GRB2: Difference between revisions
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Growth factor receptor-bound protein 2. Found in humans, it is an adapter protein that provides a critical link between cell surface growth factor receptors and the Ras | Growth factor receptor-bound protein 2. Found in [[humans|humans]], it is an [[adapter protein|adapter protein]] that provides a critical link between [[cell|cell]] surface [[growth factor receptors|growth factor receptors]] and the [[Ras signalling pathway|Ras signalling pathway]]. | ||
Isoform 2 acts as dominant negative protein over GRB2 and by | Isoform 2 acts as [[dominant negative protein|dominant negative protein]] over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. It does so by inhibiting EGF-induced transactivation of a RAS-responsive element<ref>This is a reference to a website about GRB2. http://www.uniprot.org/uniprot/P62993</ref>. | ||
=== References | === References === | ||
<references /> | <references /> | ||
Latest revision as of 17:38, 4 December 2017
Growth factor receptor-bound protein 2. Found in humans, it is an adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signalling pathway.
Isoform 2 acts as dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. It does so by inhibiting EGF-induced transactivation of a RAS-responsive element[1].
References
- ↑ This is a reference to a website about GRB2. http://www.uniprot.org/uniprot/P62993