Nephrogenic diabetes insipidus - Revision history

Nnjm2 at 10:54, 12 November 2011

2011-11-12T10:54:44Z

← Older revision		Revision as of 10:54, 12 November 2011
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	Nephrogenic diabetes insipidus can be cuased by a mutation of Aquaporin 2 (AQ2). The mutations are K228E, V24A and R187C. These mutations could cause structural defects in the water channel affecting their permeablitity and functionality. These defects can cause the renal collecting duct not to respond to ADH and this releases excessive amounts of water in the urine. The urine should be concentrated, as ADH makes the urine more concentrated to maintain the water in your body therefore AQ2 will not reabsorb water from the kidney, resulting in abnormal water loss.		Nephrogenic diabetes insipidus can be cuased by a mutation of [[Aquaporin_2\|Aquaporin 2]] (AQ2). The mutations are K228E, V24A and R187C. These mutations could cause structural defects in the [[Water\|water]] channel affecting their permeablitity and functionality. These defects can cause the [[renal collecting duct\|renal collecting duct]] not to respond to [[ADH_(anti-diuretic_hormone)\|ADH]] and this releases excessive amounts of water in the [[urine\|urine]]. The urine should be concentrated, as ADH makes the urine more concentrated to maintain the water in your body therefore AQ2 will not reabsorb water from the [[Kidney\|kidney]], resulting in abnormal water loss.

	Symptoms		=== Symptoms ===

	Sufferers may have insupressible thirst and will urinate a vast amount, usually more than 3 - 15 liters per day. Dehydration can occur if insufficent fluids are consumed. This can result in dry mucous membranes, dry skin, sunken appearance to eyes and sunken fontanelles (soft spot) in infants.		Sufferers may have insupressible thirst and will urinate a vast amount, usually more than 3 - 15 liters per day. Dehydration can occur if insufficent fluids are consumed. This can result in dry [[mucous membranes\|mucous membranes]], dry skin, sunken appearance to eyes and sunken fontanelles (soft spot) in infants.

	Other symptoms that can occur due to inadequate fluids include:~~<br>•Fatigue~~, lethargy~~<br>•Headache<br>•Irritability<br>•Low~~ body temperature~~<br>•Muscle~~ pains~~<br>•Rapid~~ heart rate~~<br>•Weight~~ loss<br>		Other symptoms that can occur due to inadequate fluids include:

			*Fatigue, lethargy
			*Headache
			*Irritability
			*Low body temperature
			*Muscle pains
			*Rapid heart rate
			*Weight loss<br>

101207405 at 10:47, 11 November 2011

2011-11-11T10:47:11Z

← Older revision		Revision as of 10:47, 11 November 2011
Line 1:		Line 1:
	Nephrogenic diabetes insipidus can be cuased by a mutation of Aquaporin 2 (AQ2). The mutations are K228E, V24A and R187C. These mutations could cause structural defects in the water channel affecting their permeablitity and functionality. These defects can cause the renal collecting duct not to respond to ADH and this releases excessive amounts of water in the urine. The urine should be concentrated, as ADH makes the urine more concentrated to maintain the water in your body therefore AQ2 will not reabsorb water from the kidney, resulting in abnormal water loss.		Nephrogenic diabetes insipidus can be cuased by a mutation of Aquaporin 2 (AQ2). The mutations are K228E, V24A and R187C. These mutations could cause structural defects in the water channel affecting their permeablitity and functionality. These defects can cause the renal collecting duct not to respond to ADH and this releases excessive amounts of water in the urine. The urine should be concentrated, as ADH makes the urine more concentrated to maintain the water in your body therefore AQ2 will not reabsorb water from the kidney, resulting in abnormal water loss.

			Symptoms

			Sufferers may have insupressible thirst and will urinate a vast amount, usually more than 3 - 15 liters per day. Dehydration can occur if insufficent fluids are consumed. This can result in dry mucous membranes, dry skin, sunken appearance to eyes and sunken fontanelles (soft spot) in infants.

			Other symptoms that can occur due to inadequate fluids include:<br>•Fatigue, lethargy<br>•Headache<br>•Irritability<br>•Low body temperature<br>•Muscle pains<br>•Rapid heart rate<br>•Weight loss<br>

100698116: Created page with "Nephrogenic diabetes insipidus can be cuased by a mutation of Aquaporin 2 (AQ2). The mutations are K228E, V24A and R187C. These mutations could cause structural defects in t..."

2011-11-04T12:17:41Z

Created page with "Nephrogenic diabetes insipidus can be cuased by a mutation of Aquaporin 2 (AQ2). The mutations are K228E, V24A and R187C. These mutations could cause structural defects in t..."

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Nephrogenic diabetes insipidus can be cuased by a mutation of Aquaporin 2 (AQ2). The mutations are K228E, V24A and R187C. These mutations could cause structural defects in the water channel affecting their permeablitity and functionality. These defects can cause the renal collecting duct not to respond to ADH and this releases excessive amounts of water in the urine. The urine should be concentrated, as ADH makes the urine more concentrated to maintain the water in your body therefore AQ2 will not reabsorb water from the kidney, resulting in abnormal water loss.