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	<id>https://teaching.ncl.ac.uk/bms/wiki//index.php?action=history&amp;feed=atom&amp;title=Ribonuclease_H</id>
	<title>Ribonuclease H - Revision history</title>
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	<updated>2026-04-13T10:40:21Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
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	<entry>
		<id>https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Ribonuclease_H&amp;diff=22090&amp;oldid=prev</id>
		<title>Nnjm2: Cleaned up the references.</title>
		<link rel="alternate" type="text/html" href="https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Ribonuclease_H&amp;diff=22090&amp;oldid=prev"/>
		<updated>2018-11-22T07:04:53Z</updated>

		<summary type="html">&lt;p&gt;Cleaned up the references.&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 07:04, 22 November 2018&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l1&quot;&gt;Line 1:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Line 1:&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;amp;nbsp;&amp;lt;ref&amp;gt;Hartmann G. Nucleic Acid Immunity. Advances in Immunology. 2017;133:121-169 Available at: https://www.sciencedirect.com/science/article/pii/S0065277616300529&amp;lt;/ref&amp;gt;&lt;/del&gt;Ribonuclease H also known as RNase H is an [[Enzyme|enzyme]] that remove the [[RNA primer|RNA primers]] on the lagging strand during DNA replication. RNA primers are replaced with nucleotides between the Okazaki fragments. &amp;lt;ref&amp;gt;Berg J M, Tymoczko J L, Gatto, Jr G J, Stryer L. Biochemistry Eighth Edition. 2015. W.H. Freeman and Company. New York. Pg 840-842&amp;lt;/ref&amp;gt;During [[DNA replication|DNA replication]], the synthesis of new strand of DNA on the [[Lagging strand|lagging strand]] is discontinuously due to formation of [[Okazaki fragment|Okazaki Fragment]]. RNase H will cleave the RNA primers from the Okazaki fragment and replace it with DNA.&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;amp;nbsp;&lt;/del&gt;[[DNA ligase|DNA ligase]] can from [[Phosphodiester bond|phosphodiester bond]] between the nucleotides added and the Okazaki fragment. This result in the formation of complete continuous strand of new DNA.  &lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;Ribonuclease H also known as RNase H is an [[Enzyme|enzyme]] that remove the [[RNA primer|RNA primers]] on the lagging strand during DNA replication. RNA primers are replaced with nucleotides between the Okazaki fragments&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;lt;ref&amp;gt;Hartmann G. Nucleic Acid Immunity. Advances in Immunology. 2017;133:121-169 Available at: https://www.sciencedirect&lt;/ins&gt;.&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;com/science/article/pii/S0065277616300529&amp;lt;/ref&amp;gt;&lt;/ins&gt;&amp;lt;ref&amp;gt;Berg J M, Tymoczko J L, Gatto, Jr G J, Stryer L. Biochemistry Eighth Edition. 2015. W.H. Freeman and Company. New York. Pg 840-842&amp;lt;/ref&amp;gt;&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;. &lt;/ins&gt;During [[DNA replication|DNA replication]], the synthesis of &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;a &lt;/ins&gt;new strand of DNA on the [[Lagging strand|lagging strand]] is discontinuously due to &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;the &lt;/ins&gt;formation of [[Okazaki fragment|Okazaki Fragment]]. RNase H will cleave the RNA primers from the Okazaki fragment and replace it with DNA. [[DNA ligase|DNA ligase]] can from [[Phosphodiester bond|phosphodiester bond]] between the nucleotides added and the Okazaki fragment. This result in the formation of &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;a &lt;/ins&gt;complete continuous strand of new DNA.  &lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;lt;br&amp;gt; &lt;/del&gt;&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;=== References  ===&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt; &lt;/div&gt;&lt;/td&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-added&quot;&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;lt;references /&amp;gt; &lt;/del&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-added&quot;&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&amp;lt;references /&amp;gt;&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&amp;lt;references /&amp;gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;/table&gt;</summary>
		<author><name>Nnjm2</name></author>
	</entry>
	<entry>
		<id>https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Ribonuclease_H&amp;diff=22088&amp;oldid=prev</id>
		<title>180658378: Created page with &quot;&amp;nbsp;&lt;ref&gt;Hartmann G. Nucleic Acid Immunity. Advances in Immunology. 2017;133:121-169 Available at: https://www.sciencedirect.com/science/article/pii/S0065277616300529&lt;/ref&gt;Ribo...&quot;</title>
		<link rel="alternate" type="text/html" href="https://teaching.ncl.ac.uk/bms/wiki//index.php?title=Ribonuclease_H&amp;diff=22088&amp;oldid=prev"/>
		<updated>2018-11-22T06:10:36Z</updated>

		<summary type="html">&lt;p&gt;Created page with &amp;quot; &amp;lt;ref&amp;gt;Hartmann G. Nucleic Acid Immunity. Advances in Immunology. 2017;133:121-169 Available at: https://www.sciencedirect.com/science/article/pii/S0065277616300529&amp;lt;/ref&amp;gt;Ribo...&amp;quot;&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;&amp;amp;nbsp;&amp;lt;ref&amp;gt;Hartmann G. Nucleic Acid Immunity. Advances in Immunology. 2017;133:121-169 Available at: https://www.sciencedirect.com/science/article/pii/S0065277616300529&amp;lt;/ref&amp;gt;Ribonuclease H also known as RNase H is an [[Enzyme|enzyme]] that remove the [[RNA primer|RNA primers]] on the lagging strand during DNA replication. RNA primers are replaced with nucleotides between the Okazaki fragments. &amp;lt;ref&amp;gt;Berg J M, Tymoczko J L, Gatto, Jr G J, Stryer L. Biochemistry Eighth Edition. 2015. W.H. Freeman and Company. New York. Pg 840-842&amp;lt;/ref&amp;gt;During [[DNA replication|DNA replication]], the synthesis of new strand of DNA on the [[Lagging strand|lagging strand]] is discontinuously due to formation of [[Okazaki fragment|Okazaki Fragment]]. RNase H will cleave the RNA primers from the Okazaki fragment and replace it with DNA.&amp;amp;nbsp;[[DNA ligase|DNA ligase]] can from [[Phosphodiester bond|phosphodiester bond]] between the nucleotides added and the Okazaki fragment. This result in the formation of complete continuous strand of new DNA. &lt;br /&gt;
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&amp;lt;references /&amp;gt; &lt;br /&gt;
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&amp;lt;references /&amp;gt;&lt;/div&gt;</summary>
		<author><name>180658378</name></author>
	</entry>
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