bidirectional regulation of both the phosphorylation and the number of post-synaptic AMPA receptors <ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:783</ref>.

	Calcium ions bind to protein kinase C and thus kinase gets phosphorylated. Phosphorylation of protein kinase C results in addition of phosphate group into AMPA receptor and makes AMPA channel more sensitive to diffusion of sodium ions. At the same time, calcium ions tend to bind to another molecule called [[Protein phosphatase]], enzymes that pluck phosphate groups off proteins. Therefore, if LTP is putting phosphate groups on, LTD apparently is taking them off.<ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:782</ref><br><br>Moreover, the induction of LTD can also be associated with the internalization of AMPA receptors at the synapse. Thus, LTP and LTD appear to reflect the bidirectional regulation of both the phosphorylation and the number of post-synaptic AMPA receptors.<ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:783</ref><br><br>This complementarity suggests that LTD and LTP reversibly affect synaptic efficiency by acting at a common site. <ref>Purves D, Augustine GJ, Fitzpatrick D, et al.,2001</ref>		This complementarity suggests that LTD and LTP reversibly affect synaptic efficiency by acting at a common site <ref>Purves D, Augustine GJ, Fitzpatrick D, et al.,2001</ref>.

	= ~~<br><br>~~Reference =		=== Reference ===

	~~<br>~~<references /><~~references /><references /~~>		<references /><br>

150015868 at 11:36, 24 November 2014

2014-11-24T11:36:55Z

← Older revision		Revision as of 11:36, 24 November 2014
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	Calcium ions bind to protein kinase C and thus kinase gets phosphorylated. Phosphorylation of protein kinase C results in addition of phosphate group into AMPA receptor and makes AMPA channel more sensitive to diffusion of sodium ions. At the same time, calcium ions tend to bind to another molecule called [[Protein phosphatase]], enzymes that pluck phosphate groups off proteins. Therefore, if LTP is putting phosphate groups on, LTD apparently is taking them off.<ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:782</ref><br><br>Moreover, the induction of LTD can also be associated with the internalization of AMPA receptors at the synapse. Thus, LTP and LTD appear to reflect the bidirectional regulation of both the phosphorylation and the number of post-synaptic AMPA receptors.<ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:783</ref><br><br>This complementarity suggests that LTD and LTP reversibly affect synaptic efficiency by acting at a common site. <ref>Purves D, Augustine GJ, Fitzpatrick D, et al.,2001</ref>		Calcium ions bind to protein kinase C and thus kinase gets phosphorylated. Phosphorylation of protein kinase C results in addition of phosphate group into AMPA receptor and makes AMPA channel more sensitive to diffusion of sodium ions. At the same time, calcium ions tend to bind to another molecule called [[Protein phosphatase]], enzymes that pluck phosphate groups off proteins. Therefore, if LTP is putting phosphate groups on, LTD apparently is taking them off.<ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:782</ref><br><br>Moreover, the induction of LTD can also be associated with the internalization of AMPA receptors at the synapse. Thus, LTP and LTD appear to reflect the bidirectional regulation of both the phosphorylation and the number of post-synaptic AMPA receptors.<ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:783</ref><br><br>This complementarity suggests that LTD and LTP reversibly affect synaptic efficiency by acting at a common site. <ref>Purves D, Augustine GJ, Fitzpatrick D, et al.,2001</ref>

	= <br><br>Reference ~~<references />~~ =		= <br><br>Reference =

	<br>~~1.Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,(2006) Neuroscience,3rd edition,Baltimore(MD):Lippincott Williams & Wilkins~~<br>~~2.Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,(2006) Neuroscience,3rd edition,Baltimore(MD):Lippincott Williams & Wilkins~~<br>~~3.Purves D ,Augustine GJ ,Fitzpatrick D,et al. ,editors ,(2001) Neuroscience,2nd edition,Sunderland(MA):Sinauer Associates~~		<br><references /><references /><references />

150015868 at 11:34, 24 November 2014

2014-11-24T11:34:29Z

← Older revision		Revision as of 11:34, 24 November 2014
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	Calcium ions bind to protein kinase C and thus kinase gets phosphorylated. Phosphorylation of protein kinase C results in addition of phosphate group into AMPA receptor and makes AMPA channel more sensitive to diffusion of sodium ions. At the same time, calcium ions tend to bind to another molecule called [[Protein phosphatase]], enzymes that pluck phosphate groups off proteins. Therefore, if LTP is putting phosphate groups on, LTD apparently is taking them off.<ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:782</ref><br><br>Moreover, the induction of LTD can also be associated with the internalization of AMPA receptors at the synapse. Thus, LTP and LTD appear to reflect the bidirectional regulation of both the phosphorylation and the number of post-synaptic AMPA receptors.<ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:783</ref><br><br>This complementarity suggests that LTD and LTP reversibly affect synaptic efficiency by acting at a common site. <ref>Purves D, Augustine GJ, Fitzpatrick D, et al.,2001</ref>		Calcium ions bind to protein kinase C and thus kinase gets phosphorylated. Phosphorylation of protein kinase C results in addition of phosphate group into AMPA receptor and makes AMPA channel more sensitive to diffusion of sodium ions. At the same time, calcium ions tend to bind to another molecule called [[Protein phosphatase]], enzymes that pluck phosphate groups off proteins. Therefore, if LTP is putting phosphate groups on, LTD apparently is taking them off.<ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:782</ref><br><br>Moreover, the induction of LTD can also be associated with the internalization of AMPA receptors at the synapse. Thus, LTP and LTD appear to reflect the bidirectional regulation of both the phosphorylation and the number of post-synaptic AMPA receptors.<ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:783</ref><br><br>This complementarity suggests that LTD and LTP reversibly affect synaptic efficiency by acting at a common site. <ref>Purves D, Augustine GJ, Fitzpatrick D, et al.,2001</ref>

	= <br><br>~~'''~~Reference~~'''~~ =		= <br><br>Reference <references /> =

	<br>1.Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,(2006) Neuroscience,3rd edition,Baltimore(MD):Lippincott Williams & Wilkins<br>2.Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,(2006) Neuroscience,3rd edition,Baltimore(MD):Lippincott Williams & Wilkins<br>3.Purves D ,Augustine GJ ,Fitzpatrick D,et al. ,editors ,(2001) Neuroscience,2nd edition,Sunderland(MA):Sinauer Associates		<br>1.Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,(2006) Neuroscience,3rd edition,Baltimore(MD):Lippincott Williams & Wilkins<br>2.Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,(2006) Neuroscience,3rd edition,Baltimore(MD):Lippincott Williams & Wilkins<br>3.Purves D ,Augustine GJ ,Fitzpatrick D,et al. ,editors ,(2001) Neuroscience,2nd edition,Sunderland(MA):Sinauer Associates

150015868 at 11:34, 24 November 2014

2014-11-24T11:34:00Z

← Older revision		Revision as of 11:34, 24 November 2014
Line 9:		Line 9:
	<br>		<br>

	Calcium ions bind to protein kinase C and thus kinase gets phosphorylated. Phosphorylation of protein kinase C results in addition of phosphate group into AMPA receptor and makes AMPA channel more sensitive to diffusion of sodium ions. At the same time, calcium ions tend to bind to another molecule called [[Protein phosphatase]], enzymes that pluck phosphate groups off proteins. Therefore, if LTP is putting phosphate groups on, LTD apparently is taking them off.<ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:782</ref><br><br>Moreover, the induction of LTD can also be associated with the internalization of AMPA receptors at the synapse. Thus, LTP and LTD appear to reflect the bidirectional regulation of both the phosphorylation and the number of post-synaptic AMPA receptors.<ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:783</ref><br><br>This complementarity suggests that LTD and LTP reversibly affect synaptic efficiency by acting at a common site. <ref>Purves D, Augustine GJ, Fitzpatrick D, et al.,2001</ref>		Calcium ions bind to protein kinase C and thus kinase gets phosphorylated. Phosphorylation of protein kinase C results in addition of phosphate group into AMPA receptor and makes AMPA channel more sensitive to diffusion of sodium ions. At the same time, calcium ions tend to bind to another molecule called [[Protein phosphatase]], enzymes that pluck phosphate groups off proteins. Therefore, if LTP is putting phosphate groups on, LTD apparently is taking them off.<ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:782</ref><br><br>Moreover, the induction of LTD can also be associated with the internalization of AMPA receptors at the synapse. Thus, LTP and LTD appear to reflect the bidirectional regulation of both the phosphorylation and the number of post-synaptic AMPA receptors.<ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:783</ref><br><br>This complementarity suggests that LTD and LTP reversibly affect synaptic efficiency by acting at a common site. <ref>Purves D, Augustine GJ, Fitzpatrick D, et al.,2001</ref>

	<br><br>~~<references />~~<br>1.Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,(2006) Neuroscience,3rd edition,Baltimore(MD):Lippincott Williams & Wilkins<br>2.Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,(2006) Neuroscience,3rd edition,Baltimore(MD):Lippincott Williams & Wilkins<br>3.Purves D ,Augustine GJ ,Fitzpatrick D,et al. ,editors ,(2001) Neuroscience,2nd edition,Sunderland(MA):Sinauer Associates		= <br><br>'''Reference''' =
			<br>1.Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,(2006) Neuroscience,3rd edition,Baltimore(MD):Lippincott Williams & Wilkins<br>2.Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,(2006) Neuroscience,3rd edition,Baltimore(MD):Lippincott Williams & Wilkins<br>3.Purves D ,Augustine GJ ,Fitzpatrick D,et al. ,editors ,(2001) Neuroscience,2nd edition,Sunderland(MA):Sinauer Associates

150015868 at 11:32, 24 November 2014

2014-11-24T11:32:28Z

← Older revision		Revision as of 11:32, 24 November 2014
Line 9:		Line 9:
	<br>		<br>

	Calcium ions bind to protein kinase C and thus kinase gets phosphorylated. Phosphorylation of protein kinase C results in addition of phosphate group into AMPA receptor and makes AMPA channel more sensitive to diffusion of sodium ions. At the same time, calcium ions tend to bind to another molecule called [[Protein phosphatase]], enzymes that pluck phosphate groups off proteins. Therefore, if LTP is putting phosphate groups on, LTD apparently is taking them off.<ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:782</ref><br><br>Moreover, the induction of LTD can also be associated with the internalization of AMPA receptors at the synapse. Thus, LTP and LTD appear to reflect the bidirectional regulation of both the phosphorylation and the number of post-synaptic AMPA receptors.<ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:783</ref><br><br>This complementarity suggests that LTD and LTP reversibly affect synaptic efficiency by acting at a common site. <ref>Purves D, Augustine GJ, Fitzpatrick D, et al.,2001</ref><br><br><references /><br>1.Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,(2006) Neuroscience,3rd edition,Baltimore(MD):Lippincott Williams & Wilkins<br>2.Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,(2006) Neuroscience,3rd edition,Baltimore(MD):Lippincott Williams & Wilkins<br>3.Purves D ,Augustine GJ ,Fitzpatrick D,et al. ,editors ,(2001) Neuroscience,2nd edition,Sunderland(MA):Sinauer Associates		Calcium ions bind to protein kinase C and thus kinase gets phosphorylated. Phosphorylation of protein kinase C results in addition of phosphate group into AMPA receptor and makes AMPA channel more sensitive to diffusion of sodium ions. At the same time, calcium ions tend to bind to another molecule called [[Protein phosphatase]], enzymes that pluck phosphate groups off proteins. Therefore, if LTP is putting phosphate groups on, LTD apparently is taking them off.<ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:782</ref><br><br>Moreover, the induction of LTD can also be associated with the internalization of AMPA receptors at the synapse. Thus, LTP and LTD appear to reflect the bidirectional regulation of both the phosphorylation and the number of post-synaptic AMPA receptors.<ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:783</ref><br><br>This complementarity suggests that LTD and LTP reversibly affect synaptic efficiency by acting at a common site. <ref>Purves D, Augustine GJ, Fitzpatrick D, et al.,2001</ref>

			<br><br><references /><br>1.Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,(2006) Neuroscience,3rd edition,Baltimore(MD):Lippincott Williams & Wilkins<br>2.Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,(2006) Neuroscience,3rd edition,Baltimore(MD):Lippincott Williams & Wilkins<br>3.Purves D ,Augustine GJ ,Fitzpatrick D,et al. ,editors ,(2001) Neuroscience,2nd edition,Sunderland(MA):Sinauer Associates

150015868: Created page with "Long-term depression, in opposite of Long-term Potentiation (LTP), decreases the efficacy of synapse transmission due to repeated stimulation of neurons.
As in a t..."

2014-11-24T11:30:18Z

Created page with "Long-term depression, in opposite of Long-term Potentiation (LTP), decreases the efficacy of synapse transmission due to repeated stimulation of neurons. As in a t..."

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Long-term depression, in opposite of [[Long-term Potentiation]] (LTP), decreases the efficacy of synapse transmission due to repeated stimulation of neurons. 

As in a typical axon, the neuron is depolarized due to increase in number of sodium ions. [[Depolarisation]] causes the opening of calcium ions channel on [[Presynaptic membrane]] and so calcium ions diffuse into the synapse by [[Facilitated diffusion]]. The presence of calcium ions in the synapse induces the release of [[Neurotransmitter]] into the synaptic cleft. In this case, glutamate are the neurotransmitters.

 

There are two types of receptor present in [[Postsynaptic membrane|post-synaptic membrane]], which are α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate receptor (NMDA).Glutamate binds to AMPA receptor and allows sodium ions to enter the post-synaptic membrane. Post-synaptic membrane is depolarized. NMDA remains unchanged even though glutamate have bound into the binding site because magnesium ions are present in the receptor. As time goes, the more the post-synaptic membrane gets depolarized, the magnesium ions in NMDA receptor are eventually emitted. Calcium ions that are largely present in synaptic cleft enter the post-synaptic membrane through NMDA receptor and cause sodium ions to diffuse in.

 

Calcium ions bind to protein kinase C and thus kinase gets phosphorylated. Phosphorylation of protein kinase C results in addition of phosphate group into AMPA receptor and makes AMPA channel more sensitive to diffusion of sodium ions. At the same time, calcium ions tend to bind to another molecule called [[Protein phosphatase]], enzymes that pluck phosphate groups off proteins. Therefore, if LTP is putting phosphate groups on, LTD apparently is taking them off.<ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:782</ref> Moreover, the induction of LTD can also be associated with the internalization of AMPA receptors at the synapse. Thus, LTP and LTD appear to reflect the bidirectional regulation of both the phosphorylation and the number of post-synaptic AMPA receptors.<ref>Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,2006:783</ref> This complementarity suggests that LTD and LTP reversibly affect synaptic efficiency by acting at a common site. <ref>Purves D, Augustine GJ, Fitzpatrick D, et al.,2001</ref> <references /> 1.Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,(2006) Neuroscience,3rd edition,Baltimore(MD):Lippincott Williams & Wilkins 2.Mark F.Bear ,Barry W.Connors ,Michael A.Paradiso ,(2006) Neuroscience,3rd edition,Baltimore(MD):Lippincott Williams & Wilkins 3.Purves D ,Augustine GJ ,Fitzpatrick D,et al. ,editors ,(2001) Neuroscience,2nd edition,Sunderland(MA):Sinauer Associates

Long-term Depression (LTD) - Revision history

Nnjm2 at 12:59, 24 November 2014

150015868 at 11:36, 24 November 2014

150015868 at 11:34, 24 November 2014

150015868 at 11:34, 24 November 2014

150015868 at 11:32, 24 November 2014

150015868: Created page with "Long-term depression, in opposite of Long-term Potentiation (LTP), decreases the efficacy of synapse transmission due to repeated stimulation of neurons. As in a t..."

150015868: Created page with "Long-term depression, in opposite of Long-term Potentiation (LTP), decreases the efficacy of synapse transmission due to repeated stimulation of neurons.
As in a t..."