Receptor tyrosine kinases: Difference between revisions
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Receptor tyrosine kinases are a common type of [[Enzyme-coupled Receptor|Enzyme Coupled receptors]]<ref>Alberts.B, Johnson.A, Lewis.J , Morgan.D , Raff.M ,Roberts.K , Walter.P Molecular Biology of the Cell 6th edition Garland Science</ref>. Receptor tyrosine kinases have a [[cystolic domain|cystolic domain]] with intrinsic [[kinase|kinase]] activity. The binding of [[extracellular ligand|extracellular ligands]] trigger cross [[phosphorylation|phosphorylation]] of the [[tyrosine kinase domain|tyrosine kinase domain]]. Proteins are then able to bind to the phosphorylated tyrosines. Proteins such as [[Grb2|Grb2]] adaptor protein (involved in the [[Ras pathway|Ras pathway]]) which has the ability to bind to one of the phosphate groups on specific tyrosine residues. This, consequentially, recruits a [[Guanine nucleotide exchange factor|Guanine nucleotide exchange factor]] that activate monomeric [[GTPase|GTPases]] by stimulating release of [[GDP|GDP]] to allow binding of [[GTPase|GTP]]. | |||
=== References === | |||
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Latest revision as of 19:56, 4 December 2016
Receptor tyrosine kinases are a common type of Enzyme Coupled receptors[1]. Receptor tyrosine kinases have a cystolic domain with intrinsic kinase activity. The binding of extracellular ligands trigger cross phosphorylation of the tyrosine kinase domain. Proteins are then able to bind to the phosphorylated tyrosines. Proteins such as Grb2 adaptor protein (involved in the Ras pathway) which has the ability to bind to one of the phosphate groups on specific tyrosine residues. This, consequentially, recruits a Guanine nucleotide exchange factor that activate monomeric GTPases by stimulating release of GDP to allow binding of GTP.
References
- ↑ Alberts.B, Johnson.A, Lewis.J , Morgan.D , Raff.M ,Roberts.K , Walter.P Molecular Biology of the Cell 6th edition Garland Science