Innate Immune Response: Difference between revisions
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An innate immune response is a non-specific, quick response produced by the body when it encounters a [[Pathogen|pathogen]]. It is the body's first line of defence. In vertebrates (and invertebrates) it is induced by [[Toll receptors|Toll | An innate immune response is a non-specific, quick response produced by the body when it encounters a [[Pathogen|pathogen]]. It is the body's first line of defence. In vertebrates (and invertebrates) it is induced by [[Toll receptors|Toll]] or Toll-like receptors.<ref>Alan Aderem, Richard J. Ulevitch (17 August 2000) Nature 406, 782-787</ref> The cells involved in the innate immune response are as follows; monocytes which develop into [[Macrophage|macrophages]], [[Neutrophils|neutrophils]], [[Basophils|basophils]] and [[Natural killer cell|natural killer cells]]. Each cell type performs a different function for example macrophages are involved in the [[Phagocytosis|phagocytosis]] of foreign elements within the blood where as basophils release [[Histamine|histamine]] when they encounter [[Allergen|allergens]]. <ref>Merck Sharp, Dohme Corp (2016) Merck and Co., Inc., Kenilworth, NJ, USA http://www.msdmanuals.com/home/immune-disorders/biology-of-the-immune-system/innate-immunity</ref> The cells of the innate immune system initiate the [[Adaptive immune response|adaptive immune response]], which takes 4-7 days to start, therefore innate immunity is crucial at this time to help fight infections. <ref>Janeway CA Jr, Travers P, Walport M, et al (2001) Immunobiology: The Immune System in Health and Disease, 5th edition, New York: Garland Science</ref> | ||
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Latest revision as of 15:29, 21 October 2016
An innate immune response is a non-specific, quick response produced by the body when it encounters a pathogen. It is the body's first line of defence. In vertebrates (and invertebrates) it is induced by Toll or Toll-like receptors.[1] The cells involved in the innate immune response are as follows; monocytes which develop into macrophages, neutrophils, basophils and natural killer cells. Each cell type performs a different function for example macrophages are involved in the phagocytosis of foreign elements within the blood where as basophils release histamine when they encounter allergens. [2] The cells of the innate immune system initiate the adaptive immune response, which takes 4-7 days to start, therefore innate immunity is crucial at this time to help fight infections. [3]
References
- ↑ Alan Aderem, Richard J. Ulevitch (17 August 2000) Nature 406, 782-787
- ↑ Merck Sharp, Dohme Corp (2016) Merck and Co., Inc., Kenilworth, NJ, USA http://www.msdmanuals.com/home/immune-disorders/biology-of-the-immune-system/innate-immunity
- ↑ Janeway CA Jr, Travers P, Walport M, et al (2001) Immunobiology: The Immune System in Health and Disease, 5th edition, New York: Garland Science