PS432 - Revision history

Nnjm2: Added the references correctly, that is, I added them as explained in the lecture.

2017-12-05T20:25:44Z

Added the references correctly, that is, I added them as explained in the lecture.

← Older revision		Revision as of 20:25, 5 December 2017
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	PS432 is a molecule which has shown great promise in targeted cancer therapy as it was shown to dramatically reduce the rate of cell division in cancer cells, resulting in declining tumour growth. It does this by allosteric inhibition of protein kinase C~~ ~~<ref>ACS Chem. Biol., 2017, 12 (2), pp 564–573, Arencibia, J., Fröhner, W., Krupa, M., Pastor-Flores, D., Merker, P., Oellerich, T., Neimanis, S., Schmithals, C., Köberle, V., Süß, E., Zeuzem, S., Stark, H., Piiper, A., Odadzic, D., Schulze, J. and Biondi, R. (2017). An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. [online] PUBCS. [Cited 05/12/17] Available at: http://pubs.acs.org/doi/abs/10.1021/acschembio.6b00827</ref>~~ ~~  PS432 has an empirical formula of ~~C23H19CLN205S~~ with a molecular weight of 494.95 daltons~~  ~~<ref>PS432 has an empirical formula of C23H19CLN205S with a molecular weight of 494.95 daltons &lt;ref&gt;Sigma-Aldrich. (2017). PS432 SML1991. [online] Available at: https://www.sigmaaldrich.com/catalog/product/sigma/sml1991?lang=en&amp;region=GB [Accessed 5 Dec. 2017]&lt;/ref&gt;.</ref>		PS432 is a molecule which has shown great promise in targeted [[cancer\|cancer]] therapy as it was shown to dramatically reduce the rate of [[cell division\|cell division]] in cancer cells, resulting in declining tumour growth. It does this by [[allosteric inhibition\|allosteric inhibition]] of [[protein kinase C\|protein kinase C]]<ref>ACS Chem. Biol., 2017, 12 (2), pp 564–573, Arencibia, J., Fröhner, W., Krupa, M., Pastor-Flores, D., Merker, P., Oellerich, T., Neimanis, S., Schmithals, C., Köberle, V., Süß, E., Zeuzem, S., Stark, H., Piiper, A., Odadzic, D., Schulze, J. and Biondi, R. (2017). An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. [online] PUBCS. [Cited 05/12/17] Available at: http://pubs.acs.org/doi/abs/10.1021/acschembio.6b00827</ref>. PS432 has an empirical formula of C<sub>23</sub>H<sub>19</sub>ClN<sub>2</sub>O<sub>5</sub>S with a molecular weight of 494.95 daltons<ref>PS432 has an empirical formula of C23H19CLN205S with a molecular weight of 494.95 daltons &amp;lt;ref&amp;gt;Sigma-Aldrich. (2017). PS432 SML1991. [online] Available at: https://www.sigmaaldrich.com/catalog/product/sigma/sml1991?lang=en&amp;amp;region=GB [Accessed 5 Dec. 2017]&amp;lt;/ref&amp;gt;.</ref>.

			=== References ===

	<references />		<references />

	<br>		<br>

170094085 at 17:44, 5 December 2017

2017-12-05T17:44:44Z

← Older revision		Revision as of 17:44, 5 December 2017
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	PS432 is a molecule which has shown great promise in targeted cancer therapy as it was shown to dramatically reduce the rate of cell division in cancer cells, resulting in declining tumour growth. It does this by allosteric inhibition of protein kinase C <ref>ACS Chem. Biol., 2017, 12 (2), pp 564–573, Arencibia, J., Fröhner, W., Krupa, M., Pastor-Flores, D., Merker, P., Oellerich, T., Neimanis, S., Schmithals, C., Köberle, V., Süß, E., Zeuzem, S., Stark, H., Piiper, A., Odadzic, D., Schulze, J. and Biondi, R. (2017). An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. [online] PUBCS. [Cited 05/12/17] Available at: http://pubs.acs.org/doi/abs/10.1021/acschembio.6b00827</ref>   PS432 has an empirical formula of C23H19CLN205S with a molecular weight of 494.95 daltons  <ref>PS432 has an empirical formula of C23H19CLN205S with a molecular weight of 494.95 daltons <ref>Sigma-Aldrich. (2017). PS432 SML1991. [online] Available at: https://www.sigmaaldrich.com/catalog/product/sigma/sml1991?lang=en&region=GB [Accessed 5 Dec. 2017]</ref>.</ref>		PS432 is a molecule which has shown great promise in targeted cancer therapy as it was shown to dramatically reduce the rate of cell division in cancer cells, resulting in declining tumour growth. It does this by allosteric inhibition of protein kinase C <ref>ACS Chem. Biol., 2017, 12 (2), pp 564–573, Arencibia, J., Fröhner, W., Krupa, M., Pastor-Flores, D., Merker, P., Oellerich, T., Neimanis, S., Schmithals, C., Köberle, V., Süß, E., Zeuzem, S., Stark, H., Piiper, A., Odadzic, D., Schulze, J. and Biondi, R. (2017). An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. [online] PUBCS. [Cited 05/12/17] Available at: http://pubs.acs.org/doi/abs/10.1021/acschembio.6b00827</ref>   PS432 has an empirical formula of C23H19CLN205S with a molecular weight of 494.95 daltons  <ref>PS432 has an empirical formula of C23H19CLN205S with a molecular weight of 494.95 daltons &lt;ref&gt;Sigma-Aldrich. (2017). PS432 SML1991. [online] Available at: https://www.sigmaaldrich.com/catalog/product/sigma/sml1991?lang=en&amp;region=GB [Accessed 5 Dec. 2017]&lt;/ref&gt;.</ref>

	<references />		<references />

	1. ACS Chem. Biol., 2017, 12 (2), pp 564–573, Arencibia, J., Fröhner, W., Krupa, M., Pastor-Flores, D., Merker, P., Oellerich, T., Neimanis, S., Schmithals, C., Köberle, V., Süß, E., Zeuzem, S., Stark, H., Piiper, A., Odadzic, D., Schulze, J. and Biondi, R. (2017). An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. [online] PUBCS. [Cited 05/12/17] Available at: http://pubs.acs.org/doi/abs/10.1021/acschembio.6b00827		<br>

	2. PS432 has an empirical formula of C23H19CLN205S with a molecular weight of 494.95 daltons <ref>Sigma-Aldrich. (2017). PS432 SML1991. [online] Available at: https://www.sigmaaldrich.com/catalog/product/sigma/sml1991?lang=en&region=GB [Accessed 5 Dec. 2017]</ref>.

170094085 at 17:44, 5 December 2017

2017-12-05T17:44:26Z

← Older revision		Revision as of 17:44, 5 December 2017
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	PS432 is a molecule which has shown great promise in targeted cancer therapy as it was shown to dramatically reduce the rate of cell division in cancer cells, resulting in declining tumour growth. It does this by allosteric inhibition of protein kinase C  <~~references~~ />  PS432 has an empirical formula of C23H19CLN205S with a molecular weight of 494.95 daltons  <references />		PS432 is a molecule which has shown great promise in targeted cancer therapy as it was shown to dramatically reduce the rate of cell division in cancer cells, resulting in declining tumour growth. It does this by allosteric inhibition of protein kinase C <ref>ACS Chem. Biol., 2017, 12 (2), pp 564–573, Arencibia, J., Fröhner, W., Krupa, M., Pastor-Flores, D., Merker, P., Oellerich, T., Neimanis, S., Schmithals, C., Köberle, V., Süß, E., Zeuzem, S., Stark, H., Piiper, A., Odadzic, D., Schulze, J. and Biondi, R. (2017). An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. [online] PUBCS. [Cited 05/12/17] Available at: http://pubs.acs.org/doi/abs/10.1021/acschembio.6b00827</ref>   PS432 has an empirical formula of C23H19CLN205S with a molecular weight of 494.95 daltons  <ref>PS432 has an empirical formula of C23H19CLN205S with a molecular weight of 494.95 daltons <ref>Sigma-Aldrich. (2017). PS432 SML1991. [online] Available at: https://www.sigmaaldrich.com/catalog/product/sigma/sml1991?lang=en&region=GB [Accessed 5 Dec. 2017]</ref>.</ref>

			<references />

			1. ACS Chem. Biol., 2017, 12 (2), pp 564–573, Arencibia, J., Fröhner, W., Krupa, M., Pastor-Flores, D., Merker, P., Oellerich, T., Neimanis, S., Schmithals, C., Köberle, V., Süß, E., Zeuzem, S., Stark, H., Piiper, A., Odadzic, D., Schulze, J. and Biondi, R. (2017). An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. [online] PUBCS. [Cited 05/12/17] Available at: http://pubs.acs.org/doi/abs/10.1021/acschembio.6b00827

			2. PS432 has an empirical formula of C23H19CLN205S with a molecular weight of 494.95 daltons <ref>Sigma-Aldrich. (2017). PS432 SML1991. [online] Available at: https://www.sigmaaldrich.com/catalog/product/sigma/sml1991?lang=en&region=GB [Accessed 5 Dec. 2017]</ref>.

170094085 at 17:42, 5 December 2017

2017-12-05T17:42:41Z

← Older revision		Revision as of 17:42, 5 December 2017
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	PS432 is a molecule which has shown great promise in targeted cancer therapy as it was shown to dramatically reduce the rate of cell division in cancer cells, resulting in declining tumour growth. It does this by allosteric inhibition of protein kinase C		PS432 is a molecule which has shown great promise in targeted cancer therapy as it was shown to dramatically reduce the rate of cell division in cancer cells, resulting in declining tumour growth. It does this by allosteric inhibition of protein kinase C  <references />  PS432 has an empirical formula of C23H19CLN205S with a molecular weight of 494.95 daltons  <references />
	<ref>ACS Chem. Biol., 2017, 12 (2), pp 564–573, Arencibia, J., Fröhner, W., Krupa, M., Pastor-Flores, D., Merker, P., Oellerich, T., Neimanis, S., Schmithals, C., Köberle, V., Süß, E., Zeuzem, S., Stark, H., Piiper, A., Odadzic, D., Schulze, J. and Biondi, R. (2017). An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. [online] PUBCS. [Cited 05/12/17] Available at: http:/~~/pubs.acs.org/doi/abs/10.1021/acschembio.6b00827</ref~~>
	PS432 has an empirical formula of C23H19CLN205S with a molecular weight of 494.95 daltons
	~~<ref>Sigma-Aldrich. (2017). PS432 SML1991. [online] Available at: https://www.sigmaaldrich.com/catalog/product/sigma/sml1991?lang=en&region=GB [Accessed 5 Dec. 2017]~~</~~ref~~>

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2017-12-05T17:42:16Z

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PS432 is a molecule which has shown great promise in targeted cancer therapy as it was shown to dramatically reduce the rate of cell division in cancer cells, resulting in declining tumour growth. It does this by allosteric inhibition of protein kinase C 
<ref>ACS Chem. Biol., 2017, 12 (2), pp 564–573, Arencibia, J., Fröhner, W., Krupa, M., Pastor-Flores, D., Merker, P., Oellerich, T., Neimanis, S., Schmithals, C., Köberle, V., Süß, E., Zeuzem, S., Stark, H., Piiper, A., Odadzic, D., Schulze, J. and Biondi, R. (2017). An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. [online] PUBCS. [Cited 05/12/17] Available at: http://pubs.acs.org/doi/abs/10.1021/acschembio.6b00827</ref>
 PS432 has an empirical formula of C23H19CLN205S with a molecular weight of 494.95 daltons 
<ref>Sigma-Aldrich. (2017). PS432 SML1991. [online] Available at: https://www.sigmaaldrich.com/catalog/product/sigma/sml1991?lang=en&region=GB [Accessed 5 Dec. 2017]</ref>