Neurodegeneration: Difference between revisions
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'''Neurodegeneration''' describes the loss of structure or function to nervous tissue<ref>Merriam-Webster. (n.d.). Medical Dictionary. Available: http://www.merriam-webster.com/medlineplus/neurodegeneration. Last accessed 09/11/2014.</ref>. Neurodegenerative diseases include [[Alzheimer's disease|Alzheimer’s]], [[ALS|ALS]], [[Huntington’s disease|Huntington’s]] and [[Parkinson’s|Parkinson’s]]<ref>Bredeson, D. (2006). Cell death in the nervous system. Nature, 796-802.</ref>. | '''Neurodegeneration''' describes the loss of structure or function to nervous tissue<ref>Merriam-Webster. (n.d.). Medical Dictionary. Available: http://www.merriam-webster.com/medlineplus/neurodegeneration. Last accessed 09/11/2014.</ref>. Neurodegenerative diseases include [[Alzheimer's disease|Alzheimer’s]], [[ALS|ALS]], [[Huntington’s disease|Huntington’s]] and [[Parkinson’s|Parkinson’s]]<ref>Bredeson, D. (2006). Cell death in the nervous system. Nature, 796-802.</ref>. | ||
<span style="line-height: 1.5em;">Most of the physiological mechanisms whereby neurodegenerative diseases develop and progress share the common feature where [[Proteins aggregate|proteins aggregate]] – that is, the accumulation of misfolded proteins which clump together either intra or extracellularly<ref>Aguzzi, A., &amp;amp;amp;amp;amp;amp; O'Connor, T. (2010). Protein aggregation diseases: pathogenicity and therapeutic perspectives. Nature, 237-248.</ref>. This feature suggests a commonality of the pathological processes of neurodegenerative diseases; this might allow for neuroprotective medicine to be developed to counter protein accumulation<ref>Nieoullon, A. (2011). Neurodegenerative diseases and neuroprotection: current views and prospects. Journal of Applied Biomedicine, 173-183.</ref>.</span> | <span style="line-height: 1.5em;">Most of the physiological mechanisms whereby neurodegenerative diseases develop and progress share the common feature where [[Proteins aggregate|proteins aggregate]] – that is, the accumulation of misfolded proteins which clump together either intra or extracellularly<ref>Aguzzi, A., &amp;amp;amp;amp;amp;amp;amp; O'Connor, T. (2010). Protein aggregation diseases: pathogenicity and therapeutic perspectives. Nature, 237-248.</ref>. This feature suggests a commonality of the pathological processes of neurodegenerative diseases; this might allow for neuroprotective medicine to be developed to counter protein accumulation<ref>Nieoullon, A. (2011). Neurodegenerative diseases and neuroprotection: current views and prospects. Journal of Applied Biomedicine, 173-183.</ref>.</span> | ||
Oxidative stress has been suggested to play an important role in neurodegeneration, that is, the stress associated with the increased production of oxidizing species (such as free radicals) or the decrease in the efficacy of antioxidant defence. Severe oxidative stress can lead to cell death. | Oxidative stress has been suggested to play an important role in neurodegeneration, that is, the stress associated with the increased production of oxidizing species (such as free radicals) or the decrease in the efficacy of antioxidant defence. Severe oxidative stress can lead to cell death.<ref>Lennon SV, Martin SJ, Cotter TG (1991). "Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli". Cell Prolif. 24 (2): 203–14</ref> | ||
=== References === | === References === | ||
<span style="line-height: 1.5em;"><references /></span><br> | <span style="line-height: 1.5em;"><references /></span><br> | ||
Revision as of 13:42, 19 October 2015
Neurodegeneration describes the loss of structure or function to nervous tissue[1]. Neurodegenerative diseases include Alzheimer’s, ALS, Huntington’s and Parkinson’s[2].
Most of the physiological mechanisms whereby neurodegenerative diseases develop and progress share the common feature where proteins aggregate – that is, the accumulation of misfolded proteins which clump together either intra or extracellularly[3]. This feature suggests a commonality of the pathological processes of neurodegenerative diseases; this might allow for neuroprotective medicine to be developed to counter protein accumulation[4].
Oxidative stress has been suggested to play an important role in neurodegeneration, that is, the stress associated with the increased production of oxidizing species (such as free radicals) or the decrease in the efficacy of antioxidant defence. Severe oxidative stress can lead to cell death.[5]
References
- ↑ Merriam-Webster. (n.d.). Medical Dictionary. Available: http://www.merriam-webster.com/medlineplus/neurodegeneration. Last accessed 09/11/2014.
- ↑ Bredeson, D. (2006). Cell death in the nervous system. Nature, 796-802.
- ↑ Aguzzi, A., &amp;amp;amp;amp;amp;amp; O'Connor, T. (2010). Protein aggregation diseases: pathogenicity and therapeutic perspectives. Nature, 237-248.
- ↑ Nieoullon, A. (2011). Neurodegenerative diseases and neuroprotection: current views and prospects. Journal of Applied Biomedicine, 173-183.
- ↑ Lennon SV, Martin SJ, Cotter TG (1991). "Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli". Cell Prolif. 24 (2): 203–14