GTPase: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
== Overview == | == Overview == | ||
GTPases are a group of [[Enzyme|enzymes]] which hydrolyse [[GTP|GTP]] to [[GDP|GDP]] (a [[Phosphate|phosphate]] group is removed). They play an important roll in [[Cell signalling|cell signalling]] pathways for example, GTP/GDP bound [[G-proteins|G proteins have intrinsic ]][[GTPase|GTPase]] activity to slowly reset themselves to their resting state state once it has fullfilled its function <ref>Berg J, Tymoczko J and Stryer L, 2007. Biochemistry, 6th Edition, New York: W.H.Freeman &amp;amp;amp;amp;amp;amp;amp;amp; Co Ltd. (page 387)</ref> (Please note not all G proteins have an active intrinsic GTPase activity and require association with GAP ( | GTPases are a group of [[Enzyme|enzymes]] which hydrolyse [[GTP|GTP]] to [[GDP|GDP]] (a [[Phosphate|phosphate]] group is removed). They play an important roll in [[Cell signalling|cell signalling]] pathways for example, GTP/GDP bound [[G-proteins|G proteins have intrinsic ]][[GTPase|GTPase]] activity to slowly reset themselves to their resting state state once it has fullfilled its function <ref>Berg J, Tymoczko J and Stryer L, 2007. Biochemistry, 6th Edition, New York: W.H.Freeman &amp;amp;amp;amp;amp;amp;amp;amp;amp; Co Ltd. (page 387)</ref> (Please note not all G proteins have an active intrinsic GTPase activity and require association with [[GAP (GTPase-activating proteins)|GAP]] in order to hydrolyse GTP. They are also involved in the synthesis of [[Proteins|proteins]] at the [[Ribosomes|ribosome]] <ref>Berg J, Tymoczko J and Stryer L, 2007. Biochemistry, 6th Edition, New York: W.H.Freeman &amp;amp;amp;amp;amp;amp;amp;amp; Co Ltd. (page 881)</ref>. They also have roles in [[Vesicle|vesicle]] movement and [[Cell division|cell division]].<br> | ||
The [[ | The [[G protein alpha subunit|alpha subunit of]] the heterotrimeric G-protein is a GTPase. <ref>Hardin J., Bertoni G., Kleinsmith L., 2011 Beckers World Of The Cell. 8th Edition, San Fransisco: Pearson Education</ref> | ||
=== References === | === References === | ||
<references /> | <references /> | ||
Revision as of 19:39, 2 December 2017
Overview
GTPases are a group of enzymes which hydrolyse GTP to GDP (a phosphate group is removed). They play an important roll in cell signalling pathways for example, GTP/GDP bound G proteins have intrinsic GTPase activity to slowly reset themselves to their resting state state once it has fullfilled its function [1] (Please note not all G proteins have an active intrinsic GTPase activity and require association with GAP in order to hydrolyse GTP. They are also involved in the synthesis of proteins at the ribosome [2]. They also have roles in vesicle movement and cell division.
The alpha subunit of the heterotrimeric G-protein is a GTPase. [3]
References
- ↑ Berg J, Tymoczko J and Stryer L, 2007. Biochemistry, 6th Edition, New York: W.H.Freeman &amp;amp;amp;amp;amp;amp;amp;amp; Co Ltd. (page 387)
- ↑ Berg J, Tymoczko J and Stryer L, 2007. Biochemistry, 6th Edition, New York: W.H.Freeman &amp;amp;amp;amp;amp;amp;amp; Co Ltd. (page 881)
- ↑ Hardin J., Bertoni G., Kleinsmith L., 2011 Beckers World Of The Cell. 8th Edition, San Fransisco: Pearson Education