Nuclear receptors - Revision history

180354458: Added a link

2018-12-06T16:29:39Z

Added a link

← Older revision		Revision as of 16:29, 6 December 2018
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	Nuclear receptors are [[Intracellular receptors\|intracellular receptors]], found in either in the cytosol or in the [[Nucleus\|nucleus]], bind ligands such as [[Steroid hormones\|steroid hormones]], thyroid hormones and fat-soluble [[Vitamin A\|vitamin A]] and [[Vitamin D\|vitamin D]]<ref>Chawla A., Repa J., Evans R., et al. Nuclear Receptors and Lipid Physiology. Opening the X-Files. Science 2001; 294(5548):1866-1870.</ref> .		Nuclear receptors are [[Intracellular receptors\|intracellular receptors]], found in either in the [[Cytosol\|cytosol]] or in the [[Nucleus\|nucleus]], bind ligands such as [[Steroid hormones\|steroid hormones]], thyroid hormones and fat-soluble [[Vitamin A\|vitamin A]] and [[Vitamin D\|vitamin D]]<ref>Chawla A., Repa J., Evans R., et al. Nuclear Receptors and Lipid Physiology. Opening the X-Files. Science 2001; 294(5548):1866-1870.</ref> .

	Binding of the ligand causes a conformational change in the receptor resulting in the dissociation of chaperone proteins from the receptor to reveal sequence-specific binding sites. This increases its affinity of the nuclear-receptor complex for the specific chromosome binding site. Contrastingly, ligand binding can also act as a transcription repressor. Thus, nuclear receptors, along with their ligands work to regulate [[Transcription\|transcription]] and [[Gene expression\|gene expression]]<ref>Alberts B. Molecular biology of the cell. 5th ed. New York: Garland Science Taylor &amp;amp; Francis. 2008</ref>.		Binding of the ligand causes a conformational change in the receptor resulting in the dissociation of chaperone proteins from the receptor to reveal sequence-specific binding sites. This increases its affinity of the nuclear-receptor complex for the specific chromosome binding site. Contrastingly, ligand binding can also act as a transcription repressor. Thus, nuclear receptors, along with their ligands work to regulate [[Transcription\|transcription]] and [[Gene expression\|gene expression]]<ref>Alberts B. Molecular biology of the cell. 5th ed. New York: Garland Science Taylor &amp;amp;amp; Francis. 2008</ref>.

	=== References ===		=== References ===

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Nnjm2 at 09:27, 6 December 2017

2017-12-06T09:27:50Z

← Older revision		Revision as of 09:27, 6 December 2017
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	~~ ~~Nuclear receptors are [[Intracellular receptors\|intracellular receptors]], found in either in the cytosol or in the [[Nucleus\|nucleus]], bind ligands such as [[Steroid hormones\|steroid hormones]], thyroid hormones and fat-soluble [[Vitamin A\|vitamin A]] and [[Vitamin D\|vitamin D]] <ref>Chawla A., Repa J., Evans R., et al. Nuclear Receptors and Lipid Physiology. Opening the X-Files. Science 2001; 294(5548):1866-1870.</ref> .		Nuclear receptors are [[Intracellular receptors\|intracellular receptors]], found in either in the cytosol or in the [[Nucleus\|nucleus]], bind ligands such as [[Steroid hormones\|steroid hormones]], thyroid hormones and fat-soluble [[Vitamin A\|vitamin A]] and [[Vitamin D\|vitamin D]]<ref>Chawla A., Repa J., Evans R., et al. Nuclear Receptors and Lipid Physiology. Opening the X-Files. Science 2001; 294(5548):1866-1870.</ref> .

	Binding of the ligand causes a conformational change in the receptor resulting in the dissociation of chaperone proteins from the receptor to reveal sequence specific binding sites. This increases its affinity of the nuclear-receptor complex for the specific chromosome binding site. Contrastingly, ligand binding can also act as a transcription repressor. Thus, nuclear receptors, along with their ligands work to regulate [[Transcription\|transcription]] and [[Gene expression\|gene expression]]<ref>Alberts B. Molecular biology of the cell. 5th ed. New York: Garland Science Taylor &amp; Francis. 2008</ref>.~~<br>~~		Binding of the ligand causes a conformational change in the receptor resulting in the dissociation of chaperone proteins from the receptor to reveal sequence-specific binding sites. This increases its affinity of the nuclear-receptor complex for the specific chromosome binding site. Contrastingly, ligand binding can also act as a transcription repressor. Thus, nuclear receptors, along with their ligands work to regulate [[Transcription\|transcription]] and [[Gene expression\|gene expression]]<ref>Alberts B. Molecular biology of the cell. 5th ed. New York: Garland Science Taylor &amp;amp; Francis. 2008</ref>.

	=== References ===		=== References ===

	<references />		<references />

170726957: Created page with " Nuclear receptors are intracellular receptors, found in either in the cytosol or in the nucleus, bind ligands such as [[Steroid horm..."

2017-12-06T00:20:07Z

Created page with " Nuclear receptors are intracellular receptors, found in either in the cytosol or in the nucleus, bind ligands such as [[Steroid horm..."

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 Nuclear receptors are [[Intracellular receptors|intracellular receptors]], found in either in the cytosol or in the [[Nucleus|nucleus]], bind ligands such as [[Steroid hormones|steroid hormones]], thyroid hormones and fat-soluble [[Vitamin A|vitamin A]] and [[Vitamin D|vitamin D]] <ref>Chawla A., Repa J., Evans R., et al. Nuclear Receptors and Lipid Physiology. Opening the X-Files. Science 2001; 294(5548):1866-1870.</ref> .

Binding of the ligand causes a conformational change in the receptor resulting in the dissociation of chaperone proteins from the receptor to reveal sequence specific binding sites. This increases its affinity of the nuclear-receptor complex for the specific chromosome binding site. Contrastingly, ligand binding can also act as a transcription repressor. Thus, nuclear receptors, along with their ligands work to regulate [[Transcription|transcription]] and [[Gene expression|gene expression]]<ref>Alberts B. Molecular biology of the cell. 5th ed. New York: Garland Science Taylor &amp; Francis. 2008</ref>.<br>

=== References ===

<references />