Poliomyelitis - Revision history

Nnjm2 at 13:16, 27 November 2018

2018-11-27T13:16:13Z

← Older revision		Revision as of 13:16, 27 November 2018
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	Polio is a highly contagious [[Picornavirus\|picornavirus]], though only a few patients develop any illness from the infection.		Polio is a highly contagious [[Picornavirus\|picornavirus]], though only a few patients develop any illness from the infection.

	~~'''''~~Spread~~''''': Droplet or faecal-oral.~~		=== Spread ===

	''~~'''Incubation: '''''7 days~~.		''Droplet or faecal-oral.

	'''''Signs:''''' ''Flu prodrome'' for 48h then ''pre-paralytic stage: ''T°, pulse, headache, vomiting, neck stiffness and unilateral tremor. In <50% this progresses to a ''paralytic stage'': myalgia, LMN signs ± respiratory failure. No sensory signs.		=== Incubation ===

	''~~'''Test:''''' CSF: WCC, polymorphs then [[Lymphocytes\|lymphocytes]], otherwise normal; paired [[Sera\|sera]] (14~~ days ~~apart); throat swab and stool culture identify [[Virus\|virus]]~~.		''7 days.

	'''''~~Natural history~~: '''''<10% of those with paralysis die. There maybe delayed progression of paralysis ('''''post-polio syndrome''''', PPS). Risk of severe paralysis in adults; pregnant; [[Muscle\|muscle]] fatigue/trauma during incubation period. '''''PPS''''' causes fatigue, weakness, [[Myalgia\|myalgia]], and worsening function, not necessarily at sites originally affected (advise enough exercise to prevent wasting but no so at sites originally affected (advise enough exersice to prevent wasting but not so much as to weaknessin aldready damaged muscles)). No drug works.		=== Signs ===

			''''Flu prodrome'' for 48h then ''pre-paralytic stage: ''T°, pulse, headache, vomiting, neck stiffness and unilateral tremor. In <50% this progresses to a ''paralytic stage'': myalgia, LMN signs ± respiratory failure. No sensory signs.

			=== Test: ===

			CSF: WCC, polymorphs then [[Lymphocytes\|lymphocytes]], otherwise normal; paired [[Sera\|sera]] (14 days apart); throat swab and stool culture identify [[Virus\|virus]].

			=== Natural history:  ===

			''<10% of those with paralysis die. There maybe delayed progression of paralysis ('''''post-polio syndrome''''', PPS). Risk of severe paralysis in adults; pregnant; [[Muscle\|muscle]] fatigue/trauma during incubation period. '''''PPS''''' causes fatigue, weakness, [[Myalgia\|myalgia]], and worsening function, not necessarily at sites originally affected (advise enough exercise to prevent wasting but no so at sites originally affected (advise enough exersice to prevent wasting but not so much as to weaknessin aldready damaged muscles)). No drug works<ref>www.oup.com/uk/ohcm9refs</ref>.

	'''''Vaccine:''''' p391		'''''Vaccine:''''' p391

	~~'''''Reference:'''''~~		=== References ===

	~~<ref>www.oup.com/uk/ohcm9refs</ref>~~<references /~~><br~~>		<references />

180658150 at 12:49, 27 November 2018

2018-11-27T12:49:29Z

← Older revision		Revision as of 12:49, 27 November 2018
Line 1:		Line 1:
	Polio is a highly contagious [[~~picornavirus~~\|picornavirus]], though only a few patients develop any illness from the infection.		Polio is a highly contagious [[Picornavirus\|picornavirus]], though only a few patients develop any illness from the infection.

	'''''Spread''''': Droplet or faecal-oral.		'''''Spread''''': Droplet or faecal-oral.
Line 7:		Line 7:
	'''''Signs:''''' ''Flu prodrome'' for 48h then ''pre-paralytic stage: ''T°, pulse, headache, vomiting, neck stiffness and unilateral tremor. In <50% this progresses to a ''paralytic stage'': myalgia, LMN signs ± respiratory failure. No sensory signs.		'''''Signs:''''' ''Flu prodrome'' for 48h then ''pre-paralytic stage: ''T°, pulse, headache, vomiting, neck stiffness and unilateral tremor. In <50% this progresses to a ''paralytic stage'': myalgia, LMN signs ± respiratory failure. No sensory signs.

	'''''Test:''''' CSF: WCC, polymorphs then [[~~lymphocytes~~\|lymphocytes]], otherwise normal; paired [[~~sera~~\|sera]] (14 days apart); throat swab and stool culture identify [[~~virus~~\|virus]].		'''''Test:''''' CSF: WCC, polymorphs then [[Lymphocytes\|lymphocytes]], otherwise normal; paired [[Sera\|sera]] (14 days apart); throat swab and stool culture identify [[Virus\|virus]].

	'''''Natural history: '''''<10% of those with paralysis die. There maybe delayed progression of paralysis ('''''post-polio syndrome''''', PPS). Risk of severe paralysis in adults; pregnant; [[~~muscle~~\|muscle]] fatigue/trauma during incubation period. '''''PPS''''' causes fatigue, weakness, [[~~myalgia~~\|myalgia]], and worsening function, not necessarily at sites originally affected (advise enough exercise to prevent wasting but no so at sites originally affected (advise enough exersice to prevent wasting but not so much as to weaknessin aldready damaged muscles)). No drug works.		'''''Natural history: '''''<10% of those with paralysis die. There maybe delayed progression of paralysis ('''''post-polio syndrome''''', PPS). Risk of severe paralysis in adults; pregnant; [[Muscle\|muscle]] fatigue/trauma during incubation period. '''''PPS''''' causes fatigue, weakness, [[Myalgia\|myalgia]], and worsening function, not necessarily at sites originally affected (advise enough exercise to prevent wasting but no so at sites originally affected (advise enough exersice to prevent wasting but not so much as to weaknessin aldready damaged muscles)). No drug works.

	'''''Vaccine:''''' p391		'''''Vaccine:''''' p391

			'''''Reference:'''''

			<ref>www.oup.com/uk/ohcm9refs</ref><references /><br>

Nnjm2: Cleaned up the text. Not one link, so I added some. Page layout could be improved. Added a lot of spaces. Needs refs. Page doesn't read well.

2018-11-27T11:08:25Z

Cleaned up the text. Not one link, so I added some. Page layout could be improved. Added a lot of spaces. Needs refs. Page doesn't read well.

← Older revision		Revision as of 11:08, 27 November 2018
Line 1:		Line 1:
	Polio is a highly contagious picornavirus,though only a few patients develop any illness from the infection.		Polio is a highly contagious [[picornavirus\|picornavirus]], though only a few patients develop any illness from the infection.

	'''''Spread''''': Droplet or faecal-oral.		'''''Spread''''': Droplet or faecal-oral.

	'''''Incubation:'''''7 days.		'''''Incubation: '''''7 days.

	'''''Signs:''''' ''Flu prodrome'' for 48h then ''pre-paralytic stage:''T°,pulse,headache,vomiting,neck stiffness and unilateral tremor. In <50% this progresses to a ''paralytic stage'':myalgia,LMN signs~~ ~~± respiratory failure.No sensory signs.		'''''Signs:''''' ''Flu prodrome'' for 48h then ''pre-paralytic stage: ''T°, pulse, headache, vomiting, neck stiffness and unilateral tremor. In <50% this progresses to a ''paralytic stage'': myalgia, LMN signs ± respiratory failure. No sensory signs.

	'''''Test:''''' CSF:WCC,polymorphs then lymphocytes,otherwise normal;paired sera(14 days apart);throat swab and stool culture identify virus.		'''''Test:''''' CSF: WCC, polymorphs then [[lymphocytes\|lymphocytes]], otherwise normal; paired [[sera\|sera]] (14 days apart); throat swab and stool culture identify [[virus\|virus]].

	'''''Natural history:'''''<10% of those with paralysis die.There maybe delayed progression of paralysis('''''post-polio syndrome''''',PPS).Risk of severe ~~paralysisif Adults~~;pregnant;muscle fatigue/trauma during incubation period.'''''PPS''''' causes fatigue,weakness,myalgia, and worsening function,not necessarily at sites originally affected(advise enough exercise to prevent wasting but no so at sites originally affected(advise enough exersice to prevent wasting but not so much as to weaknessin aldready damaged muscles).No drug works.		'''''Natural history: '''''<10% of those with paralysis die. There maybe delayed progression of paralysis ('''''post-polio syndrome''''', PPS). Risk of severe paralysis in adults; pregnant; [[muscle\|muscle]] fatigue/trauma during incubation period. '''''PPS''''' causes fatigue, weakness, [[myalgia\|myalgia]], and worsening function, not necessarily at sites originally affected (advise enough exercise to prevent wasting but no so at sites originally affected (advise enough exersice to prevent wasting but not so much as to weaknessin aldready damaged muscles)). No drug works.

	'''''Vaccine:''''' p391		'''''Vaccine:''''' p391

180658150 at 07:59, 27 November 2018

2018-11-27T07:59:04Z

← Older revision		Revision as of 07:59, 27 November 2018
Line 1:		Line 1:
	Polio is a highly contagious picornavirus,though only a few patients develop any illness from the infection.'''''Spread''''': Droplet or faecal-oral.'''''Incubation:'''''7 days.'''''Signs:''''' ''Flu prodrome'' for 48h then ''pre-paralytic stage:''T°,pulse,headache,vomiting,neck stiffness and unilateral tremor. In <50% this progresses to a ''paralytic stage'':myalgia,LMN signs ± respiratory failure.No sensory signs.'''''Test:''''' CSF:WCC,polymorphs then lymphocytes,otherwise normal;paired sera(14 days apart);throat swab and stool culture identify virus.'''''Natural history:'''''<10% of those with paralysis die.There maybe delayed progression of paralysis('''''post-polio syndrome''''',PPS).Risk of severe paralysisif Adults;pregnant;muscle fatigue/trauma during incubation period.'''''PPS''''' causes fatigue,weakness,myalgia, and worsening function,not necessarily at sites originally affected(advise enough exercise to prevent wasting but no so at sites originally affected(advise enough exersice to prevent wasting but not so much as to weaknessin aldready damaged muscles).No drug works. '''''Vaccine:''''' p391		Polio is a highly contagious picornavirus,though only a few patients develop any illness from the infection.

			'''''Spread''''': Droplet or faecal-oral.

			'''''Incubation:'''''7 days.

			'''''Signs:''''' ''Flu prodrome'' for 48h then ''pre-paralytic stage:''T°,pulse,headache,vomiting,neck stiffness and unilateral tremor. In <50% this progresses to a ''paralytic stage'':myalgia,LMN signs ± respiratory failure.No sensory signs.

			'''''Test:''''' CSF:WCC,polymorphs then lymphocytes,otherwise normal;paired sera(14 days apart);throat swab and stool culture identify virus.

			'''''Natural history:'''''<10% of those with paralysis die.There maybe delayed progression of paralysis('''''post-polio syndrome''''',PPS).Risk of severe paralysisif Adults;pregnant;muscle fatigue/trauma during incubation period.'''''PPS''''' causes fatigue,weakness,myalgia, and worsening function,not necessarily at sites originally affected(advise enough exercise to prevent wasting but no so at sites originally affected(advise enough exersice to prevent wasting but not so much as to weaknessin aldready damaged muscles).No drug works.

			'''''Vaccine:''''' p391

180658150: Created page with "Polio is a highly contagious picornavirus,though only a few patients develop any illness from the infection.'''''Spread''''': Droplet or faecal-oral.'''''Incubation:'''''7 days.'..."

2018-11-27T07:55:30Z

Created page with "Polio is a highly contagious picornavirus,though only a few patients develop any illness from the infection.'''''Spread''''': Droplet or faecal-oral.'''''Incubation:'''''7 days.'..."

New page

Polio is a highly contagious picornavirus,though only a few patients develop any illness from the infection.'''''Spread''''': Droplet or faecal-oral.'''''Incubation:'''''7 days.'''''Signs:''''' ''Flu prodrome'' for 48h then ''pre-paralytic stage:''T°,pulse,headache,vomiting,neck stiffness and unilateral tremor. In <50% this progresses to a ''paralytic stage'':myalgia,LMN signs ± respiratory failure.No sensory signs.'''''Test:''''' CSF:WCC,polymorphs then lymphocytes,otherwise normal;paired sera(14 days apart);throat swab and stool culture identify virus.'''''Natural history:'''''<10% of those with paralysis die.There maybe delayed progression of paralysis('''''post-polio syndrome''''',PPS).Risk of severe paralysisif Adults;pregnant;muscle fatigue/trauma during incubation period.'''''PPS''''' causes fatigue,weakness,myalgia, and worsening function,not necessarily at sites originally affected(advise enough exercise to prevent wasting but no so at sites originally affected(advise enough exersice to prevent wasting but not so much as to weaknessin aldready damaged muscles).No drug works. '''''Vaccine:''''' p391