Conformational change

Definition

Is a change in shape of macromolecule due to the change in external or environmental factors.

Macromolecules are flexible thus it can change its shape in response to different factors.

In biochemistry module, the most common example for conformational change would be G-protein and different type of enzyme.

Typical Factors that could induce conformational change: 

i. temperature

ii. pH value

iii. presence of inhibitor/ligand (especially in enzyme)
iv. mutation 

Example of conformational change (in enzyme)

www.google.com/search

References

https://en.wikipedia.org/wiki/Conformational_change