Vancomycin - Revision history

Nnjm2 at 20:25, 6 December 2018

2018-12-06T20:25:20Z

← Older revision		Revision as of 20:25, 6 December 2018
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	=== Mechanism of action as an antibiotic ===		=== Mechanism of action as an antibiotic ===

	Vancomycin works by inhibiting the synthesis of the bacterial [[Cell wall\|cell wall]], specifically by averting the reaction implying the linkage between the [[Peptidoglycan\|peptidoglycan]] precursors. In comparison to other antibiotics such as [[Penicillin\|penicillin]], this drug binds to the [[Substrate\|substrate]] (D-alanyl-D-alanine terminal dipeptide of peptidoglycan precursors) , not the [[Enzyme\|enzyme]] in order to inhibit the synthesis of the cell wall. This antibiotic has a great effect on [[Gram positive bacteria\|Gram-positive]] [[Gram positive bacteria\|bacteria]], which use the thick peptidoglycan cell wall for protection, but recently bacteria have been developing [[Antibiotic resistance\|resistance]] to it, so scientists are obliged to look for alternatives<ref>University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018]; Available from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref>.		Vancomycin works by inhibiting the synthesis of the bacterial [[Cell wall\|cell wall]], specifically by averting the reaction implying the linkage between the [[Peptidoglycan\|peptidoglycan]] precursors. In comparison to other antibiotics such as [[Penicillin\|penicillin]], this drug binds to the [[Substrate\|substrate]] (D-alanyl-D-alanine terminal dipeptide of peptidoglycan precursors), not the [[Enzyme\|enzyme]] in order to inhibit the synthesis of the cell wall. This antibiotic has a great effect on [[Gram positive bacteria\|Gram-positive]] [[Gram positive bacteria\|bacteria]], which use the thick peptidoglycan cell wall for protection, but recently bacteria have been developing [[Antibiotic resistance\|resistance]] to it, so scientists are obliged to look for alternatives<ref>University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018]; Available from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref>.

	=== Alternatives ===		=== Alternatives ===

Nnjm2 at 20:25, 6 December 2018

2018-12-06T20:25:07Z

← Older revision		Revision as of 20:25, 6 December 2018
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	Vancomycin is a complex [[Glycopeptide\|glycopeptide]]<ref ~~name="(1)"~~>University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018]; Available from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref> produced by the soil [[Bacteria\|bacterium ]][[Amycolatopsis orientalis\|Amycolatopsis orientalis]]<ref ~~name="(2)"~~>European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018]; Available from: https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref>. It is also known as 'Mississippi Mud' due to its dark colour and its general appearance when extracted as a natural product<ref>Hamilton.Students Researching Vancomycin Structure. 2009 [cited 06/12/2018]; Available from: https://www.hamilton.edu/news/story/students-researching-vancomycin-structure</ref>. Its main usage is as an [[Antibiotic\|antibiotic]], often given intravenously, used to treat skin infections, endocarditis, bloodstream infections, bone and joint infections and [[Meningitis\|meningitis]] caused by the methicillin-resistant [[Staphylococcus aureus\|Staphylococcus aureus]]<ref>European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018]; Available from: https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref>.		Vancomycin is a complex [[Glycopeptide\|glycopeptide]]<ref>University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018]; Available from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref> produced by the soil [[Bacteria\|bacterium ]][[Amycolatopsis orientalis\|Amycolatopsis orientalis]]<ref>European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018]; Available from: https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref>. It is also known as 'Mississippi Mud' due to its dark colour and its general appearance when extracted as a natural product<ref>Hamilton.Students Researching Vancomycin Structure. 2009 [cited 06/12/2018]; Available from: https://www.hamilton.edu/news/story/students-researching-vancomycin-structure</ref>. Its main usage is as an [[Antibiotic\|antibiotic]], often given intravenously, used to treat skin infections, endocarditis, bloodstream infections, bone and joint infections and [[Meningitis\|meningitis]] caused by the methicillin-resistant [[Staphylococcus aureus\|Staphylococcus aureus]]<ref>European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018]; Available from: https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref>.

	=== Mechanism of action as an antibiotic ===		=== Mechanism of action as an antibiotic ===

	Vancomycin works by inhibiting the synthesis of the bacterial [[Cell wall\|cell wall]], specifically by averting the reaction implying the linkage between the [[Peptidoglycan\|peptidoglycan]] precursors. In comparison to other antibiotics such as [[Penicillin\|penicillin]], this drug binds to the [[Substrate\|substrate]] (D-alanyl-D-alanine terminal dipeptide of peptidoglycan precursors) , not the [[Enzyme\|enzyme]] in order to inhibit the synthesis of the cell wall. This antibiotic has a great effect on [[Gram positive bacteria\|Gram-positive]][[Gram positive bacteria\|bacteria]], which use the thick peptidoglycan cell wall for protection, but recently bacteria have been developing [[Antibiotic resistance\|resistance]] to it, so scientists are obliged to look for alternatives<ref>University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018]; Available from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref>.		Vancomycin works by inhibiting the synthesis of the bacterial [[Cell wall\|cell wall]], specifically by averting the reaction implying the linkage between the [[Peptidoglycan\|peptidoglycan]] precursors. In comparison to other antibiotics such as [[Penicillin\|penicillin]], this drug binds to the [[Substrate\|substrate]] (D-alanyl-D-alanine terminal dipeptide of peptidoglycan precursors) , not the [[Enzyme\|enzyme]] in order to inhibit the synthesis of the cell wall. This antibiotic has a great effect on [[Gram positive bacteria\|Gram-positive]] [[Gram positive bacteria\|bacteria]], which use the thick peptidoglycan cell wall for protection, but recently bacteria have been developing [[Antibiotic resistance\|resistance]] to it, so scientists are obliged to look for alternatives<ref>University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018]; Available from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref>.

	=== Alternatives ===		=== Alternatives ===

Nnjm2 at 20:24, 6 December 2018

2018-12-06T20:24:19Z

← Older revision		Revision as of 20:24, 6 December 2018
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	~~'''~~Vancomycin~~'''~~ is a complex [[Glycopeptide\|glycopeptide]]~~ <sup>~~<ref name="(1)">University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018];~~fckLRAvailable~~ from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref>~~</sup> ~~produced by the soil [[Bacteria\|bacterium~~ ~~]][[Amycolatopsis orientalis\|Amycolatopsis orientalis]]~~ ~~<ref name="(2)">European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018];~~fckLRAvailable~~ from:~~fckLRhttps~~://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref~~><sup> </sup~~>. It is also known as 'Mississippi Mud' due to its dark colour and its general appearance when extracted as a natural product~~<sup>~~<ref ~~name="(3)"~~>Hamilton.Students Researching Vancomycin Structure. 2009 [cited 06/12/2018];~~fckLRAvailable~~ from: https://www.hamilton.edu/news/story/students-researching-vancomycin-structure</ref~~></sup~~>. Its main usage is as an [[Antibiotic\|antibiotic]], often given intravenously, used to treat skin infections, endocarditis, bloodstream infections, bone and joint infections and [[Meningitis\|meningitis]] caused by the~~ ~~methicillin-resistant [[Staphylococcus aureus\|Staphylococcus~~ ~~aureus]]~~  <sup>~~<ref ~~name="(2)"~~>European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018];~~fckLRAvailable~~ from: https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref~~></sup~~>.~~   ~~		Vancomycin is a complex [[Glycopeptide\|glycopeptide]]<ref name="(1)">University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018]; Available from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref> produced by the soil [[Bacteria\|bacterium ]][[Amycolatopsis orientalis\|Amycolatopsis orientalis]]<ref name="(2)">European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018]; Available from: https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref>. It is also known as 'Mississippi Mud' due to its dark colour and its general appearance when extracted as a natural product<ref>Hamilton.Students Researching Vancomycin Structure. 2009 [cited 06/12/2018]; Available from: https://www.hamilton.edu/news/story/students-researching-vancomycin-structure</ref>. Its main usage is as an [[Antibiotic\|antibiotic]], often given intravenously, used to treat skin infections, endocarditis, bloodstream infections, bone and joint infections and [[Meningitis\|meningitis]] caused by the methicillin-resistant [[Staphylococcus aureus\|Staphylococcus aureus]]<ref>European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018]; Available from: https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref>.

	= ''Mechanism of action as an antibiotic~~<u></u>''~~ =		=== Mechanism of action as an antibiotic ===

	Vancomycin works by inhibiting the synthesis of the bacterial [[Cell wall\|cell wall]], specifically by averting the reaction implying the linkage between the [[Peptidoglycan\|peptidoglycan]] precursors. In comparison to other antibiotics such as [[Penicillin\|penicillin]], this drug binds to the [[Substrate\|substrate]] (~~<span style="font-size: 13.28px;">~~D-alanyl-D-alanine terminal dipeptide of peptidoglycan precursors)~~</span><span style="font-size: 13.28px;"> ~~,~~</span><span style="font-size: 13.28px;"> </span><span style="font-size: 13.28px;">~~not the [[Enzyme\|enzyme]]~~ </span><span style="font-size: 13.28px;">~~in order to inhibit the synthesis of the cell wall~~</span><span style="font-size: 13.28px;">~~.~~ </span><span style="font-size: 13.28px;"> ~~This antibiotic has a great effect on~~ </span><span style="font-size: 13.28px;">~~[[Gram positive bacteria\|Gram-positive]]~~</span><span style="font-size: 13.28px;">~~[[Gram positive bacteria\|~~ ~~bacteria]], which use the thick peptidoglycan cell wall for protection, but recently bacteria have been developing [[Antibiotic resistance\|resistance]] to it, so scientists are obliged to look for~~ </span><span style="font-size: 13.28px;">~~alternatives~~</span>~~<ref ~~name="(1)"~~>University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018];~~fckLRAvailable~~ from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref~~><span style="font-size: 13.28px;"><sup> </sup></span><span style="font-size: 13.28px;"~~>.~~</span>~~		Vancomycin works by inhibiting the synthesis of the bacterial [[Cell wall\|cell wall]], specifically by averting the reaction implying the linkage between the [[Peptidoglycan\|peptidoglycan]] precursors. In comparison to other antibiotics such as [[Penicillin\|penicillin]], this drug binds to the [[Substrate\|substrate]] (D-alanyl-D-alanine terminal dipeptide of peptidoglycan precursors) , not the [[Enzyme\|enzyme]] in order to inhibit the synthesis of the cell wall. This antibiotic has a great effect on [[Gram positive bacteria\|Gram-positive]][[Gram positive bacteria\|bacteria]], which use the thick peptidoglycan cell wall for protection, but recently bacteria have been developing [[Antibiotic resistance\|resistance]] to it, so scientists are obliged to look for alternatives<ref>University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018]; Available from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref>.

	= ''Alternatives'' =		=== Alternatives ===

	~~<u></u>~~A new version of Vancomycin is being worked on that implies the introduction of a not often seen [[Carbohydrate\|carbohydrate]] group, respectively seven-membered rings, which will hopefully be different enough for bacteria not to recognise<ref name="(3)">Hamilton. Students Researching Vancomycin Structure. 2009 [cited 06/12/2018];~~fckLRAvailable~~ from: https://www.hamilton.edu/news/story/students-researching-vancomycin-structure</ref>.~~<u></u><u></u>~~		A new version of Vancomycin is being worked on that implies the introduction of a not often seen [[Carbohydrate\|carbohydrate]] group, respectively seven-membered rings, which will hopefully be different enough for bacteria not to recognise<ref name="(3)">Hamilton. Students Researching Vancomycin Structure. 2009 [cited 06/12/2018]; Available from: https://www.hamilton.edu/news/story/students-researching-vancomycin-structure</ref>.

	= ''References'' =		=== References ===

	''<references /~~>''~~		<references />

	~~<br~~>

180030389 at 12:31, 6 December 2018

2018-12-06T12:31:15Z

← Older revision		Revision as of 12:31, 6 December 2018
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	'''Vancomycin''' is a complex [[Glycopeptide\|glycopeptide]] <sup><ref name="(1)">University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018];~~Available~~ from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref></sup> produced by the soil [[Bacteria\|bacterium ]][[Amycolatopsis orientalis\|Amycolatopsis orientalis]] <ref name="(2)">European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018];fckLRAvailable from:fckLRhttps://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref><sup> </sup>. It is also known as 'Mississippi Mud' due to its dark colour and its general appearance when extracted as a natural product<sup><ref name="(3)">Hamilton.Students Researching Vancomycin Structure. 2009 [cited 06/12/2018];fckLRAvailable from: https://www.hamilton.edu/news/story/students-researching-vancomycin-structure</ref></sup>. Its main usage is as an [[Antibiotic\|antibiotic]], often given intravenously, used to treat skin infections, endocarditis, bloodstream infections, bone and joint infections and [[Meningitis\|meningitis]] caused by the methicillin-resistant [[Staphylococcus aureus\|Staphylococcus aureus]]  <sup><ref name="(2)">European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018];fckLRAvailable from: https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref></sup>.		'''Vancomycin''' is a complex [[Glycopeptide\|glycopeptide]] <sup><ref name="(1)">University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018];fckLRAvailable from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref></sup> produced by the soil [[Bacteria\|bacterium ]][[Amycolatopsis orientalis\|Amycolatopsis orientalis]] <ref name="(2)">European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018];fckLRAvailable from:fckLRhttps://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref><sup> </sup>. It is also known as 'Mississippi Mud' due to its dark colour and its general appearance when extracted as a natural product<sup><ref name="(3)">Hamilton.Students Researching Vancomycin Structure. 2009 [cited 06/12/2018];fckLRAvailable from: https://www.hamilton.edu/news/story/students-researching-vancomycin-structure</ref></sup>. Its main usage is as an [[Antibiotic\|antibiotic]], often given intravenously, used to treat skin infections, endocarditis, bloodstream infections, bone and joint infections and [[Meningitis\|meningitis]] caused by the methicillin-resistant [[Staphylococcus aureus\|Staphylococcus aureus]]  <sup><ref name="(2)">European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018];fckLRAvailable from: https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref></sup>.

	= ''Mechanism of action as an antibiotic<u></u>'' =		= ''Mechanism of action as an antibiotic<u></u>'' =

180030389 at 12:29, 6 December 2018

2018-12-06T12:29:09Z

← Older revision		Revision as of 12:29, 6 December 2018
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	'''Vancomycin''' is a complex [[Glycopeptide\|glycopeptide]] <sup><ref name="(1)">University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018];Available from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref></sup> produced by the soil [[Bacteria\|bacterium ]][[Amycolatopsis orientalis\|Amycolatopsis orientalis<ref name="(2)">European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018];fckLRAvailable from:fckLRhttps://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref>]]<sup> </sup>. It is also known as 'Mississippi Mud' due to its dark colour and its general appearance when extracted as a natural product<sup><ref name="(3)">Hamilton.Students Researching Vancomycin Structure. 2009 [cited 06/12/2018];fckLRAvailable from: https://www.hamilton.edu/news/story/students-researching-vancomycin-structure</ref></sup>. Its main usage is as an [[Antibiotic\|antibiotic]], often given intravenously, used to treat skin infections, endocarditis, bloodstream infections, bone and joint infections and [[Meningitis\|meningitis]] caused by the methicillin-resistant [[Staphylococcus ~~aureas~~\|Staphylococcus aureus<sup><ref name="(2)">European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018];fckLRAvailable from: https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref></sup>]].		'''Vancomycin''' is a complex [[Glycopeptide\|glycopeptide]] <sup><ref name="(1)">University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018];Available from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref></sup> produced by the soil [[Bacteria\|bacterium ]][[Amycolatopsis orientalis\|Amycolatopsis orientalis]] <ref name="(2)">European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018];fckLRAvailable from:fckLRhttps://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref><sup> </sup>. It is also known as 'Mississippi Mud' due to its dark colour and its general appearance when extracted as a natural product<sup><ref name="(3)">Hamilton.Students Researching Vancomycin Structure. 2009 [cited 06/12/2018];fckLRAvailable from: https://www.hamilton.edu/news/story/students-researching-vancomycin-structure</ref></sup>. Its main usage is as an [[Antibiotic\|antibiotic]], often given intravenously, used to treat skin infections, endocarditis, bloodstream infections, bone and joint infections and [[Meningitis\|meningitis]] caused by the methicillin-resistant [[Staphylococcus aureus\|Staphylococcus aureus]]  <sup><ref name="(2)">European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018];fckLRAvailable from: https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref></sup>.

	= ''Mechanism of action as an antibiotic<u></u>'' =		= ''Mechanism of action as an antibiotic<u></u>'' =

	Vancomycin works by inhibiting the synthesis of the bacterial [[Cell wall\|cell wall]], specifically by averting the reaction implying the linkage between the [[Peptidoglycan\|peptidoglycan]] precursors. In comparison to other antibiotics such as [[Penicillin\|penicillin]], this drug binds to the [[Substrate\|substrate]] (<span style="font-size: 13.28px;">D-alanyl-D-alanine terminal dipeptide of peptidoglycan precursors)</span><span style="font-size: 13.28px;"> ,</span><span style="font-size: 13.28px;"> </span><span style="font-size: 13.28px;">not the [[Enzyme\|enzyme]] </span><span style="font-size: 13.28px;">in order to inhibit the synthesis of the cell wall</span><span style="font-size: 13.28px;">. </span><span style="font-size: 13.28px;"> This antibiotic has a great effect on </span><span style="font-size: 13.28px;">[[Gram positive bacteria\|Gram-positive]]</span><span style="font-size: 13.28px;">[[Gram positive bacteria\| bacteria]], which use the thick peptidoglycan cell wall for protection, but recently bacteria have been developing [[Antibiotic resistance\|resistance]] to it, so scientists are obliged to look for ~~alternatives<sup>~~ </~~sup~~></span><ref name="(1)">University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018];fckLRAvailable from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref><span style="font-size: 13.28px;">.</span>		Vancomycin works by inhibiting the synthesis of the bacterial [[Cell wall\|cell wall]], specifically by averting the reaction implying the linkage between the [[Peptidoglycan\|peptidoglycan]] precursors. In comparison to other antibiotics such as [[Penicillin\|penicillin]], this drug binds to the [[Substrate\|substrate]] (<span style="font-size: 13.28px;">D-alanyl-D-alanine terminal dipeptide of peptidoglycan precursors)</span><span style="font-size: 13.28px;"> ,</span><span style="font-size: 13.28px;"> </span><span style="font-size: 13.28px;">not the [[Enzyme\|enzyme]] </span><span style="font-size: 13.28px;">in order to inhibit the synthesis of the cell wall</span><span style="font-size: 13.28px;">. </span><span style="font-size: 13.28px;"> This antibiotic has a great effect on </span><span style="font-size: 13.28px;">[[Gram positive bacteria\|Gram-positive]]</span><span style="font-size: 13.28px;">[[Gram positive bacteria\| bacteria]], which use the thick peptidoglycan cell wall for protection, but recently bacteria have been developing [[Antibiotic resistance\|resistance]] to it, so scientists are obliged to look for </span><span style="font-size: 13.28px;">alternatives</span><ref name="(1)">University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018];fckLRAvailable from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref><span style="font-size: 13.28px;"><sup> </sup></span><span style="font-size: 13.28px;">.</span>

	= ''Alternatives'' =		= ''Alternatives'' =

180030389: Created page with "'''Vancomycin''' is a complex glycopeptide ^{University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018];Available from: h..."}

2018-12-06T12:23:26Z

Created page with "'''Vancomycin''' is a complex glycopeptide <ref name="(1)">University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018];Available from: h..."

New page

'''Vancomycin''' is a complex [[Glycopeptide|glycopeptide]] <ref name="(1)">University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018];Available from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref> produced by the soil [[Bacteria|bacterium ]][[Amycolatopsis orientalis|Amycolatopsis orientalis<ref name="(2)">European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018];fckLRAvailable from:fckLRhttps://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref>]] . It is also known as 'Mississippi Mud' due to its dark colour and its general appearance when extracted as a natural product<ref name="(3)">Hamilton.Students Researching Vancomycin Structure. 2009 [cited 06/12/2018];fckLRAvailable from: https://www.hamilton.edu/news/story/students-researching-vancomycin-structure</ref>. Its main usage is as an [[Antibiotic|antibiotic]], often given intravenously, used to treat skin infections, endocarditis, bloodstream infections, bone and joint infections and [[Meningitis|meningitis]] caused by the methicillin-resistant [[Staphylococcus aureas|Staphylococcus aureus<ref name="(2)">European Bioinformatics Institute. CHEBI:28001 - vancomycin. 2017 [cited 06/12/2018];fckLRAvailable from: https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28001</ref>]]. 

= ''Mechanism of action as an antibiotic'' =

Vancomycin works by inhibiting the synthesis of the bacterial [[Cell wall|cell wall]], specifically by averting the reaction implying the linkage between the [[Peptidoglycan|peptidoglycan]] precursors. In comparison to other antibiotics such as [[Penicillin|penicillin]], this drug binds to the [[Substrate|substrate]] (D-alanyl-D-alanine terminal dipeptide of peptidoglycan precursors) , not the [[Enzyme|enzyme]] in order to inhibit the synthesis of the cell wall.  This antibiotic has a great effect on [[Gram positive bacteria|Gram-positive]][[Gram positive bacteria| bacteria]], which use the thick peptidoglycan cell wall for protection, but recently bacteria have been developing [[Antibiotic resistance|resistance]] to it, so scientists are obliged to look for alternatives <ref name="(1)">University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018];fckLRAvailable from: http://www.chm.bris.ac.uk/motm/vancomycin/text.htm</ref>.

= ''Alternatives'' =

A new version of Vancomycin is being worked on that implies the introduction of a not often seen [[Carbohydrate|carbohydrate]] group, respectively seven-membered rings, which will hopefully be different enough for bacteria not to recognise<ref name="(3)">Hamilton. Students Researching Vancomycin Structure. 2009 [cited 06/12/2018];fckLRAvailable from: https://www.hamilton.edu/news/story/students-researching-vancomycin-structure</ref>.

= ''References'' =

''<references />''

Vancomycin - Revision history

Nnjm2 at 20:25, 6 December 2018

Nnjm2 at 20:25, 6 December 2018

Nnjm2 at 20:24, 6 December 2018

180030389 at 12:31, 6 December 2018

180030389 at 12:29, 6 December 2018

180030389: Created page with "'''Vancomycin''' is a complex glycopeptide University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018];Available from: h..."

180030389: Created page with "'''Vancomycin''' is a complex glycopeptide ^{University of Kent. Vancomycin-a vital antibiotic. 1997 [cited 06/12/2018];Available from: h..."}