CORN law: Difference between revisions

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The CORN law is the rule that allows to distinquish [https://teaching.ncl.ac.uk/bms/wiki/index.php/Enantiomer enantiomers] from each other. In other word, it determines whether the [https://teaching.ncl.ac.uk/bms/wiki/index.php/Amino_acids amino acid] is a [https://teaching.ncl.ac.uk/bms/wiki/index.php/Optical_isomers L-isomer or D-isomer]. All amino acids have the same core and differ due to their side chain. There are four different group attached to&nbsp;[https://teaching.ncl.ac.uk/bms/wiki/index.php/Alpha_carbon α-carbon], making α-amino acids [https://teaching.ncl.ac.uk/bms/wiki/index.php/Chiral_centre chiral]. These groups are: [https://teaching.ncl.ac.uk/bms/wiki/index.php/Carboxyl_group carboxylic acid group ](-COO<sup>-</sup>), [https://teaching.ncl.ac.uk/bms/wiki/index.php/Amino_group amino group] (-NH<sub>2</sub>), a [https://teaching.ncl.ac.uk/bms/wiki/index.php/Hydrogen hydrogen] atom and a distinctive R group (representation of side chain).<br>
The CORN law is the rule that allows to distinquish [[Enantiomers|enantiomers]] from each other. In other words, it determines whether the [[Amino acids|amino acid]] is a [[L-isomer|L-isomer]] or [[D-isomer|D-isomer]]. All amino acids have the same core and differ due to their side chain. There are four different groups attached to [[Α-carbon|α-carbon]], making α-amino acids [[Chiral|chiral]]. These groups are: [[Carboxylic acid group|carboxylic acid group]] (-COO<sup>-</sup>), [[Amino group|amino group]] (-NH<sub>2</sub>), a [[Hydrogen|hydrogen]] [[atom|atom]] and a distinctive R group (representation of side chain).  


The '''CORN'''&nbsp;is an acronym for -'''CO'''OH , the -'''R''' &nbsp;and -'''N'''H<sub>2</sub> groups. If the carboxyl group is followed by the R group and the amino group in clockwise direction, then the amino acid is a L-isomer. If the movement is in the anticlockwise direction, the amino acid is a D-isomer<sup>[1]</sup>.  
The '''CORN''' is an acronym for -'''CO'''OH , the -'''R''' and -'''N'''H<sub>2</sub> groups. If the carboxyl group is followed by the R group and the amino group in a clockwise direction, then the amino acid is an L-isomer. If the movement is in the anticlockwise direction, the amino acid is a D-isomer<ref>Jeremy M. Berg, John L. Tymoczko, Lubert Stryer. Biochemistry. 7th. ed. New York: WH Freeman and Company. 2011.</ref>.  


<br>
=== References ===


'''References:'''
<references />
 
1.Jeremy M. Berg, John L. Tymoczko, Lubert Stryer. Biochemsitry. 7th. ed. New York: WH Freeman and Company. 2011.

Latest revision as of 19:57, 4 December 2017

The CORN law is the rule that allows to distinquish enantiomers from each other. In other words, it determines whether the amino acid is a L-isomer or D-isomer. All amino acids have the same core and differ due to their side chain. There are four different groups attached to α-carbon, making α-amino acids chiral. These groups are: carboxylic acid group (-COO-), amino group (-NH2), a hydrogen atom and a distinctive R group (representation of side chain).

The CORN is an acronym for -COOH , the -R and -NH2 groups. If the carboxyl group is followed by the R group and the amino group in a clockwise direction, then the amino acid is an L-isomer. If the movement is in the anticlockwise direction, the amino acid is a D-isomer[1].

References

  1. ↑ Jeremy M. Berg, John L. Tymoczko, Lubert Stryer. Biochemistry. 7th. ed. New York: WH Freeman and Company. 2011.
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