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	<id>https://teaching.ncl.ac.uk/bms/wiki//index.php?action=history&amp;feed=atom&amp;title=Purines_and_Pyrimidines</id>
	<title>Purines and Pyrimidines - Revision history</title>
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	<updated>2026-04-10T11:34:00Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
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	<entry>
		<id>https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Purines_and_Pyrimidines&amp;diff=20324&amp;oldid=prev</id>
		<title>Nnjm2 at 09:52, 6 December 2017</title>
		<link rel="alternate" type="text/html" href="https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Purines_and_Pyrimidines&amp;diff=20324&amp;oldid=prev"/>
		<updated>2017-12-06T09:52:53Z</updated>

		<summary type="html">&lt;p&gt;&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
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				&lt;col class=&quot;diff-content&quot; /&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 09:52, 6 December 2017&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l1&quot;&gt;Line 1:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Line 1:&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Purines|Purines]] and [[Pyrimidines|pyrimidines]] are the two distinct [[&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Nitrogenous_base&lt;/del&gt;|nitrogenous]] nucleotide bases which form the five nucleobases present in&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;amp;nbsp;&lt;/del&gt;[[DNA|DNA]] and [[RNA|RNA]]&amp;lt;ref name=&quot;[1]&quot;&amp;gt;Berg JM, Tymoczko JL, Gatto GJ Jr, Stryer L. Biochemistry. W. H. Freeman; 2015.&amp;lt;/ref&amp;gt;. Pyrimidine bases are [[&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;heterocyclic&lt;/del&gt;|heterocyclic]] compounds which consist of a single carbon ring containing two nitrogen atoms, whereas purine bases consist of two carbon rings (a pyrimidine ring fused to an [[Imidazole|imidazole]] ring) containing a greater number of nitrogen atoms, so their structures provide distinct differences splitting nucleobases into two types. There are two types of Purines: [[Adenine|Adenine]] and [[Guanine|Guanine]], and three types of Pyrimidines: [[Cytosine|Cytosine]], [[Thymine|Thymine]]&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;amp;nbsp;&lt;/del&gt;(which is only used in DNA, as its substituted by Uracil in RNA during [[DNA transcription|transcription]])&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;amp;nbsp;&lt;/del&gt;and [[Uracil|Uracil]] (which is only present in types of&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;amp;nbsp;&lt;/del&gt;[[RNA Polymerase II|RNA]], such as&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;amp;nbsp;&lt;/del&gt;[[MRNA|mRNA]] and [[TRNA|tRNA]]&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;amp;nbsp;&lt;/del&gt;substituting Thymine)&amp;lt;ref name=&quot;[2]&quot;&amp;gt;Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, et al. Molecular Biology of the Cell. Garland Publishing; 2014.&amp;lt;/ref&amp;gt;.&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;amp;nbsp; &lt;/del&gt;&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Purines|Purines]] and [[Pyrimidines|pyrimidines]] are the two distinct [[&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Nitrogenous base&lt;/ins&gt;|nitrogenous]] nucleotide bases which form the five nucleobases present in [[DNA|DNA]] and [[RNA|RNA]]&amp;lt;ref name=&quot;[1]&quot;&amp;gt;Berg JM, Tymoczko JL, Gatto GJ Jr, Stryer L. Biochemistry. W. H. Freeman; 2015.&amp;lt;/ref&amp;gt;. Pyrimidine bases are [[&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Heterocyclic&lt;/ins&gt;|heterocyclic]] compounds which consist of a single carbon ring containing two nitrogen atoms, whereas purine bases consist of two carbon rings (a pyrimidine ring fused to an [[Imidazole|imidazole]] ring) containing a greater number of nitrogen atoms, so their structures provide distinct differences splitting nucleobases into two types. There are two types of Purines: [[Adenine|Adenine]] and [[Guanine|Guanine]], and three types of Pyrimidines: [[Cytosine|Cytosine]], [[Thymine|Thymine]] (which is only used in DNA, as its substituted by Uracil in RNA during [[DNA transcription|transcription]]) and [[Uracil|Uracil]] (which is only present in types of [[RNA Polymerase II|RNA]], such as [[MRNA|mRNA]] and [[TRNA|tRNA]] substituting Thymine)&amp;lt;ref name=&quot;[2]&quot;&amp;gt;Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, et al. Molecular Biology of the Cell. Garland Publishing; 2014.&amp;lt;/ref&amp;gt;.  &lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&#039;&#039;&#039;&lt;/del&gt;Base pairing&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&#039;&#039;&#039; &lt;/del&gt;&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;=== &lt;/ins&gt;Base pairing &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;===&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;---&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;-&lt;/del&gt;&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Purines always bond with pyrimidines via [[Hydrogen bonds|hydrogen bonds]] following the [[Chargaff&#039;s Rules|Chargaff rule]] in [[DsDNA|dsDNA]], more specifically each bond follows [[Watson&lt;/ins&gt;-&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Crick base pairing|Watson&lt;/ins&gt;-&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Crick base pairing]] rules&amp;lt;ref name=&quot;[3]&quot;&amp;gt;Griffiths AJF, Miller JH, Suzuki DT, Lewontin RC, Gelbart WM. Structure of DNA. 2000 [cited 2017 Dec 6]; Available from: https://www.ncbi.nlm.nih.gov/books/NBK21786/&amp;lt;/ref&amp;gt;. Therefore adenine specifically bonds to thymine forming two hydrogen bonds, whereas guanine forms three [[Hydrogen bonds|hydrogen bonds]] with Cytosine. During transcription and [[Translation|translation]] as thymine is substituted by uracil in RNA (mRNA and tRNA), uracil forms two hydrogen bonds with adenine so the pyrimidine&lt;/ins&gt;-&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;purine base pairing is maintained. &lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Purines always bond with pyrimidines via [[Hydrogen bonds|hydrogen bonds]]&amp;amp;nbsp;following the [[Chargaff&#039;s Rules|Chargaff rule]]&amp;amp;nbsp;in [[dsDNA|dsDNA]], more specifically each bond follows [[Watson-Crick base pairing|Watson-Crick base pairing]] rules&amp;lt;ref name&lt;/del&gt;=&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&quot;[3]&quot;&amp;gt;Griffiths AJF, Miller JH, Suzuki DT, Lewontin RC, Gelbart WM. Structure of DNA. 2000 [cited 2017 Dec 6]; Available from: https://www.ncbi.nlm.nih.gov/books/NBK21786/&amp;lt;/ref&amp;gt;. Therefore adenine specifically bonds to thymine forming two hydrogen bonds, whereas guanine forms three [[Hydrogen bonds|hydrogen bonds]] with Cytosine. During transcription and [[Translation|translation]] as thymine is substituted by uracil in RNA (mRNA and tRNA), uracil forms two hydrogen bonds with adenine so the pyrimidine-purine base pairing is maintained.&amp;amp;nbsp; &lt;/del&gt;&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;=&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;== References ===&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;lt;br&amp;gt; &lt;/del&gt;&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&amp;lt;references /&amp;gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt; &lt;/div&gt;&lt;/td&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-added&quot;&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;lt;references /&amp;gt;&amp;lt;references /&amp;gt;&lt;/del&gt;&amp;lt;references /&amp;gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-added&quot;&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;/table&gt;</summary>
		<author><name>Nnjm2</name></author>
	</entry>
	<entry>
		<id>https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Purines_and_Pyrimidines&amp;diff=20234&amp;oldid=prev</id>
		<title>170726832 at 05:21, 6 December 2017</title>
		<link rel="alternate" type="text/html" href="https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Purines_and_Pyrimidines&amp;diff=20234&amp;oldid=prev"/>
		<updated>2017-12-06T05:21:09Z</updated>

		<summary type="html">&lt;p&gt;&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 05:21, 6 December 2017&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l1&quot;&gt;Line 1:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Line 1:&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Purines|Purines]] and [[Pyrimidines|pyrimidines]] are the two distinct nitrogenous nucleotide bases which form the five nucleobases present in&amp;amp;nbsp;[[DNA|DNA]] and RNA&amp;lt;ref name=&quot;[1]&quot;&amp;gt;Berg JM, Tymoczko JL, Gatto GJ Jr, Stryer L. Biochemistry. W. H. Freeman; 2015.&amp;lt;/ref&amp;gt;. Pyrimidine bases are heterocyclic compounds which consist of a single carbon ring containing two nitrogen atoms, whereas purine bases consist of two carbon rings (a pyrimidine ring fused to an [[Imidazole|imidazole]] ring) containing a greater number of nitrogen atoms, so their structures provide distinct differences splitting nucleobases into two types. There are two types of Purines: [[Adenine|Adenine]] and [[Guanine|Guanine]], and three types of Pyrimidines: [[Cytosine|Cytosine]], [[Thymine|Thymine]]&amp;amp;nbsp;(which is only used in DNA, as its substituted by Uracil in RNA during [[DNA transcription|transcription]])&amp;amp;nbsp;and [[Uracil|Uracil]] (which is only present in types of&amp;amp;nbsp;[[RNA Polymerase II|RNA]], such as&amp;amp;nbsp;[[MRNA|mRNA]] and [[TRNA|tRNA]]&amp;amp;nbsp;substituting Thymine)&amp;lt;ref name=&quot;[2]&quot;&amp;gt;Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, et al. Molecular Biology of the Cell. Garland Publishing; 2014.&amp;lt;/ref&amp;gt;.&amp;amp;nbsp;  &lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Purines|Purines]] and [[Pyrimidines|pyrimidines]] are the two distinct &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[Nitrogenous_base|&lt;/ins&gt;nitrogenous&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;]] &lt;/ins&gt;nucleotide bases which form the five nucleobases present in&amp;amp;nbsp;[[DNA|DNA]] and &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[RNA|&lt;/ins&gt;RNA&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;]]&lt;/ins&gt;&amp;lt;ref name=&quot;[1]&quot;&amp;gt;Berg JM, Tymoczko JL, Gatto GJ Jr, Stryer L. Biochemistry. W. H. Freeman; 2015.&amp;lt;/ref&amp;gt;. Pyrimidine bases are &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[heterocyclic|&lt;/ins&gt;heterocyclic&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;]] &lt;/ins&gt;compounds which consist of a single carbon ring containing two nitrogen atoms, whereas purine bases consist of two carbon rings (a pyrimidine ring fused to an [[Imidazole|imidazole]] ring) containing a greater number of nitrogen atoms, so their structures provide distinct differences splitting nucleobases into two types. There are two types of Purines: [[Adenine|Adenine]] and [[Guanine|Guanine]], and three types of Pyrimidines: [[Cytosine|Cytosine]], [[Thymine|Thymine]]&amp;amp;nbsp;(which is only used in DNA, as its substituted by Uracil in RNA during [[DNA transcription|transcription]])&amp;amp;nbsp;and [[Uracil|Uracil]] (which is only present in types of&amp;amp;nbsp;[[RNA Polymerase II|RNA]], such as&amp;amp;nbsp;[[MRNA|mRNA]] and [[TRNA|tRNA]]&amp;amp;nbsp;substituting Thymine)&amp;lt;ref name=&quot;[2]&quot;&amp;gt;Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, et al. Molecular Biology of the Cell. Garland Publishing; 2014.&amp;lt;/ref&amp;gt;.&amp;amp;nbsp;  &lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&amp;#039;&amp;#039;&amp;#039;Base pairing&amp;#039;&amp;#039;&amp;#039;  &lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&amp;#039;&amp;#039;&amp;#039;Base pairing&amp;#039;&amp;#039;&amp;#039;  &lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l5&quot;&gt;Line 5:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Line 5:&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;----&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;----&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;Purines always bond with pyrimidines via [[Hydrogen bonds|hydrogen bonds]]&amp;amp;nbsp;following the [[Chargaff&#039;s Rules|Chargaff rule]]&amp;amp;nbsp;in dsDNA, more specifically each bond follows [[Watson-Crick base pairing|Watson-Crick base pairing]] rules&amp;lt;ref name=&quot;[3]&quot;&amp;gt;Griffiths AJF, Miller JH, Suzuki DT, Lewontin RC, Gelbart WM. Structure of DNA. 2000 [cited 2017 Dec 6]; Available from: https://www.ncbi.nlm.nih.gov/books/NBK21786/&amp;lt;/ref&amp;gt;. Therefore adenine specifically bonds to thymine forming two hydrogen bonds, whereas guanine forms three [[Hydrogen bonds|hydrogen bonds]] with Cytosine. During transcription and [[Translation|translation]] as thymine is substituted by uracil in RNA (mRNA and tRNA), uracil forms two hydrogen bonds with adenine so the pyrimidine-purine base pairing is maintained.&amp;amp;nbsp;  &lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;Purines always bond with pyrimidines via [[Hydrogen bonds|hydrogen bonds]]&amp;amp;nbsp;following the [[Chargaff&#039;s Rules|Chargaff rule]]&amp;amp;nbsp;in &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[&lt;/ins&gt;dsDNA&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;|dsDNA]]&lt;/ins&gt;, more specifically each bond follows [[Watson-Crick base pairing|Watson-Crick base pairing]] rules&amp;lt;ref name=&quot;[3]&quot;&amp;gt;Griffiths AJF, Miller JH, Suzuki DT, Lewontin RC, Gelbart WM. Structure of DNA. 2000 [cited 2017 Dec 6]; Available from: https://www.ncbi.nlm.nih.gov/books/NBK21786/&amp;lt;/ref&amp;gt;. Therefore adenine specifically bonds to thymine forming two hydrogen bonds, whereas guanine forms three [[Hydrogen bonds|hydrogen bonds]] with Cytosine. During transcription and [[Translation|translation]] as thymine is substituted by uracil in RNA (mRNA and tRNA), uracil forms two hydrogen bonds with adenine so the pyrimidine-purine base pairing is maintained.&amp;amp;nbsp;  &lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&amp;lt;br&amp;gt;  &lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&amp;lt;br&amp;gt;  &lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&amp;lt;references /&amp;gt;&amp;lt;references /&amp;gt;&amp;lt;references /&amp;gt;&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&amp;lt;references /&amp;gt;&amp;lt;references /&amp;gt;&amp;lt;references /&amp;gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;/table&gt;</summary>
		<author><name>170726832</name></author>
	</entry>
	<entry>
		<id>https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Purines_and_Pyrimidines&amp;diff=20233&amp;oldid=prev</id>
		<title>170726832: I added additional content to clearly identify the difference between pyrimidine and purine bases. Moreover I have backed up my content through research, and have specified my references for the information.</title>
		<link rel="alternate" type="text/html" href="https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Purines_and_Pyrimidines&amp;diff=20233&amp;oldid=prev"/>
		<updated>2017-12-06T05:17:50Z</updated>

		<summary type="html">&lt;p&gt;I added additional content to clearly identify the difference between pyrimidine and purine bases. Moreover I have backed up my content through research, and have specified my references for the information.&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 05:17, 6 December 2017&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l1&quot;&gt;Line 1:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Line 1:&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Purines|Purines]] and [[Pyrimidines|pyrimidines]] are the two &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;building blocks &lt;/del&gt;of [[&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Nucleic acids&lt;/del&gt;|&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;nucleic acids&lt;/del&gt;]]. There are two types of &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;purines&lt;/del&gt;: [[Adenine|Adenine]] and [[Guanine|Guanine]], and three &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;different &lt;/del&gt;types of &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;pyrimidines&lt;/del&gt;: [[Cytosine|&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;cytosine&lt;/del&gt;]], [[Thymine|&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;thymine&lt;/del&gt;]] and [[Uracil|&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;uracil&lt;/del&gt;]] (which is only &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;used &lt;/del&gt;in [[RNA Polymerase II|RNA]],&amp;amp;nbsp;[[MRNA|mRNA]] and [[TRNA|tRNA]]). Purines always bond with pyrimidines via [[&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Hydrogen_bonds&lt;/del&gt;|hydrogen bonds]]. &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;The purine Adenine forms &lt;/del&gt;two hydrogen bonds &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;with the pyrimidine Thymine and the purine Guanine &lt;/del&gt;forms three [[Hydrogen bonds|hydrogen bonds]] with &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;the pyramidine &lt;/del&gt;Cytosine. &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;In RNA, mRNA and tRNA, during [[Transcription|&lt;/del&gt;transcription&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;]] &lt;/del&gt;and [[Translation|translation]]&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;, Thymine &lt;/del&gt;is substituted &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;with Uracil meaning Adenine bonds with Uracil instead&lt;/del&gt;, &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;forming &lt;/del&gt;two hydrogen bonds.&amp;amp;nbsp;&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Purines|Purines]] and [[Pyrimidines|pyrimidines]] are the two &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;distinct nitrogenous nucleotide bases which form the five nucleobases present in&amp;amp;nbsp;[[DNA|DNA]] and RNA&amp;lt;ref name=&quot;[1]&quot;&amp;gt;Berg JM, Tymoczko JL, Gatto GJ Jr, Stryer L. Biochemistry. W. H. Freeman; 2015.&amp;lt;/ref&amp;gt;. Pyrimidine bases are heterocyclic compounds which consist of a single carbon ring containing two nitrogen atoms, whereas purine bases consist &lt;/ins&gt;of &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;two carbon rings (a pyrimidine ring fused to an &lt;/ins&gt;[[&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Imidazole&lt;/ins&gt;|&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;imidazole&lt;/ins&gt;]] &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;ring) containing a greater number of nitrogen atoms, so their structures provide distinct differences splitting nucleobases into two types&lt;/ins&gt;. There are two types of &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Purines&lt;/ins&gt;: [[Adenine|Adenine]] and [[Guanine|Guanine]], and three types of &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Pyrimidines&lt;/ins&gt;: [[Cytosine|&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Cytosine&lt;/ins&gt;]], [[Thymine|&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Thymine]]&amp;amp;nbsp;(which is only used in DNA, as its substituted by Uracil in RNA during [[DNA transcription|transcription&lt;/ins&gt;]]&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;)&amp;amp;nbsp;&lt;/ins&gt;and [[Uracil|&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Uracil&lt;/ins&gt;]] (which is only &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;present &lt;/ins&gt;in &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;types of&amp;amp;nbsp;&lt;/ins&gt;[[RNA Polymerase II|RNA]], &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;such as&lt;/ins&gt;&amp;amp;nbsp;[[MRNA|mRNA]] and [[TRNA|tRNA]]&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;amp;nbsp;substituting Thymine&lt;/ins&gt;)&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;lt;ref name=&quot;[2]&quot;&amp;gt;Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, et al. Molecular Biology of the Cell. Garland Publishing; 2014.&amp;lt;/ref&amp;gt;&lt;/ins&gt;.&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;amp;nbsp; &lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-deleted&quot;&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt; &lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-deleted&quot;&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&#039;&#039;&#039;Base pairing&#039;&#039;&#039; &lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-deleted&quot;&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt; &lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-deleted&quot;&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;----&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-deleted&quot;&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt; &lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-deleted&quot;&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;Purines always bond with pyrimidines via [[&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Hydrogen bonds&lt;/ins&gt;|hydrogen bonds]]&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;amp;nbsp;following the [[Chargaff&#039;s Rules|Chargaff rule]]&amp;amp;nbsp;in dsDNA, more specifically each bond follows [[Watson-Crick base pairing|Watson-Crick base pairing]] rules&amp;lt;ref name=&quot;[3]&quot;&amp;gt;Griffiths AJF, Miller JH, Suzuki DT, Lewontin RC, Gelbart WM. Structure of DNA. 2000 [cited 2017 Dec 6]; Available from: https://www.ncbi.nlm.nih.gov/books/NBK21786/&amp;lt;/ref&amp;gt;&lt;/ins&gt;. &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Therefore adenine specifically bonds to thymine forming &lt;/ins&gt;two hydrogen bonds&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;, whereas guanine &lt;/ins&gt;forms three [[Hydrogen bonds|hydrogen bonds]] with Cytosine. &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;During &lt;/ins&gt;transcription and [[Translation|translation]] &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;as thymine &lt;/ins&gt;is substituted &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;by uracil in RNA (mRNA and tRNA)&lt;/ins&gt;, &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;uracil forms &lt;/ins&gt;two hydrogen bonds &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;with adenine so the pyrimidine-purine base pairing is maintained&lt;/ins&gt;.&amp;amp;nbsp;  &lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-deleted&quot;&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt; &lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-deleted&quot;&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;lt;br&amp;gt; &lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-deleted&quot;&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt; &lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-deleted&quot;&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;lt;references /&amp;gt;&amp;lt;references /&amp;gt;&amp;lt;references /&amp;gt;&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;/table&gt;</summary>
		<author><name>170726832</name></author>
	</entry>
	<entry>
		<id>https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Purines_and_Pyrimidines&amp;diff=16089&amp;oldid=prev</id>
		<title>Nnjm2: Added some more links.</title>
		<link rel="alternate" type="text/html" href="https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Purines_and_Pyrimidines&amp;diff=16089&amp;oldid=prev"/>
		<updated>2016-11-17T20:35:41Z</updated>

		<summary type="html">&lt;p&gt;Added some more links.&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
				&lt;col class=&quot;diff-marker&quot; /&gt;
				&lt;col class=&quot;diff-content&quot; /&gt;
				&lt;col class=&quot;diff-marker&quot; /&gt;
				&lt;col class=&quot;diff-content&quot; /&gt;
				&lt;tr class=&quot;diff-title&quot; lang=&quot;en&quot;&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 20:35, 17 November 2016&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l1&quot;&gt;Line 1:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Line 1:&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Purines|Purines]] and [[Pyrimidines|pyrimidines]] are the two building blocks of [[Nucleic acids|nucleic acids]]. There are two types of purines: [[Adenine|Adenine]] and [[Guanine|Guanine]], and three different types of pyrimidines: [[Cytosine|cytosine]], [[Thymine|thymine]] and [[Uracil|uracil]] (which is only used in RNA,&amp;amp;nbsp;[[MRNA|mRNA]] and [[TRNA|tRNA]]). Purines always bond with pyrimidines via hydrogen bonds. The purine Adenine forms two hydrogen bonds with the pyrimidine Thymine and the purine Guanine forms three [[Hydrogen bonds|hydrogen bonds]] with the pyramidine Cytosine. In RNA, mRNA and tRNA, during [[Transcription|transcription]] and [[Translation|translation]], Thymine is substituted with Uracil meaning Adenine bonds with Uracil instead, forming two hydrogen bonds.&amp;amp;nbsp;&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Purines|Purines]] and [[Pyrimidines|pyrimidines]] are the two building blocks of [[Nucleic acids|nucleic acids]]. There are two types of purines: [[Adenine|Adenine]] and [[Guanine|Guanine]], and three different types of pyrimidines: [[Cytosine|cytosine]], [[Thymine|thymine]] and [[Uracil|uracil]] (which is only used in &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[RNA Polymerase II|&lt;/ins&gt;RNA&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;]]&lt;/ins&gt;,&amp;amp;nbsp;[[MRNA|mRNA]] and [[TRNA|tRNA]]). Purines always bond with pyrimidines via &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[Hydrogen_bonds|&lt;/ins&gt;hydrogen bonds&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;]]&lt;/ins&gt;. The purine Adenine forms two hydrogen bonds with the pyrimidine Thymine and the purine Guanine forms three [[Hydrogen bonds|hydrogen bonds]] with the pyramidine Cytosine. In RNA, mRNA and tRNA, during [[Transcription|transcription]] and [[Translation|translation]], Thymine is substituted with Uracil meaning Adenine bonds with Uracil instead, forming two hydrogen bonds.&amp;amp;nbsp;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;/table&gt;</summary>
		<author><name>Nnjm2</name></author>
	</entry>
	<entry>
		<id>https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Purines_and_Pyrimidines&amp;diff=16086&amp;oldid=prev</id>
		<title>160349405: Added some text.</title>
		<link rel="alternate" type="text/html" href="https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Purines_and_Pyrimidines&amp;diff=16086&amp;oldid=prev"/>
		<updated>2016-11-17T12:28:45Z</updated>

		<summary type="html">&lt;p&gt;Added some text.&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
				&lt;col class=&quot;diff-marker&quot; /&gt;
				&lt;col class=&quot;diff-content&quot; /&gt;
				&lt;col class=&quot;diff-marker&quot; /&gt;
				&lt;col class=&quot;diff-content&quot; /&gt;
				&lt;tr class=&quot;diff-title&quot; lang=&quot;en&quot;&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 12:28, 17 November 2016&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l1&quot;&gt;Line 1:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Line 1:&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Purines|Purines]] and [[Pyrimidines|pyrimidines]] are the two building blocks of [[Nucleic acids|nucleic acids]]. There are two types of purines: [[Adenine|Adenine]] and [[Guanine|Guanine]], and three different types of pyrimidines: [[Cytosine|cytosine]], [[Thymine|thymine]] and [[Uracil|uracil]] (which is only used in [[MRNA|mRNA]] and [[TRNA|tRNA]]). Purines always bond with pyrimidines via hydrogen bonds. The purine Adenine forms two hydrogen bonds with Thymine and the purine Guanine forms three [[Hydrogen bonds|hydrogen bonds]] with Cytosine. In mRNA and tRNA, during [[Transcription|transcription]] and [[Translation|translation]], Thymine is substituted with Uracil meaning Adenine bonds with Uracil instead.&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Purines|Purines]] and [[Pyrimidines|pyrimidines]] are the two building blocks of [[Nucleic acids|nucleic acids]]. There are two types of purines: [[Adenine|Adenine]] and [[Guanine|Guanine]], and three different types of pyrimidines: [[Cytosine|cytosine]], [[Thymine|thymine]] and [[Uracil|uracil]] (which is only used in &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;RNA,&amp;amp;nbsp;&lt;/ins&gt;[[MRNA|mRNA]] and [[TRNA|tRNA]]). Purines always bond with pyrimidines via hydrogen bonds. The purine Adenine forms two hydrogen bonds with &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;the pyrimidine &lt;/ins&gt;Thymine and the purine Guanine forms three [[Hydrogen bonds|hydrogen bonds]] with &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;the pyramidine &lt;/ins&gt;Cytosine. In &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;RNA, &lt;/ins&gt;mRNA and tRNA, during [[Transcription|transcription]] and [[Translation|translation]], Thymine is substituted with Uracil meaning Adenine bonds with Uracil instead&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;, forming two hydrogen bonds&lt;/ins&gt;.&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;amp;nbsp;&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;/table&gt;</summary>
		<author><name>160349405</name></author>
	</entry>
	<entry>
		<id>https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Purines_and_Pyrimidines&amp;diff=16043&amp;oldid=prev</id>
		<title>Nnjm2: Removed image as it was copyrighted.</title>
		<link rel="alternate" type="text/html" href="https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Purines_and_Pyrimidines&amp;diff=16043&amp;oldid=prev"/>
		<updated>2016-11-14T15:54:06Z</updated>

		<summary type="html">&lt;p&gt;Removed image as it was copyrighted.&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
				&lt;col class=&quot;diff-marker&quot; /&gt;
				&lt;col class=&quot;diff-content&quot; /&gt;
				&lt;col class=&quot;diff-marker&quot; /&gt;
				&lt;col class=&quot;diff-content&quot; /&gt;
				&lt;tr class=&quot;diff-title&quot; lang=&quot;en&quot;&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 15:54, 14 November 2016&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l1&quot;&gt;Line 1:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Line 1:&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Purines|Purines]] and [[Pyrimidines|pyrimidines]] are the two building blocks of [[Nucleic acids|nucleic acids]]. There are two types of purines: [[Adenine|Adenine]] and [[Guanine|Guanine]], and three different types of pyrimidines: [[Cytosine|cytosine]], [[Thymine|thymine]] and [[Uracil|uracil]] (which is only used in [[MRNA|mRNA]] and [[TRNA|tRNA]]). Purines always bond with pyrimidines via hydrogen bonds. The purine Adenine forms two hydrogen bonds with Thymine and the purine Guanine forms three [[Hydrogen bonds|hydrogen bonds]] with Cytosine. In mRNA and tRNA, during [[Transcription|transcription]] and [[Translation|translation]], Thymine is substituted with &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;U[[Image:2-17.jpg|right|300x300px|The structure of the purines and pyrimidines.]]racil &lt;/del&gt;meaning Adenine bonds with Uracil instead.&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Purines|Purines]] and [[Pyrimidines|pyrimidines]] are the two building blocks of [[Nucleic acids|nucleic acids]]. There are two types of purines: [[Adenine|Adenine]] and [[Guanine|Guanine]], and three different types of pyrimidines: [[Cytosine|cytosine]], [[Thymine|thymine]] and [[Uracil|uracil]] (which is only used in [[MRNA|mRNA]] and [[TRNA|tRNA]]). Purines always bond with pyrimidines via hydrogen bonds. The purine Adenine forms two hydrogen bonds with Thymine and the purine Guanine forms three [[Hydrogen bonds|hydrogen bonds]] with Cytosine. In mRNA and tRNA, during [[Transcription|transcription]] and [[Translation|translation]], Thymine is substituted with &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Uracil &lt;/ins&gt;meaning Adenine bonds with Uracil instead.&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;/table&gt;</summary>
		<author><name>Nnjm2</name></author>
	</entry>
	<entry>
		<id>https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Purines_and_Pyrimidines&amp;diff=16042&amp;oldid=prev</id>
		<title>160284704 at 15:39, 14 November 2016</title>
		<link rel="alternate" type="text/html" href="https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Purines_and_Pyrimidines&amp;diff=16042&amp;oldid=prev"/>
		<updated>2016-11-14T15:39:47Z</updated>

		<summary type="html">&lt;p&gt;&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
				&lt;col class=&quot;diff-marker&quot; /&gt;
				&lt;col class=&quot;diff-content&quot; /&gt;
				&lt;col class=&quot;diff-marker&quot; /&gt;
				&lt;col class=&quot;diff-content&quot; /&gt;
				&lt;tr class=&quot;diff-title&quot; lang=&quot;en&quot;&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 15:39, 14 November 2016&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l1&quot;&gt;Line 1:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Line 1:&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Purines|Purines]] and [[Pyrimidines|pyrimidines]] are the two building blocks of [[Nucleic acids|nucleic acids]]. There are two types of purines: [[Adenine|Adenine]] and [[Guanine|Guanine]], and three different types of pyrimidines: [[Cytosine|cytosine]], [[Thymine|thymine]] and [[Uracil|uracil]] (which is only used in [[MRNA|mRNA]] and [[TRNA|tRNA]]). Purines always bond with pyrimidines via hydrogen bonds. The purine Adenine forms two hydrogen bonds with Thymine and the purine Guanine forms three [[Hydrogen bonds|hydrogen bonds]] with Cytosine. In mRNA and tRNA, during [[Transcription|transcription]] and [[Translation|translation]], Thymine is substituted with &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Uracil &lt;/del&gt;meaning Adenine bonds with Uracil instead.&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Purines|Purines]] and [[Pyrimidines|pyrimidines]] are the two building blocks of [[Nucleic acids|nucleic acids]]. There are two types of purines: [[Adenine|Adenine]] and [[Guanine|Guanine]], and three different types of pyrimidines: [[Cytosine|cytosine]], [[Thymine|thymine]] and [[Uracil|uracil]] (which is only used in [[MRNA|mRNA]] and [[TRNA|tRNA]]). Purines always bond with pyrimidines via hydrogen bonds. The purine Adenine forms two hydrogen bonds with Thymine and the purine Guanine forms three [[Hydrogen bonds|hydrogen bonds]] with Cytosine. In mRNA and tRNA, during [[Transcription|transcription]] and [[Translation|translation]], Thymine is substituted with &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;U[[Image:2-17.jpg|right|300x300px|The structure of the purines and pyrimidines.]]racil &lt;/ins&gt;meaning Adenine bonds with Uracil instead.&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;/table&gt;</summary>
		<author><name>160284704</name></author>
	</entry>
	<entry>
		<id>https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Purines_and_Pyrimidines&amp;diff=15290&amp;oldid=prev</id>
		<title>150440657 at 14:24, 17 October 2016</title>
		<link rel="alternate" type="text/html" href="https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Purines_and_Pyrimidines&amp;diff=15290&amp;oldid=prev"/>
		<updated>2016-10-17T14:24:55Z</updated>

		<summary type="html">&lt;p&gt;&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
				&lt;col class=&quot;diff-marker&quot; /&gt;
				&lt;col class=&quot;diff-content&quot; /&gt;
				&lt;col class=&quot;diff-marker&quot; /&gt;
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				&lt;tr class=&quot;diff-title&quot; lang=&quot;en&quot;&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 14:24, 17 October 2016&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l1&quot;&gt;Line 1:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Line 1:&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Purines|Purines]] and [[&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;pyrimidines&lt;/del&gt;|pyrimidines]] are the two building blocks of [[&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;nucleic &lt;/del&gt;acids|nucleic acids]]. There are two types of purines: [[Adenine|Adenine]] and [[Guanine|Guanine]], and three different types of pyrimidines: [[&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;cytosine&lt;/del&gt;|cytosine]], [[&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;thymine&lt;/del&gt;|thymine]] and [[&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;uracil&lt;/del&gt;|uracil]] (which is only used in [[&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;mRNA&lt;/del&gt;|mRNA]] and [[&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;tRNA&lt;/del&gt;|tRNA]]). Purines always bond with pyrimidines via hydrogen bonds. The purine Adenine &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;always &lt;/del&gt;hydrogen bonds with Thymine and the purine Guanine &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;always &lt;/del&gt;[[&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;hydrogen &lt;/del&gt;bonds|hydrogen bonds]] with Cytosine. In mRNA and tRNA, during [[&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;transcription&lt;/del&gt;|transcription]] and [[&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;translation &lt;/del&gt;|translation]]&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;.&amp;amp;nbsp;&lt;/del&gt;Thymine is substituted with Uracil meaning Adenine bonds with Uracil instead.&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Purines|Purines]] and [[&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Pyrimidines&lt;/ins&gt;|pyrimidines]] are the two building blocks of [[&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Nucleic &lt;/ins&gt;acids|nucleic acids]]. There are two types of purines: [[Adenine|Adenine]] and [[Guanine|Guanine]], and three different types of pyrimidines: [[&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Cytosine&lt;/ins&gt;|cytosine]], [[&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Thymine&lt;/ins&gt;|thymine]] and [[&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Uracil&lt;/ins&gt;|uracil]] (which is only used in [[&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;MRNA&lt;/ins&gt;|mRNA]] and [[&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;TRNA&lt;/ins&gt;|tRNA]]). Purines always bond with pyrimidines via hydrogen bonds. The purine Adenine &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;forms two &lt;/ins&gt;hydrogen bonds with Thymine and the purine Guanine &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;forms three &lt;/ins&gt;[[&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Hydrogen &lt;/ins&gt;bonds|hydrogen bonds]] with Cytosine. In mRNA and tRNA, during [[&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Transcription&lt;/ins&gt;|transcription]] and [[&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;Translation&lt;/ins&gt;|translation]]&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;, &lt;/ins&gt;Thymine is substituted with Uracil meaning Adenine bonds with Uracil instead.&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;/table&gt;</summary>
		<author><name>150440657</name></author>
	</entry>
	<entry>
		<id>https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Purines_and_Pyrimidines&amp;diff=7547&amp;oldid=prev</id>
		<title>Nnjm2 at 13:39, 28 November 2012</title>
		<link rel="alternate" type="text/html" href="https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Purines_and_Pyrimidines&amp;diff=7547&amp;oldid=prev"/>
		<updated>2012-11-28T13:39:05Z</updated>

		<summary type="html">&lt;p&gt;&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 13:39, 28 November 2012&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l1&quot;&gt;Line 1:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Line 1:&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;amp;nbsp;&lt;/del&gt;Purines and pyrimidines are the two building blocks of nucleic acids. There are two types of purines : Adenine and Guanine, and three different types of pyrimidines: cytosine, thymine and uracil (which is only used in mRNA and tRNA). Purines always bond with pyrimidines via hydrogen bonds. The purine Adenine always hydrogen bonds with Thymine and the purine Guanine always hydrogen bonds with Cytosine. In mRNA and tRNA, during transcription and translation Thymine is substituted with Uracil meaning Adenine bonds with Uracil instead.&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[Purines|&lt;/ins&gt;Purines&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;]] &lt;/ins&gt;and &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[&lt;/ins&gt;pyrimidines&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;|pyrimidines]] &lt;/ins&gt;are the two building blocks of &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[&lt;/ins&gt;nucleic acids&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;|nucleic acids]]&lt;/ins&gt;. There are two types of purines: &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[&lt;/ins&gt;Adenine&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;|Adenine]] &lt;/ins&gt;and &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[&lt;/ins&gt;Guanine&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;|Guanine]]&lt;/ins&gt;, and three different types of pyrimidines: &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[&lt;/ins&gt;cytosine&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;|cytosine]]&lt;/ins&gt;, &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[thymine|&lt;/ins&gt;thymine&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;]] &lt;/ins&gt;and &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[uracil|&lt;/ins&gt;uracil&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;]] &lt;/ins&gt;(which is only used in &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[&lt;/ins&gt;mRNA&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;|mRNA]] &lt;/ins&gt;and &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[tRNA|&lt;/ins&gt;tRNA&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;]]&lt;/ins&gt;). Purines always bond with pyrimidines via hydrogen bonds. The purine Adenine always hydrogen bonds with Thymine and the purine Guanine always &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[hydrogen bonds|&lt;/ins&gt;hydrogen bonds&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;]] &lt;/ins&gt;with Cytosine. In mRNA and tRNA, during &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[&lt;/ins&gt;transcription&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;|transcription]] &lt;/ins&gt;and &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;[[&lt;/ins&gt;translation &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;|translation]].&amp;amp;nbsp;&lt;/ins&gt;Thymine is substituted with Uracil meaning Adenine bonds with Uracil instead.&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;/table&gt;</summary>
		<author><name>Nnjm2</name></author>
	</entry>
	<entry>
		<id>https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Purines_and_Pyrimidines&amp;diff=7523&amp;oldid=prev</id>
		<title>120056468 at 13:01, 28 November 2012</title>
		<link rel="alternate" type="text/html" href="https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Purines_and_Pyrimidines&amp;diff=7523&amp;oldid=prev"/>
		<updated>2012-11-28T13:01:11Z</updated>

		<summary type="html">&lt;p&gt;&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 13:01, 28 November 2012&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l1&quot;&gt;Line 1:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Line 1:&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&amp;amp;nbsp;Purines and pyrimidines are the two building blocks of nucleic acids. There are two types of purines: Adenine and Guanine, and three different types of pyrimidines: cytosine, thymine and uracil (which is only used in mRNA and tRNA). Purines always bond with pyrimidines via hydrogen bonds. The purine Adenine always hydrogen bonds with Thymine and the purine Guanine always hydrogen bonds with Cytosine. In mRNA and tRNA, during transcription and translation Thymine is substituted with Uracil meaning Adenine bonds with Uracil instead.&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&amp;amp;nbsp;Purines and pyrimidines are the two building blocks of nucleic acids. There are two types of purines : Adenine and Guanine, and three different types of pyrimidines: cytosine, thymine and uracil (which is only used in mRNA and tRNA). Purines always bond with pyrimidines via hydrogen bonds. The purine Adenine always hydrogen bonds with Thymine and the purine Guanine always hydrogen bonds with Cytosine. In mRNA and tRNA, during transcription and translation Thymine is substituted with Uracil meaning Adenine bonds with Uracil instead.&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;/table&gt;</summary>
		<author><name>120056468</name></author>
	</entry>
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