Fibroblasts: Difference between revisions

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Fibroblasts: cells of the connective tissue responsible for secreting connective proteins.
 
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== Fibroblasts ==
Fibroblasts are cells that are usually found in [[Connective tissue]] as part of the [[Extracellular matrix]], ECM. These cells synthesise [[Collagen]] amongst other ECM constituents&nbsp;<ref>Lodish H. et al.2008. Molecular Cell Biology. 6th edition. New York.W. H. Freeman and Company Publishing. p396</ref>


Fibroblasts are cells that are usually found in [[connective tissue]] as part of the [[extracellular matrix]], ECM. These cells synthesise [[collagen]] amongst other ECM constituents.¹
The presence of collagen on in the ECM allows interactions between cell-adhesion molecules, CAMs, therefore providing a solid mooring to surfaces thus making them ideal cells to be grown ''[[In vitro]]&nbsp;''<ref>Cassimeris L. et al (ed) .2011. Lewin's Cells. 2nd edition. USA.Jones and Bartlett Publishers. p742</ref>; without such properties normal cells cannot grow and divide, they are said to be anchorage dependent. [[Cancer]] cells on the other hand are anchorage independent which means that they can grow without the need to be attached to a surface<ref>Cassimeris L. et al (ed) .2011. Lewin's Cells. 2nd edition. USA.Jones and Bartlett Publishers. p742</ref>.<br>


The presence of collagen on in the ECM allows interactions between cell-adhesion molecules, CAMs, therefore providing a solid mooring to surfaces thus making them ideal cells to be grown ''in vivo'' ²; without such properties normal cells cannot grow and divide, they are said to be anchorage dependent.Cancer cells on the other hand are anchorage independent which means that they can grow without the need to be attached to a surface.²
=== References ===


 
<references />
 
 
[1] Lodish H. et al.2008. Molecular Cell Biology. 6th edition. New York.W. H. Freeman and Company Publishing. p396
[2] Cassimeris L. et al (ed) .2011. Lewin's Cells. 2nd edition. USA.Jones and Bartlett Publishers. p742

Latest revision as of 22:54, 27 November 2014

Fibroblasts are cells that are usually found in Connective tissue as part of the Extracellular matrix, ECM. These cells synthesise Collagen amongst other ECM constituents [1]

The presence of collagen on in the ECM allows interactions between cell-adhesion molecules, CAMs, therefore providing a solid mooring to surfaces thus making them ideal cells to be grown In vitro [2]; without such properties normal cells cannot grow and divide, they are said to be anchorage dependent. Cancer cells on the other hand are anchorage independent which means that they can grow without the need to be attached to a surface[3].

References

  1. ↑ Lodish H. et al.2008. Molecular Cell Biology. 6th edition. New York.W. H. Freeman and Company Publishing. p396
  2. ↑ Cassimeris L. et al (ed) .2011. Lewin's Cells. 2nd edition. USA.Jones and Bartlett Publishers. p742
  3. ↑ Cassimeris L. et al (ed) .2011. Lewin's Cells. 2nd edition. USA.Jones and Bartlett Publishers. p742
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