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Immunoglobulin D (IgD) is an [[Antibody|antibody]] class which in the humoral, specific arm of Immunity. It's main function is as an antigen receptor on [[B | Immunoglobulin D (IgD) is an [[Antibody|antibody]] class which in the humoral, specific arm of Immunity. It's main function is as an [[Antigen receptor|antigen receptor]] on [[B cells|B lymphocytes]]. Because of this, it has very low serum concentrations. IgD and [[IgM|IgM]] are the only 2 Immunoglobins that are co-expressed. | ||
It is roughly 185 kDa in molecular weight and has 4 domains; 2 δ heavy chains and 2 light chains. | It is roughly 185 kDa in molecular weight and has 4 domains; 2 δ heavy chains and 2 light chains. | ||
B lymphocytes that co-express IgD and IgM have not undergone class switching. As a result, a long [[MRNA|mRNA]] transcript is produced which, when [[Splicing|spliced]] can produce either of the mRNA molecules responsible for producing IgD or IgM depending where the cuts are made<ref>Murphy, K. Weaver, C. (2016) Janeway's Immunobiology. 8th Edition. New York: Garland Sciences. Chapter 5, Page 195</ref>. | |||
=== References === | |||
<references /> | |||
Latest revision as of 07:46, 28 October 2017
Immunoglobulin D (IgD) is an antibody class which in the humoral, specific arm of Immunity. It's main function is as an antigen receptor on B lymphocytes. Because of this, it has very low serum concentrations. IgD and IgM are the only 2 Immunoglobins that are co-expressed.
It is roughly 185 kDa in molecular weight and has 4 domains; 2 δ heavy chains and 2 light chains.
B lymphocytes that co-express IgD and IgM have not undergone class switching. As a result, a long mRNA transcript is produced which, when spliced can produce either of the mRNA molecules responsible for producing IgD or IgM depending where the cuts are made[1].
References
- ↑ Murphy, K. Weaver, C. (2016) Janeway's Immunobiology. 8th Edition. New York: Garland Sciences. Chapter 5, Page 195