Formylmethionyl Transfer RNA: Difference between revisions
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Created page with 'Formylmethionyl Transfer RNA<ref>Berg J.M., Tymoczko J.L., and Stryer L.(2008). Biochemistry. Sixth Edition. New York: W.H. Freeman and Company p. 871</ref> (often abbreviated si…' |
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Formylmethionyl Transfer RNA<ref>Berg J.M., Tymoczko J.L., and Stryer L.(2008). Biochemistry. Sixth Edition. New York: W.H. Freeman and Company p. 871</ref> (often abbreviated simply to fMet- | Formylmethionyl Transfer RNA<ref name="Reference">Berg J.M., Tymoczko J.L., and Stryer L.(2008). Biochemistry. Sixth Edition. New York: W.H. Freeman and Company p. 871</ref> (often abbreviated simply to fMet-tRNA<sup>fmet</sup> ) is an aminoacyl-tRNA which is used in the initiation of ''[[Escherichia coli|Escherichia coli]]'' [[Protein|protein]] synthesis. The [[N-terminal|N-Terminal]] of the beginning of the protein is usually a [[Methionine|Methionine]] (Met, M), but in the case of ''[[Escherichia coli|E. coli]]'', a formyl group can be introduced in this [[Residue|residue]] to give N-formylmethionine also known as fMet. | ||
Initiation of [[ | Initiation of [[Bacteria|bacterial]] [[Translation|translation]] requires formylmethionyl transfer RNA which binds to the start [[Codon|codon]] [[AUG|AUG]] of the newly synthesised [[MRNA|mRNA]] only after the [[30S|30S]] subunit is itself attached to the [[MRNA|mRNA]]. | ||
Formylmethionyl Transfer RNA can be distinguished from [[TRNA|tRNA]] that recognise other [[Prokaryotes|prokaryotic]] start codons (such as GUG or UUG) as much as they recognise AUG. | Formylmethionyl Transfer RNA can be distinguished from [[TRNA|tRNA]] that recognise other [[Prokaryotes|prokaryotic]] start codons (such as GUG or UUG) as much as they recognise AUG. | ||
=== Reference === | |||
<references / | <references /> | ||
Latest revision as of 20:17, 4 December 2017
Formylmethionyl Transfer RNA[1] (often abbreviated simply to fMet-tRNAfmet ) is an aminoacyl-tRNA which is used in the initiation of Escherichia coli protein synthesis. The N-Terminal of the beginning of the protein is usually a Methionine (Met, M), but in the case of E. coli, a formyl group can be introduced in this residue to give N-formylmethionine also known as fMet.
Initiation of bacterial translation requires formylmethionyl transfer RNA which binds to the start codon AUG of the newly synthesised mRNA only after the 30S subunit is itself attached to the mRNA.
Formylmethionyl Transfer RNA can be distinguished from tRNA that recognise other prokaryotic start codons (such as GUG or UUG) as much as they recognise AUG.
Reference
- ↑ Berg J.M., Tymoczko J.L., and Stryer L.(2008). Biochemistry. Sixth Edition. New York: W.H. Freeman and Company p. 871