CORN law: Difference between revisions
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The CORN law is the rule that allows to distinquish [ | The CORN law is the rule that allows to distinquish [[enantiomers|enantiomers]] from each other. In other words, it determines whether the [[amino acids|amino acid]] is a [[L-isomers|L-isomer]] or [[D-isomer|D-isomer]]. All amino acids have the same core and differ due to their side chain. There are four different groups attached to [[α-carbon|α-carbon]], making α-amino acids [[chiral|chiral]]. These groups are: [[carboxylic acid group|carboxylic acid group]] (-COO<sup>-</sup>), [[amino group|amino group]] (-NH<sub>2</sub>), a [[hydrogen|hydrogen]] [[atoms|atom]] and a distinctive R group (representation of side chain).<br> | ||
The '''CORN''' is an acronym for -'''CO'''OH , the -'''R''' and -'''N'''H<sub>2</sub> groups. If the carboxyl group is followed by the R group and the amino group in clockwise direction, then the amino acid is a L-isomer. If the movement is in the anticlockwise direction, the amino acid is a D-isomer< | The '''CORN''' is an acronym for -'''CO'''OH , the -'''R''' and -'''N'''H<sub>2</sub> groups. If the carboxyl group is followed by the R group and the amino group in clockwise direction, then the amino acid is a L-isomer. If the movement is in the anticlockwise direction, the amino acid is a D-isomer<ref>Jeremy M. Berg, John L. Tymoczko, Lubert Stryer. Biochemsitry. 7th. ed. New York: WH Freeman and Company. 2011.</ref>. | ||
=== References === | |||
<references /><br> | |||
Revision as of 21:28, 6 December 2016
The CORN law is the rule that allows to distinquish enantiomers from each other. In other words, it determines whether the amino acid is a L-isomer or D-isomer. All amino acids have the same core and differ due to their side chain. There are four different groups attached to α-carbon, making α-amino acids chiral. These groups are: carboxylic acid group (-COO-), amino group (-NH2), a hydrogen atom and a distinctive R group (representation of side chain).
The CORN is an acronym for -COOH , the -R and -NH2 groups. If the carboxyl group is followed by the R group and the amino group in clockwise direction, then the amino acid is a L-isomer. If the movement is in the anticlockwise direction, the amino acid is a D-isomer[1].
References
- ↑ Jeremy M. Berg, John L. Tymoczko, Lubert Stryer. Biochemsitry. 7th. ed. New York: WH Freeman and Company. 2011.