N-acetylcysteine - Revision history

Nnjm2 at 06:17, 22 October 2015

2015-10-22T06:17:02Z

← Older revision		Revision as of 06:17, 22 October 2015
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	~~=== Background ===~~

	N-acetylcysteine is used as a drug to treat overdose of [[Paracetamol\|Paracetamol]] (Acetaminophen). When Paracetamol is metabolised by the body it is broken down via different pathways into different [[Metabolites\|metabolites]]. Roughly 60% is metabolised via [[Glucuronidation\|glucuronidation]], 35% via [[Sulfation\|sulfation]] and 5% via [[Cytochrome P450\|cytochrome P450]] pathways. The latter converts Paracetamol into a toxic intermediate, [[NAPQI\|NAPQI]] (N-acetyl-p-benzoquinone imine). In small amounts, such as with an ordinary dose of paracetamol, the [[NAPQI\|NAPQI]] is quickly detoxified by conjugation with [[Glutathione\|glutathione]] into a non-toxic [[Metabolite\|metabolite]] which can be excreted out through the [[Kidneys\|kidneys]].		N-acetylcysteine is used as a drug to treat overdose of [[Paracetamol\|Paracetamol]] (Acetaminophen). When Paracetamol is metabolised by the body it is broken down via different pathways into different [[Metabolites\|metabolites]]. Roughly 60% is metabolised via [[Glucuronidation\|glucuronidation]], 35% via [[Sulfation\|sulfation]] and 5% via [[Cytochrome P450\|cytochrome P450]] pathways. The latter converts Paracetamol into a toxic intermediate, [[NAPQI\|NAPQI]] (N-acetyl-p-benzoquinone imine). In small amounts, such as with an ordinary dose of paracetamol, the [[NAPQI\|NAPQI]] is quickly detoxified by conjugation with [[Glutathione\|glutathione]] into a non-toxic [[Metabolite\|metabolite]] which can be excreted out through the [[Kidneys\|kidneys]].

150015259 at 01:33, 22 October 2015

2015-10-22T01:33:49Z

← Older revision		Revision as of 01:33, 22 October 2015
Line 1:		Line 1:
	=== Background ===		=== Background ===

	N-acetylcysteine is used as a drug to treat overdose of [[Paracetamol\|Paracetamol]] (Acetaminophen). When Paracetamol is metabolised by the body it is broken down via different pathways into different [[~~Javascript:void(0);/1413820366838/~~\|metabolites]]. Roughly 60% is metabolised via [[Glucuronidation\|glucuronidation]], 35% via [[Sulfation\|sulfation]] and 5% via [[Cytochrome P450\|cytochrome P450]] pathways. The latter converts Paracetamol into a toxic intermediate, [[NAPQI\|NAPQI]] (N-acetyl-p-benzoquinone imine). In small amounts, such as with an ordinary dose of paracetamol, the [[NAPQI\|NAPQI]] is quickly detoxified by conjugation with [[Glutathione\|glutathione]] into a non-toxic [[Metabolite\|metabolite]] which can be excreted out through the [[Kidneys\|kidneys]].		N-acetylcysteine is used as a drug to treat overdose of [[Paracetamol\|Paracetamol]] (Acetaminophen). When Paracetamol is metabolised by the body it is broken down via different pathways into different [[Metabolites\|metabolites]]. Roughly 60% is metabolised via [[Glucuronidation\|glucuronidation]], 35% via [[Sulfation\|sulfation]] and 5% via [[Cytochrome P450\|cytochrome P450]] pathways. The latter converts Paracetamol into a toxic intermediate, [[NAPQI\|NAPQI]] (N-acetyl-p-benzoquinone imine). In small amounts, such as with an ordinary dose of paracetamol, the [[NAPQI\|NAPQI]] is quickly detoxified by conjugation with [[Glutathione\|glutathione]] into a non-toxic [[Metabolite\|metabolite]] which can be excreted out through the [[Kidneys\|kidneys]].

	However, when an overdose of [[Paracetamol\|Paracetamol]] is taken, the [[NAPQI\|NAPQI]] produced can quickly use up the available of [[Glutathione\|glutathione]] in the liver, meaning there is a lot of unmetabolised NAPQI left over. This is extremely toxic to [[Liver\|liver]] tissue, as well as being a strong [[Oxidise\|biochemical oxidizer]] and can cause liver damage and eventually death if left untreated.<br>		However, when an overdose of [[Paracetamol\|Paracetamol]] is taken, the [[NAPQI\|NAPQI]] produced can quickly use up the available of [[Glutathione\|glutathione]] in the liver, meaning there is a lot of unmetabolised NAPQI left over. This is extremely toxic to [[Liver\|liver]] tissue, as well as being a strong [[Oxidise\|biochemical oxidizer]] and can cause liver damage and eventually death if left untreated.<br>

	=== Uses ===		=== Uses ===

	'''N-acetylcysteine''' is given as a treatment for Parcetamol overdose as it is a precursor to [[Glutathione\|glutathione]] and hence helps to restore quantities of the substance in the liver. This means remaining NAPQI can be broken down to avoid damage to the liver.		'''N-acetylcysteine''' is given as a treatment for Parcetamol overdose as it is a precursor to [[Glutathione\|glutathione]] and hence helps to restore quantities of the substance in the liver. This means remaining NAPQI can be broken down to avoid damage to the liver.

Nnjm2 at 01:33, 24 October 2014

2014-10-24T01:33:48Z

← Older revision		Revision as of 01:33, 24 October 2014
Line 1:		Line 1:
	Background~~''' '''~~ ===		=== Background ===

	N-acetylcysteine is used as a drug to treat overdose of [[Paracetamol\|Paracetamol]] (Acetaminophen). When Paracetamol is metabolised by the body it is broken down via different pathways into different [[Javascript:void(0);/1413820366838/\|metabolites]]. Roughly 60% is metabolised via [[Glucuronidation\|glucuronidation]], 35% via [[Sulfation\|sulfation]] and 5% via [[Cytochrome P450\|cytochrome P450]] pathways. The latter converts Paracetamol into a toxic intermediate, [[NAPQI\|NAPQI]] (N-acetyl-p-benzoquinone imine). In small amounts, such as with an ordinary dose of paracetamol, the [[NAPQI\|NAPQI]] is quickly detoxified by conjugation with [[Glutathione\|glutathione]] into a non-toxic [[Metabolite\|metabolite]] which can be excreted out through the [[Kidneys\|kidneys]].		N-acetylcysteine is used as a drug to treat overdose of [[Paracetamol\|Paracetamol]] (Acetaminophen). When Paracetamol is metabolised by the body it is broken down via different pathways into different [[Javascript:void(0);/1413820366838/\|metabolites]]. Roughly 60% is metabolised via [[Glucuronidation\|glucuronidation]], 35% via [[Sulfation\|sulfation]] and 5% via [[Cytochrome P450\|cytochrome P450]] pathways. The latter converts Paracetamol into a toxic intermediate, [[NAPQI\|NAPQI]] (N-acetyl-p-benzoquinone imine). In small amounts, such as with an ordinary dose of paracetamol, the [[NAPQI\|NAPQI]] is quickly detoxified by conjugation with [[Glutathione\|glutathione]] into a non-toxic [[Metabolite\|metabolite]] which can be excreted out through the [[Kidneys\|kidneys]].

	However, when an overdose of [[Paracetamol\|Paracetamol]] is taken, the [[NAPQI\|NAPQI]] produced can quickly use up the available of [[Glutathione\|glutathione]] in the liver, meaning there is a lot of unmetabolised NAPQI left over. This is extremely toxic to [[Liver\|liver]] tissue, as well as being a strong [[Oxidise\|biochemical oxidizer]] and can cause liver damage and eventually death if left untreated.<br>		However, when an overdose of [[Paracetamol\|Paracetamol]] is taken, the [[NAPQI\|NAPQI]] produced can quickly use up the available of [[Glutathione\|glutathione]] in the liver, meaning there is a lot of unmetabolised NAPQI left over. This is extremely toxic to [[Liver\|liver]] tissue, as well as being a strong [[Oxidise\|biochemical oxidizer]] and can cause liver damage and eventually death if left untreated.<br>
	===
			=== Uses ===

	'''N-acetylcysteine''' is given as a treatment for Parcetamol overdose as it is a precursor to [[Glutathione\|glutathione]] and hence helps to restore quantities of the substance in the liver. This means remaining NAPQI can be broken down to avoid damage to the liver.		'''N-acetylcysteine''' is given as a treatment for Parcetamol overdose as it is a precursor to [[Glutathione\|glutathione]] and hence helps to restore quantities of the substance in the liver. This means remaining NAPQI can be broken down to avoid damage to the liver.

Nnjm2 at 01:33, 24 October 2014

2014-10-24T01:33:13Z

← Older revision		Revision as of 01:33, 24 October 2014
Line 1:		Line 1:
	'''~~Background~~ '''		Background''' ''' ===

	N-acetylcysteine is used as a drug to treat overdose of [[Paracetamol\|Paracetamol ]](Acetaminophen). When [[Paracetamol~~\|Paracetamol ]]~~is metabolised by the body it is broken down via different pathways into different [[~~javascript~~:void(0);/1413820366838/\|metabolites]]. Roughly 60% is metabolised via [[~~glucuronidation~~\|glucuronidation]], 35% via [[~~sulfation~~\|sulfation]] and 5% via [[~~cytochrome~~ P450\|cytochrome P450]] pathways. The latter converts Paracetamol into a toxic intermediate, [[NAPQI\|NAPQI]] (N-acetyl-p-benzoquinone imine). In small amounts, such as with an ordinary dose of paracetamol, the [[NAPQI\|NAPQI]] is quickly detoxified by conjugation with [[Glutathione\|glutathione]] into a non-toxic [[Metabolite\|metabolite]] which can be excreted out through the [[Kidneys\|kidneys]].		N-acetylcysteine is used as a drug to treat overdose of [[Paracetamol\|Paracetamol]] (Acetaminophen). When Paracetamol is metabolised by the body it is broken down via different pathways into different [[Javascript:void(0);/1413820366838/\|metabolites]]. Roughly 60% is metabolised via [[Glucuronidation\|glucuronidation]], 35% via [[Sulfation\|sulfation]] and 5% via [[Cytochrome P450\|cytochrome P450]] pathways. The latter converts Paracetamol into a toxic intermediate, [[NAPQI\|NAPQI]] (N-acetyl-p-benzoquinone imine). In small amounts, such as with an ordinary dose of paracetamol, the [[NAPQI\|NAPQI]] is quickly detoxified by conjugation with [[Glutathione\|glutathione]] into a non-toxic [[Metabolite\|metabolite]] which can be excreted out through the [[Kidneys\|kidneys]].

	However, when an overdose of [[Paracetamol\|Paracetamol]] is taken, the [[NAPQI\|NAPQI]] produced can quickly use up the available of [[Glutathione\|glutathione]] in the liver, meaning there is a lot of unmetabolised NAPQI left over. This is extremely toxic to [[Liver\|liver]] tissue, as well as being a strong [[Oxidise\|biochemical oxidizer]] and can cause liver damage and eventually death if left untreated.		However, when an overdose of [[Paracetamol\|Paracetamol]] is taken, the [[NAPQI\|NAPQI]] produced can quickly use up the available of [[Glutathione\|glutathione]] in the liver, meaning there is a lot of unmetabolised NAPQI left over. This is extremely toxic to [[Liver\|liver]] tissue, as well as being a strong [[Oxidise\|biochemical oxidizer]] and can cause liver damage and eventually death if left untreated.<br>
			===


	~~'''Use'''~~

	'''N-acetylcysteine''' is given as a treatment for Parcetamol overdose as it is a precursor to [[Glutathione\|glutathione]] and hence helps to restore quantities of the substance in the liver. This means remaining NAPQI can be broken down to avoid damage to the liver.		'''N-acetylcysteine''' is given as a treatment for Parcetamol overdose as it is a precursor to [[Glutathione\|glutathione]] and hence helps to restore quantities of the substance in the liver. This means remaining NAPQI can be broken down to avoid damage to the liver.

110173056: N-acetylcysteine and its use in the treatment of Paracetamol overdose

2014-10-20T16:09:18Z

N-acetylcysteine and its use in the treatment of Paracetamol overdose

New page

'''Background '''

N-acetylcysteine is used as a drug to treat overdose of [[Paracetamol|Paracetamol ]](Acetaminophen). When [[Paracetamol|Paracetamol ]]is metabolised by the body it is broken down via different pathways into different [[javascript:void(0);/*1413820366838*/|metabolites]]. Roughly 60% is metabolised via [[glucuronidation|glucuronidation]], 35% via [[sulfation|sulfation]] and 5% via [[cytochrome P450|cytochrome P450]] pathways. The latter converts Paracetamol into a toxic intermediate, [[NAPQI|NAPQI]] (N-acetyl-p-benzoquinone imine). In small amounts, such as with an ordinary dose of paracetamol, the [[NAPQI|NAPQI]] is quickly detoxified by conjugation with [[Glutathione|glutathione]] into a non-toxic [[Metabolite|metabolite]] which can be excreted out through the [[Kidneys|kidneys]].

However, when an overdose of [[Paracetamol|Paracetamol]] is taken, the [[NAPQI|NAPQI]] produced can quickly use up the available of [[Glutathione|glutathione]] in the liver, meaning there is a lot of unmetabolised NAPQI left over. This is extremely toxic to [[Liver|liver]] tissue, as well as being a strong [[Oxidise|biochemical oxidizer]] and can cause liver damage and eventually death if left untreated.

'''Use'''

'''N-acetylcysteine''' is given as a treatment for Parcetamol overdose as it is a precursor to [[Glutathione|glutathione]] and hence helps to restore quantities of the substance in the liver. This means remaining NAPQI can be broken down to avoid damage to the liver.