Rho independent terminators: Difference between revisions
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Rho- independent termination ( also known as intrinsic termination) is a process carried out in prokaryotic organisms as a mechanism for stopping [[Transcription]]. the mRNA molecule has a sequence of base pairs with a high proportion of [[Cytosine]] and [[Guanine]] bases, these are able to strongly bond to one another with 3 hydrogen bonds forming a RNA duplex in a stable hairpin structure< | Rho- independent termination ( also known as intrinsic termination) is a process carried out in prokaryotic organisms as a mechanism for stopping [[Transcription]]. the mRNA molecule has a sequence of base pairs with a high proportion of [[Cytosine]] and [[Guanine]] bases, these are able to strongly bond to one another with 3 hydrogen bonds forming a RNA duplex in a stable hairpin structure<ref>Lewin, Benjamin (2007). Genes IX. Sudbury, MA: Jones and Bartlett Publishers. ISBN 0-7637-4063-2.</ref><span style="font-size: 11.0667px;">. succeeding the hairpin structure is a chain of [[Uracil]] bases, which only form weak bonds with [[Adenine]]. the transcription of the uracil sequence is coupled with a protein, located on the [[RNA polymerase]], binding to the hairpin structure causing the RNA</span><span style="font-size: 13.28px;"> polymerase to temporarily stop<ref>Wilson KS, von Hippel PH (September 1995). "Transcription termination at intrinsic terminators: the role of the RNA hairpin". Proc. Natl. Acad. Sci. U.S.A. 92 (19): 8793–7</ref>. The temporary lapse and weak uracil- adenine bonds cause the hairpin structure to unwind and dissociate from the RNA</span><span style="font-size: 11.0667px;"> polymerase, thus terminating transcription.</span> | ||
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Revision as of 15:04, 4 December 2016
Rho- independent termination ( also known as intrinsic termination) is a process carried out in prokaryotic organisms as a mechanism for stopping Transcription. the mRNA molecule has a sequence of base pairs with a high proportion of Cytosine and Guanine bases, these are able to strongly bond to one another with 3 hydrogen bonds forming a RNA duplex in a stable hairpin structure[1]. succeeding the hairpin structure is a chain of Uracil bases, which only form weak bonds with Adenine. the transcription of the uracil sequence is coupled with a protein, located on the RNA polymerase, binding to the hairpin structure causing the RNA polymerase to temporarily stop[2]. The temporary lapse and weak uracil- adenine bonds cause the hairpin structure to unwind and dissociate from the RNA polymerase, thus terminating transcription.
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