XXXX syndrome - Revision history

180158524: Added a link to Barr bodies page

2018-11-16T13:40:22Z

Added a link to Barr bodies page

← Older revision		Revision as of 13:40, 16 November 2018
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	Also known as [[Tetrasomy\|tetrasomy]] X or 48, XXX.		Also known as [[Tetrasomy\|tetrasomy]] X or 48, XXX.

	XXXX syndrome is an uncommon, sex-linked chromosomal condition found only in females<ref>N Ayari, A Berge, S Howell, N Tartaglia. Orphanet. Tetrasomy X. 2016. [Available from: http://www.orpha.net/consor/cgi-bin/Disease_Search.php?lng=EN&amp;amp;amp;amp;amp;amp;amp;data_id=390]</ref>.		XXXX syndrome is an uncommon, sex-linked chromosomal condition found only in females<ref>N Ayari, A Berge, S Howell, N Tartaglia. Orphanet. Tetrasomy X. 2016. [Available from: http://www.orpha.net/consor/cgi-bin/Disease_Search.php?lng=EN&amp;amp;amp;amp;amp;amp;amp;amp;data_id=390]</ref>.

	=== Cause ===		=== Cause ===

	Due to repeated [[Nondisjunction\|nondisjunction]] during [[Meiosis\|meiosis]], a mother can produce an [[Ovum\|ovum]] containing three or four [[Javascript:void(0);/1480868618216/\|X chromosomes]], rather than the normal number of one. If an ovum containing three X chromosomes is fertilised by a sperm cell also containing an X chromosome, then the offspring will have a total number of four X chromosomes and is said to have XXXX syndrome. The syndrome can also be caused by an X-carrying sperm fertilising an egg containing four X chromosomes, however the fifth X chromosome is lost early in development, resulting in the offspring again inheriting four X chromosomes<ref>National Center for Advancing Translational Sciences. Tetrasomy X. 2014. [Available from: https://rarediseases.info.nih.gov/diseases/7754/tetrasomy-x]</ref>. The nucleus of a female with XXXX syndrome contains 3 Barr bodies.<br>		Due to repeated [[Nondisjunction\|nondisjunction]] during [[Meiosis\|meiosis]], a mother can produce an [[Ovum\|ovum]] containing three or four [[Javascript:void(0);/1480868618216/\|X chromosomes]], rather than the normal number of one. If an ovum containing three X chromosomes is fertilised by a sperm cell also containing an X chromosome, then the offspring will have a total number of four X chromosomes and is said to have XXXX syndrome. The syndrome can also be caused by an X-carrying sperm fertilising an egg containing four X chromosomes, however the fifth X chromosome is lost early in development, resulting in the offspring again inheriting four X chromosomes<ref>National Center for Advancing Translational Sciences. Tetrasomy X. 2014. [Available from: https://rarediseases.info.nih.gov/diseases/7754/tetrasomy-x]</ref>. The nucleus of a female with XXXX syndrome contains 3 [[Barr_bodies\|Barr bodies]].<br>

	=== Symptoms ===		=== Symptoms ===

180144228 at 12:24, 16 November 2018

2018-11-16T12:24:57Z

← Older revision		Revision as of 12:24, 16 November 2018
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	=== Cause ===		=== Cause ===

	Due to repeated [[Nondisjunction\|nondisjunction]] during [[Meiosis\|meiosis]], a mother can produce an [[Ovum\|ovum]] containing three or four [[Javascript:void(0);/1480868618216/\|X chromosomes]], rather than the normal number of one. If an ovum containing three X chromosomes is fertilised by a sperm cell also containing an X chromosome, then the offspring will have a total number of four X chromosomes and is said to have XXXX syndrome. The syndrome can also be caused by an X-carrying sperm fertilising an egg containing four X chromosomes, however the fifth X chromosome is lost early in development, resulting in the offspring again inheriting four X chromosomes<ref>National Center for Advancing Translational Sciences. Tetrasomy X. 2014. [Available from: https://rarediseases.info.nih.gov/diseases/7754/tetrasomy-x]</ref>.<br>		Due to repeated [[Nondisjunction\|nondisjunction]] during [[Meiosis\|meiosis]], a mother can produce an [[Ovum\|ovum]] containing three or four [[Javascript:void(0);/1480868618216/\|X chromosomes]], rather than the normal number of one. If an ovum containing three X chromosomes is fertilised by a sperm cell also containing an X chromosome, then the offspring will have a total number of four X chromosomes and is said to have XXXX syndrome. The syndrome can also be caused by an X-carrying sperm fertilising an egg containing four X chromosomes, however the fifth X chromosome is lost early in development, resulting in the offspring again inheriting four X chromosomes<ref>National Center for Advancing Translational Sciences. Tetrasomy X. 2014. [Available from: https://rarediseases.info.nih.gov/diseases/7754/tetrasomy-x]</ref>. The nucleus of a female with XXXX syndrome contains 3 Barr bodies.<br>

	=== Symptoms ===		=== Symptoms ===

Nnjm2: Cleaned up layout. Added links.

2016-12-04T17:23:49Z

Cleaned up layout. Added links.

← Older revision		Revision as of 17:23, 4 December 2016
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	~~ ~~Also known as [[Tetrasomy\|tetrasomy]] X or 48, XXX.		Also known as [[Tetrasomy\|tetrasomy]] X or 48, XXX.

	XXXX syndrome is an uncommon, sex-linked chromosomal condition found only in females<ref>N Ayari, A Berge, S Howell, N Tartaglia. Orphanet. Tetrasomy X. 2016. [Available from: http://www.orpha.net/consor/cgi-bin/Disease_Search.php?lng=EN&amp;amp;amp;amp;amp;amp;data_id=390]</ref>.		XXXX syndrome is an uncommon, sex-linked chromosomal condition found only in females<ref>N Ayari, A Berge, S Howell, N Tartaglia. Orphanet. Tetrasomy X. 2016. [Available from: http://www.orpha.net/consor/cgi-bin/Disease_Search.php?lng=EN&amp;amp;amp;amp;amp;amp;amp;data_id=390]</ref>.

	== Cause ==		=== Cause ===

	Due to repeated [[Nondisjunction\|nondisjunction]] during [[Meiosis\|meiosis]], a mother can produce an [[Ovum\|ovum]] containing three or four [[Javascript:void(0);/1480868618216/\|X chromosomes]], rather than the normal number of one. If an ovum containing three X chromosomes is fertilised by a sperm cell also containing an X chromosome, then the offspring will have a total number of four X chromosomes and is said to have XXXX syndrome. The syndrome can also be caused by an X-carrying sperm fertilising an egg containing four X chromosomes, however the fifth X chromosome is lost early in development, resulting in the offspring again inheriting four X chromosomes<ref>National Center for Advancing Translational Sciences. Tetrasomy X. 2014. [Available from: https://rarediseases.info.nih.gov/diseases/7754/tetrasomy-x]</ref>.<br>		Due to repeated [[Nondisjunction\|nondisjunction]] during [[Meiosis\|meiosis]], a mother can produce an [[Ovum\|ovum]] containing three or four [[Javascript:void(0);/1480868618216/\|X chromosomes]], rather than the normal number of one. If an ovum containing three X chromosomes is fertilised by a sperm cell also containing an X chromosome, then the offspring will have a total number of four X chromosomes and is said to have XXXX syndrome. The syndrome can also be caused by an X-carrying sperm fertilising an egg containing four X chromosomes, however the fifth X chromosome is lost early in development, resulting in the offspring again inheriting four X chromosomes<ref>National Center for Advancing Translational Sciences. Tetrasomy X. 2014. [Available from: https://rarediseases.info.nih.gov/diseases/7754/tetrasomy-x]</ref>.<br>

	== Symptoms ==		=== Symptoms ===

	Females with XXXX syndrome frequently have problems with infection, their heart, kidneys, palate, movement and joints<ref>R Rooman, M Hultén. Unique The Rare Chromosome Disorder Support Group. Tetrasomy X. 2005. [Available from: http://www.rarechromo.org/html/DisorderGuides.asp]</ref>.		Females with XXXX syndrome frequently have problems with infection, their heart, kidneys, palate, movement and joints<ref>R Rooman, M Hultén. Unique The Rare Chromosome Disorder Support Group. Tetrasomy X. 2005. [Available from: http://www.rarechromo.org/html/DisorderGuides.asp]</ref>.

160348877: Added texts, links and referencing.

2016-12-04T16:30:05Z

Added texts, links and referencing.

New page

 Also known as [[Tetrasomy|tetrasomy]] X or 48, XXX.

XXXX syndrome is an uncommon, sex-linked chromosomal condition found only in females<ref>N Ayari, A Berge, S Howell, N Tartaglia. Orphanet. Tetrasomy X. 2016. [Available from: http://www.orpha.net/consor/cgi-bin/Disease_Search.php?lng=EN&amp;amp;amp;amp;amp;amp;data_id=390]</ref>.

== Cause ==

Due to repeated [[Nondisjunction|nondisjunction]] during [[Meiosis|meiosis]], a mother can produce an [[Ovum|ovum]] containing three or four [[Javascript:void(0);/*1480868618216*/|X chromosomes]], rather than the normal number of one. If an ovum containing three X chromosomes is fertilised by a sperm cell also containing an X chromosome, then the offspring will have a total number of four X chromosomes and is said to have XXXX syndrome. The syndrome can also be caused by an X-carrying sperm fertilising an egg containing four X chromosomes, however the fifth X chromosome is lost early in development, resulting in the offspring again inheriting four X chromosomes<ref>National Center for Advancing Translational Sciences. Tetrasomy X. 2014. [Available from: https://rarediseases.info.nih.gov/diseases/7754/tetrasomy-x]</ref>.<br>

== Symptoms ==

Females with XXXX syndrome frequently have problems with infection, their heart, kidneys, palate, movement and joints<ref>R Rooman, M Hultén. Unique The Rare Chromosome Disorder Support Group. Tetrasomy X. 2005. [Available from: http://www.rarechromo.org/html/DisorderGuides.asp]</ref>.

=== References: ===

<references />