Pharmacogenetics - Revision history

Nnjm2 at 16:33, 16 November 2010

2010-11-16T16:33:37Z

← Older revision		Revision as of 16:33, 16 November 2010
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	Pharmacogenetics is the study of how a patient’s genetic variability can effect drug treatment. Genetic variation can have an effect of the outcome of drug treatment, for example via drug [[Metabolism\|metabolism]] <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>. Drug type and dosage are currently adapted to accommodate differences in patient age, [[Liver\|liver]] and renal function<ref>Pharm. World Sci. 2010 Nov 4. ‘From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics’, Wilffert B, Swen J, Mulder H, Touw D, Maitland-Van der Zee AH, Deneer V; KNMP working group Pharmacogenetics, DOI 10.1007/s11096-010-9446-1</ref> and it is anticipated that pharmacogenetics can be used in the same way to maximise the efficacy of drug treatment as well as reduce the incidence of adverse drug responses.<ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>		Pharmacogenetics is the study of how a patient’s genetic variability can effect drug treatment. Genetic variation can have an effect of the outcome of drug treatment, for example via drug [[Metabolism\|metabolism]] <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>. Drug type and dosage are currently adapted to accommodate differences in patient age, [[Liver\|liver]] and renal function <ref>Pharm. World Sci. 2010 Nov 4. ‘From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics’, Wilffert B, Swen J, Mulder H, Touw D, Maitland-Van der Zee AH, Deneer V; KNMP working group Pharmacogenetics, DOI 10.1007/s11096-010-9446-1</ref> and it is anticipated that pharmacogenetics can be used in the same way to maximise the efficacy of drug treatment as well as reduce the incidence of adverse drug responses <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>.

	Implementation of pharmacogenetics requires knowledge of the genotypic and phenotypic information relating to disease as well as an in-depth understanding of the mechanism of action of the drug.<ref>Becquemont L. Pharmacogenomics of adverse drug reactions: practical applications and perspectives. Pharmacogenomics. 2009;10(6):961–9.</ref> Once this information has been established it is possible to create a tailor-made drug treatment specific to the individual. <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>		Implementation of pharmacogenetics requires knowledge of the genotypic and phenotypic information relating to disease as well as an in-depth understanding of the mechanism of action of the drug <ref>Becquemont L. Pharmacogenomics of adverse drug reactions: practical applications and perspectives. Pharmacogenomics. 2009;10(6):961–9.</ref>. Once this information has been established it is possible to create a tailor-made drug treatment specific to the individual <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>.

	While cost is currently a major factor preventing wide scale use of pharmacogenetics, it is expected that in the future as the cost of [[DNA\|DNA]] sampling, [[DNA Sequencing\|DNA sequencing]] and analysis will decrease as technological advances in the field are made therefore reducing the costs associated with the implementation of pharmacogenetics on a wider scale.<ref>Pharm. World Sci. 2010 Nov 4. ‘From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics’, Wilffert B, Swen J, Mulder H, Touw D, Maitland-Van der Zee AH, Deneer V; KNMP working group Pharmacogenetics, DOI 10.1007/s11096-010-9446-1</ref>		While cost is currently a major factor preventing wide scale use of pharmacogenetics, it is expected that in the future as the cost of [[DNA\|DNA]] sampling, [[DNA Sequencing\|DNA sequencing]] and analysis will decrease as technological advances in the field are made therefore reducing the costs associated with the implementation of pharmacogenetics on a wider scale <ref>Pharm. World Sci. 2010 Nov 4. ‘From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics’, Wilffert B, Swen J, Mulder H, Touw D, Maitland-Van der Zee AH, Deneer V; KNMP working group Pharmacogenetics, DOI 10.1007/s11096-010-9446-1</ref>.

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Nnjm2 at 16:33, 16 November 2010

2010-11-16T16:33:06Z

← Older revision		Revision as of 16:33, 16 November 2010
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	Pharmacogenetics is the study of how a patient’s genetic variability can effect drug treatment. Genetic variation can have an effect of the outcome of drug treatment, for example via drug [[Metabolism\|metabolism]] <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>. Drug type and dosage are currently adapted to accommodate differences in patient age, liver and renal function<ref>Pharm. World Sci. 2010 Nov 4. ‘From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics’, Wilffert B, Swen J, Mulder H, Touw D, Maitland-Van der Zee AH, Deneer V; KNMP working group Pharmacogenetics, DOI 10.1007/s11096-010-9446-1</ref> and it is anticipated that pharmacogenetics can be used in the same way to maximise the efficacy of drug treatment as well as reduce the incidence of adverse drug responses.<ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>		Pharmacogenetics is the study of how a patient’s genetic variability can effect drug treatment. Genetic variation can have an effect of the outcome of drug treatment, for example via drug [[Metabolism\|metabolism]] <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>. Drug type and dosage are currently adapted to accommodate differences in patient age, [[Liver\|liver]] and renal function<ref>Pharm. World Sci. 2010 Nov 4. ‘From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics’, Wilffert B, Swen J, Mulder H, Touw D, Maitland-Van der Zee AH, Deneer V; KNMP working group Pharmacogenetics, DOI 10.1007/s11096-010-9446-1</ref> and it is anticipated that pharmacogenetics can be used in the same way to maximise the efficacy of drug treatment as well as reduce the incidence of adverse drug responses.<ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>

	~~ <br>~~Implementation of pharmacogenetics requires knowledge of the genotypic and phenotypic information relating to disease as well as an in-depth understanding of the mechanism of action of the drug.<ref>Becquemont L. Pharmacogenomics of adverse drug reactions: practical applications and perspectives. Pharmacogenomics. 2009;10(6):961–9.</ref> Once this information has been established it is possible to create a tailor-made drug treatment specific to the individual. <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>		Implementation of pharmacogenetics requires knowledge of the genotypic and phenotypic information relating to disease as well as an in-depth understanding of the mechanism of action of the drug.<ref>Becquemont L. Pharmacogenomics of adverse drug reactions: practical applications and perspectives. Pharmacogenomics. 2009;10(6):961–9.</ref> Once this information has been established it is possible to create a tailor-made drug treatment specific to the individual. <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>

	~~<br>~~While cost is currently a major factor preventing wide scale use of pharmacogenetics, it is expected that in the future as the cost of [[DNA\|DNA]] sampling, [[DNA Sequencing\|DNA sequencing]] and analysis will decrease as technological advances in the field are made therefore reducing the costs associated with the implementation of pharmacogenetics on a wider scale.<ref>Pharm. World Sci. 2010 Nov 4. ‘From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics’, Wilffert B, Swen J, Mulder H, Touw D, Maitland-Van der Zee AH, Deneer V; KNMP working group Pharmacogenetics, DOI 10.1007/s11096-010-9446-1</ref>		While cost is currently a major factor preventing wide scale use of pharmacogenetics, it is expected that in the future as the cost of [[DNA\|DNA]] sampling, [[DNA Sequencing\|DNA sequencing]] and analysis will decrease as technological advances in the field are made therefore reducing the costs associated with the implementation of pharmacogenetics on a wider scale.<ref>Pharm. World Sci. 2010 Nov 4. ‘From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics’, Wilffert B, Swen J, Mulder H, Touw D, Maitland-Van der Zee AH, Deneer V; KNMP working group Pharmacogenetics, DOI 10.1007/s11096-010-9446-1</ref>

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090452844 at 12:51, 16 November 2010

2010-11-16T12:51:15Z

← Older revision		Revision as of 12:51, 16 November 2010
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	Pharmacogenetics is the study of how a patient’s genetic variability can effect drug treatment. Genetic variation can have an effect of the outcome of drug treatment, for example via drug [[Metabolism\|metabolism]] <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>. Drug type and dosage are currently adapted to accommodate differences in patient age, liver and renal function<ref>Pharm. World Sci. 2010 Nov 4. ‘From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics’, Wilffert B, Swen J, Mulder H, Touw D, Maitland-Van der Zee AH, Deneer V; KNMP working group Pharmacogenetics, DOI 10.1007/s11096-010-9446-1</ref> and it is anticipated that pharmacogenetics can be used in the same way to maximise the efficacy of drug treatment as well as reduce the incidence of adverse drug responses.<ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>		Pharmacogenetics is the study of how a patient’s genetic variability can effect drug treatment. Genetic variation can have an effect of the outcome of drug treatment, for example via drug [[Metabolism\|metabolism]] <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>. Drug type and dosage are currently adapted to accommodate differences in patient age, liver and renal function<ref>Pharm. World Sci. 2010 Nov 4. ‘From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics’, Wilffert B, Swen J, Mulder H, Touw D, Maitland-Van der Zee AH, Deneer V; KNMP working group Pharmacogenetics, DOI 10.1007/s11096-010-9446-1</ref> and it is anticipated that pharmacogenetics can be used in the same way to maximise the efficacy of drug treatment as well as reduce the incidence of adverse drug responses.<ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>

	<br>Implementation of pharmacogenetics requires knowledge of the genotypic and phenotypic information relating to disease as well as an in-depth understanding of the mechanism of action of the drug.<ref>Becquemont L. Pharmacogenomics of adverse drug reactions: practical applications and perspectives. Pharmacogenomics. 2009;10(6):961–9.</ref> Once this information has been established it is possible to create a tailor-made drug treatment specific to the individual. <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>		<br>Implementation of pharmacogenetics requires knowledge of the genotypic and phenotypic information relating to disease as well as an in-depth understanding of the mechanism of action of the drug.<ref>Becquemont L. Pharmacogenomics of adverse drug reactions: practical applications and perspectives. Pharmacogenomics. 2009;10(6):961–9.</ref> Once this information has been established it is possible to create a tailor-made drug treatment specific to the individual. <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>

	<br>While cost is currently a major factor preventing wide scale use of pharmacogenetics, it is expected that in the future as the cost of [[DNA\|DNA]] sampling, [[DNA Sequencing\|DNA sequencing]] and analysis will decrease as technological advances in the field are made therefore reducing the costs associated with the implementation of pharmacogenetics on a wider scale.~~ &nbsp~~;		<br>While cost is currently a major factor preventing wide scale use of pharmacogenetics, it is expected that in the future as the cost of [[DNA\|DNA]] sampling, [[DNA Sequencing\|DNA sequencing]] and analysis will decrease as technological advances in the field are made therefore reducing the costs associated with the implementation of pharmacogenetics on a wider scale.<ref>Pharm. World Sci. 2010 Nov 4. ‘From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics’, Wilffert B, Swen J, Mulder H, Touw D, Maitland-Van der Zee AH, Deneer V; KNMP working group Pharmacogenetics, DOI 10.1007/s11096-010-9446-1</ref>

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090452844 at 12:50, 16 November 2010

2010-11-16T12:50:41Z

← Older revision		Revision as of 12:50, 16 November 2010
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	Pharmacogenetics is the study of how a patient’s genetic variability can effect drug treatment. Genetic variation can have an effect of the outcome of drug treatment, for example via drug [[Metabolism\|metabolism]] <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>. Drug type and dosage are currently adapted to accommodate differences in patient age, liver and renal function<ref>Pharm. World Sci. 2010 Nov 4. ‘From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics’, Wilffert B, Swen J, Mulder H, Touw D, Maitland-Van der Zee AH, Deneer V; KNMP working group Pharmacogenetics, DOI 10.1007/s11096-010-9446-1</ref> and it is anticipated that pharmacogenetics can be used in the same way to maximise the efficacy of drug treatment as well as reduce the incidence of adverse drug responses.<ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>		Pharmacogenetics is the study of how a patient’s genetic variability can effect drug treatment. Genetic variation can have an effect of the outcome of drug treatment, for example via drug [[Metabolism\|metabolism]] <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>. Drug type and dosage are currently adapted to accommodate differences in patient age, liver and renal function<ref>Pharm. World Sci. 2010 Nov 4. ‘From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics’, Wilffert B, Swen J, Mulder H, Touw D, Maitland-Van der Zee AH, Deneer V; KNMP working group Pharmacogenetics, DOI 10.1007/s11096-010-9446-1</ref> and it is anticipated that pharmacogenetics can be used in the same way to maximise the efficacy of drug treatment as well as reduce the incidence of adverse drug responses.<ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>

	<br>Implementation of pharmacogenetics requires knowledge of the genotypic and phenotypic information relating to disease as well as an in-depth understanding of the mechanism of action of the drug.<ref>Becquemont L. Pharmacogenomics of adverse drug reactions: practical applications and perspectives. Pharmacogenomics. 2009;10(6):961–9.</ref> Once this information has been established it is possible to create a tailor-made drug treatment specific to the individual.		<br>Implementation of pharmacogenetics requires knowledge of the genotypic and phenotypic information relating to disease as well as an in-depth understanding of the mechanism of action of the drug.<ref>Becquemont L. Pharmacogenomics of adverse drug reactions: practical applications and perspectives. Pharmacogenomics. 2009;10(6):961–9.</ref> Once this information has been established it is possible to create a tailor-made drug treatment specific to the individual. <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>

	<br>While cost is currently a major factor preventing wide scale use of pharmacogenetics, it is expected that in the future as the cost of [[DNA\|DNA]] sampling, [[DNA Sequencing\|DNA sequencing]] and analysis will decrease as technological advances in the field are made therefore reducing the costs associated with the implementation of pharmacogenetics on a wider scale.		<br>While cost is currently a major factor preventing wide scale use of pharmacogenetics, it is expected that in the future as the cost of [[DNA\|DNA]] sampling, [[DNA Sequencing\|DNA sequencing]] and analysis will decrease as technological advances in the field are made therefore reducing the costs associated with the implementation of pharmacogenetics on a wider scale.

090452844 at 12:49, 16 November 2010

2010-11-16T12:49:24Z

← Older revision		Revision as of 12:49, 16 November 2010
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	Pharmacogenetics is the study of how a patient’s genetic variability can effect drug treatment. Genetic variation can have an effect of the outcome of drug treatment, for example via drug [[Metabolism\|metabolism]] <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>. Drug type and dosage are currently adapted to accommodate differences in patient age, liver and renal function<ref>Pharm. World Sci. 2010 Nov 4. ‘From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics’, Wilffert B, Swen J, Mulder H, Touw D, Maitland-Van der Zee AH, Deneer V; KNMP working group Pharmacogenetics, DOI 10.1007/s11096-010-9446-1</ref> and it is anticipated that pharmacogenetics can be used in the same way to maximise the efficacy of drug treatment as well as reduce the incidence of adverse drug responses.<ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>		Pharmacogenetics is the study of how a patient’s genetic variability can effect drug treatment. Genetic variation can have an effect of the outcome of drug treatment, for example via drug [[Metabolism\|metabolism]] <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>. Drug type and dosage are currently adapted to accommodate differences in patient age, liver and renal function<ref>Pharm. World Sci. 2010 Nov 4. ‘From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics’, Wilffert B, Swen J, Mulder H, Touw D, Maitland-Van der Zee AH, Deneer V; KNMP working group Pharmacogenetics, DOI 10.1007/s11096-010-9446-1</ref> and it is anticipated that pharmacogenetics can be used in the same way to maximise the efficacy of drug treatment as well as reduce the incidence of adverse drug responses.<ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>

	<br>Implementation of pharmacogenetics requires knowledge of the genotypic and phenotypic information relating to disease as well as an in-depth understanding of the mechanism of action of the drug. Once this information has been established it is possible to create a tailor-made drug treatment specific to the individual.		<br>Implementation of pharmacogenetics requires knowledge of the genotypic and phenotypic information relating to disease as well as an in-depth understanding of the mechanism of action of the drug.<ref>Becquemont L. Pharmacogenomics of adverse drug reactions: practical applications and perspectives. Pharmacogenomics. 2009;10(6):961–9.</ref> Once this information has been established it is possible to create a tailor-made drug treatment specific to the individual.

	<br>While cost is currently a major factor preventing wide scale use of pharmacogenetics, it is expected that in the future as the cost of [[DNA\|DNA ~~sampling~~]], [[DNA Sequencing\|DNA sequencing]] and analysis will decrease as technological advances in the field are made therefore reducing the costs associated with the implementation of pharmacogenetics on a wider scale.		<br>While cost is currently a major factor preventing wide scale use of pharmacogenetics, it is expected that in the future as the cost of [[DNA\|DNA]] sampling, [[DNA Sequencing\|DNA sequencing]] and analysis will decrease as technological advances in the field are made therefore reducing the costs associated with the implementation of pharmacogenetics on a wider scale.

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090452844 at 12:47, 16 November 2010

2010-11-16T12:47:55Z

← Older revision		Revision as of 12:47, 16 November 2010
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	Pharmacogenetics is the study of how a patient’s genetic variability can effect drug treatment. Genetic variation can have an effect of the outcome of drug treatment, for example via drug [[Metabolism\|metabolism]] <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>. Drug type and dosage are currently adapted to accommodate differences in patient age, liver and renal function<ref>Pharm. World Sci. 2010 Nov 4. ‘From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics’, Wilffert B, Swen J, Mulder H, Touw D, Maitland-Van der Zee AH, Deneer V; KNMP working group Pharmacogenetics, DOI 10.1007/s11096-010-9446-1</ref> and it is anticipated that pharmacogenetics can be used in the same way to maximise the efficacy of drug treatment as well as reduce the incidence of adverse drug responses.		Pharmacogenetics is the study of how a patient’s genetic variability can effect drug treatment. Genetic variation can have an effect of the outcome of drug treatment, for example via drug [[Metabolism\|metabolism]] <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>. Drug type and dosage are currently adapted to accommodate differences in patient age, liver and renal function<ref>Pharm. World Sci. 2010 Nov 4. ‘From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics’, Wilffert B, Swen J, Mulder H, Touw D, Maitland-Van der Zee AH, Deneer V; KNMP working group Pharmacogenetics, DOI 10.1007/s11096-010-9446-1</ref> and it is anticipated that pharmacogenetics can be used in the same way to maximise the efficacy of drug treatment as well as reduce the incidence of adverse drug responses.<ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>

	<br>Implementation of pharmacogenetics requires knowledge of the genotypic and phenotypic information relating to disease as well as an in-depth understanding of the mechanism of action of the drug. Once this information has been established it is possible to create a tailor-made drug treatment specific to the individual.		<br>Implementation of pharmacogenetics requires knowledge of the genotypic and phenotypic information relating to disease as well as an in-depth understanding of the mechanism of action of the drug. Once this information has been established it is possible to create a tailor-made drug treatment specific to the individual.
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090452844 at 12:46, 16 November 2010

2010-11-16T12:46:45Z

← Older revision		Revision as of 12:46, 16 November 2010
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	<br>Implementation of pharmacogenetics requires knowledge of the genotypic and phenotypic information relating to disease as well as an in-depth understanding of the mechanism of action of the drug. Once this information has been established it is possible to create a tailor-made drug treatment specific to the individual.		<br>Implementation of pharmacogenetics requires knowledge of the genotypic and phenotypic information relating to disease as well as an in-depth understanding of the mechanism of action of the drug. Once this information has been established it is possible to create a tailor-made drug treatment specific to the individual.

	<br>While cost is currently a major factor preventing wide scale use of pharmacogenetics, it is expected that in the future as the cost of [[DNA\|DNA sampling]], [[DNA Sequencing\|DNA sequencing]] and analysis will decrease as technological advances in the field are made therefore reducing the costs associated with the implementation of pharmacogenetics on a wider scale.<ref>Pharm. World Sci. 2010 Nov 4. ‘From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics’, Wilffert B, Swen J, Mulder H, Touw D, Maitland-Van der Zee AH, Deneer V; KNMP working group Pharmacogenetics, DOI 10.1007/s11096-010-9446-1</ref>		<br>While cost is currently a major factor preventing wide scale use of pharmacogenetics, it is expected that in the future as the cost of [[DNA\|DNA sampling]], [[DNA Sequencing\|DNA sequencing]] and analysis will decrease as technological advances in the field are made therefore reducing the costs associated with the implementation of pharmacogenetics on a wider scale.

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090452844 at 12:46, 16 November 2010

2010-11-16T12:46:18Z

← Older revision		Revision as of 12:46, 16 November 2010
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	Pharmacogenetics is the study of how a patient’s genetic variability can effect drug treatment. Genetic variation can have an effect of the outcome of drug treatment, for example via drug [[Metabolism\|metabolism]] <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>. Drug type and dosage are currently adapted to accommodate differences in patient age, liver and renal function and it is anticipated that pharmacogenetics can be used in the same way to maximise the efficacy of drug treatment as well as reduce the incidence of adverse drug responses.		Pharmacogenetics is the study of how a patient’s genetic variability can effect drug treatment. Genetic variation can have an effect of the outcome of drug treatment, for example via drug [[Metabolism\|metabolism]] <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>. Drug type and dosage are currently adapted to accommodate differences in patient age, liver and renal function<ref>Pharm. World Sci. 2010 Nov 4. ‘From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics’, Wilffert B, Swen J, Mulder H, Touw D, Maitland-Van der Zee AH, Deneer V; KNMP working group Pharmacogenetics, DOI 10.1007/s11096-010-9446-1</ref> and it is anticipated that pharmacogenetics can be used in the same way to maximise the efficacy of drug treatment as well as reduce the incidence of adverse drug responses.

	<br>Implementation of pharmacogenetics requires knowledge of the genotypic and phenotypic information relating to disease as well as an in-depth understanding of the mechanism of action of the drug. Once this information has been established it is possible to create a tailor-made drug treatment specific to the individual.		<br>Implementation of pharmacogenetics requires knowledge of the genotypic and phenotypic information relating to disease as well as an in-depth understanding of the mechanism of action of the drug. Once this information has been established it is possible to create a tailor-made drug treatment specific to the individual.

	<br>While cost is currently a major factor preventing wide scale use of pharmacogenetics, it is expected that in the future as the cost of [[DNA\|DNA sampling]], [[DNA Sequencing\|DNA sequencing]] and analysis will decrease as technological advances in the field are made therefore reducing the costs associated with the implementation of pharmacogenetics on a wider scale.		<br>While cost is currently a major factor preventing wide scale use of pharmacogenetics, it is expected that in the future as the cost of [[DNA\|DNA sampling]], [[DNA Sequencing\|DNA sequencing]] and analysis will decrease as technological advances in the field are made therefore reducing the costs associated with the implementation of pharmacogenetics on a wider scale.<ref>Pharm. World Sci. 2010 Nov 4. ‘From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics’, Wilffert B, Swen J, Mulder H, Touw D, Maitland-Van der Zee AH, Deneer V; KNMP working group Pharmacogenetics, DOI 10.1007/s11096-010-9446-1</ref>

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	Pharmacogenetics is the study of how a patient’s genetic variability can effect drug treatment. Genetic variation can have an effect of the outcome of drug treatment, for example via drug [[Metabolism\|metabolism]]. Drug type and dosage are currently adapted to accommodate differences in patient age, liver and renal function and it is anticipated that pharmacogenetics can be used in the same way to maximise the efficacy of drug treatment as well as reduce the incidence of adverse drug responses.		Pharmacogenetics is the study of how a patient’s genetic variability can effect drug treatment. Genetic variation can have an effect of the outcome of drug treatment, for example via drug [[Metabolism\|metabolism]] <ref>KM, Johnson JA, et al. Pharmacogenomics: challenges and opportunities. Ann Intern Med. 2006;145(10):749–57. Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini</ref>. Drug type and dosage are currently adapted to accommodate differences in patient age, liver and renal function and it is anticipated that pharmacogenetics can be used in the same way to maximise the efficacy of drug treatment as well as reduce the incidence of adverse drug responses.

	<br>Implementation of pharmacogenetics requires knowledge of the genotypic and phenotypic information relating to disease as well as an in-depth understanding of the mechanism of action of the drug. Once this information has been established it is possible to create a tailor-made drug treatment specific to the individual.		<br>Implementation of pharmacogenetics requires knowledge of the genotypic and phenotypic information relating to disease as well as an in-depth understanding of the mechanism of action of the drug. Once this information has been established it is possible to create a tailor-made drug treatment specific to the individual.

	<br>While cost is currently a major factor preventing wide scale use of pharmacogenetics, it is expected that in the future as the cost of [[DNA\|DNA ]]~~sampling~~, [[~~DNA_Sequencing~~\|DNA sequencing]] and analysis will decrease as technological advances in the field are made therefore reducing the costs associated with the implementation of pharmacogenetics on a wider scale.  <br>		<br>While cost is currently a major factor preventing wide scale use of pharmacogenetics, it is expected that in the future as the cost of [[DNA\|DNA sampling]], [[DNA Sequencing\|DNA sequencing]] and analysis will decrease as technological advances in the field are made therefore reducing the costs associated with the implementation of pharmacogenetics on a wider scale.



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Pharmacogenetics is the study of how a patient’s genetic variability can effect drug treatment. Genetic variation can have an effect of the outcome of drug treatment, for example via drug [[Metabolism|metabolism]]. Drug type and dosage are currently adapted to accommodate differences in patient age, liver and renal function and it is anticipated that pharmacogenetics can be used in the same way to maximise the efficacy of drug treatment as well as reduce the incidence of adverse drug responses. 

 <br>Implementation of pharmacogenetics requires knowledge of the genotypic and phenotypic information relating to disease as well as an in-depth understanding of the mechanism of action of the drug. Once this information has been established it is possible to create a tailor-made drug treatment specific to the individual.

<br>While cost is currently a major factor preventing wide scale use of pharmacogenetics, it is expected that in the future as the cost of [[DNA|DNA ]]sampling, [[DNA_Sequencing|DNA sequencing]] and analysis will decrease as technological advances in the field are made therefore reducing the costs associated with the implementation of pharmacogenetics on a wider scale.  <br>